Punica granatum (Grinad) : medicinal properties in alcoholic extraction

Punica granatum (Grinad, grenade) — family Punicacées.

Scientific synonyms : Punica florida-Salisb, P nana-L, P spinosa-Lam.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 43 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 220 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of hepatocellular carcinoma, leukaemia, breast cancer, colorectal cancer, squamous cell carcinoma of the mouth, prostate cancer and urothelial bladder cancer

   Plant part used: Fruit pericarp.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tag HM (2019)

     Excerpt Punica granatum (POM) & Silybum marianum (MT) receiving attention as potential potent anti-oxidant & anti-mutant agents. In this context, the present study was designed to highlight their effects either in vitro as well as in vivo model of induced Hepatocellular carcinoma (HCC).

   • According to ZHOU T (2024)

     Excerpt Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with an insidious onset and poor prognosis. Pomegranate is a fruit rich in many natural products with anti-cancer potential; however, its direct biological effects are difficult to evaluate in vitro because of changes in its active components after absorption & metabolism.

   • According to FAHMY HA (n.d.)

     Excerpt Furthermore, PP demonstrated anticancer effects against different cancer types, for example, colon, liver, thyroid, uterine, breast, bladder, prostate, leukemia, & osteosarcoma. Moreover, it displayed anti-osteoporosis, anti-hyperglycemic, antidiabetic, antihypertensive, vasculoprotective, hepatoprotective, neuroprotective, & immunomodulatory effects.

   • According to Wong TL (2021)

     Excerpt It discusses the chemical constituents of pomegranate, the results of both preclinical (in vitro, ex vivo & in vivo) & clinical studies on the anticancer effect of pomegranate phytochemicals & molecular targets in numerous types of cancers, such as breast, gastrointestinal tract (oral, colon, liver & pancreas), gynecological (uterine & ovarian), hematological (lymphoma, leukemia & myeloma), lung, neurological (glioma), urogenital (bladder & prostate), bioavailability, pharmacokinetics & safety of pomegranate constituents. Research on pomegranate (Punica granatum L.), a fruit of the Punicaceae family, has shown enormous potential for cancer prevention & intervention.

   • According to Lavaee F (2019)

     Excerpt Conclusion: As the findings indicated, the methanolic & ethanolic extracts of the bark & root of P granatum had anti-Candida activities. granatum with those of two routine antifungal agents (i.e., Fluconazole & nystatin) on oral Candida strains isolated from liver transplant recipients.

2. 2

   Diabetic neuropathy

   Plant part used: Fruit pericarp.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to RAAFAT K (n.d.)

     Excerpt To evaluate the effect of Punica granatum (Pg) rind extract & its spray dried biopolymeric dispersions with casein (F1) or chitosan (F2) against Diabetes mellitus (DM) & diabetic neuropathy (DN). Conclusion: Pg extract, F1, F2, & GA could be considered as a new therapeutic potential for the amelioration of diabetic neuropathic pain & the observed in vivo antioxidant potential may be involved in its antinociceptive effect.

   • According to Laurindo LF (2024)

     Excerpt Pomegranate (Punica granatum L.) is a multipurpose dietary & medicinal plant known for its ability to promote various health benefits. The peel, juice, roots, bark, seeds, flowers, & leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, a effects.

   • According to Das S (2012)

     Excerpt Punica granatum is used in Indian Unani medicine for treatment of diabetes mellitus. granatum in alloxan-induced diabetic rats.

   • According to RAMADAM S (2021)

     Excerpt The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, & Punica granatum leaves had any effect on blood sugar levels in normal & streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. granatum methanolic extracts, & diabetics treated with insulin.

   • According to BARGHCHI H (2023)

     Excerpt Methods: In phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw & even adjusted models.

3. 3

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Das S (2012)

     Excerpt Punica granatum is used in Indian Unani medicine for treatment of diabetes mellitus. granatum in alloxan-induced diabetic rats.

   • According to RAAFAT K (n.d.)

     Excerpt To evaluate the effect of Punica granatum (Pg) rind extract & its spray dried biopolymeric dispersions with casein (F1) or chitosan (F2) against Diabetes mellitus (DM) & diabetic neuropathy (DN). Conclusion: Pg extract, F1, F2, & GA could be considered as a new therapeutic potential for the amelioration of diabetic neuropathic pain & the observed in vivo antioxidant potential may be involved in its antinociceptive effect.

   • According to RAMADAM S (2021)

     Excerpt The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, & Punica granatum leaves had any effect on blood sugar levels in normal & streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. granatum methanolic extracts, & diabetics treated with insulin.

   • According to BARGHCHI H (2023)

     Excerpt Methods: In phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw & even adjusted models.

   • According to Laurindo LF (2024)

     Excerpt Pomegranate (Punica granatum L.) is a multipurpose dietary & medicinal plant known for its ability to promote various health benefits. The peel, juice, roots, bark, seeds, flowers, & leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, a effects.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.