Punica granatum (Grinad) : vertus médicinales en extraction alcoolique

Punica granatum (Grinad, grenade) — famille Punicacées.

Synonymes scientifiques : Punica florida-Salisb, P nana-L, P spinosa-Lam.

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 43 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 220 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique, leucémique, mammaire, colorectal, oral squameux, prostatique & urothélial vésical

   Partie usitée : Péricarpe de Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Tag HM (2019)

     Extrait Punica granatum (POM) & Silybum marianum (MT) receiving attention as potential potent anti-oxidant & anti-mutant agents. In this context, the present study was designed to highlight their effects either in vitro as well as in vivo model of induced Hepatocellular carcinoma (HCC).

   • Selon ZHOU T (2024)

     Extrait Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with an insidious onset and poor prognosis. Pomegranate is a fruit rich in many natural products with anti-cancer potential; however, its direct biological effects are difficult to evaluate in vitro because of changes in its active components after absorption & metabolism.

   • Selon FAHMY HA (s.d.)

     Extrait Furthermore, PP demonstrated anticancer effects against different cancer types, for example, colon, liver, thyroid, uterine, breast, bladder, prostate, leukemia, & osteosarcoma. Moreover, it displayed anti-osteoporosis, anti-hyperglycemic, antidiabetic, antihypertensive, vasculoprotective, hepatoprotective, neuroprotective, & immunomodulatory effects.

   • Selon Wong TL (2021)

     Extrait It discusses the chemical constituents of pomegranate, the results of both preclinical (in vitro, ex vivo & in vivo) & clinical studies on the anticancer effect of pomegranate phytochemicals & molecular targets in numerous types of cancers, such as breast, gastrointestinal tract (oral, colon, liver & pancreas), gynecological (uterine & ovarian), hematological (lymphoma, leukemia & myeloma), lung, neurological (glioma), urogenital (bladder & prostate), bioavailability, pharmacokinetics & safety of pomegranate constituents. Research on pomegranate (Punica granatum L.), a fruit of the Punicaceae family, has shown enormous potential for cancer prevention & intervention.

   • Selon Lavaee F (2019)

     Extrait Conclusion: As the findings indicated, the methanolic & ethanolic extracts of the bark & root of P granatum had anti-Candida activities. granatum with those of two routine antifungal agents (i.e., Fluconazole & nystatin) on oral Candida strains isolated from liver transplant recipients.

2. 2

   Neuropathie diabétique

   Partie usitée : Péricarpe de Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon RAAFAT K (s.d.)

     Extrait To evaluate the effect of Punica granatum (Pg) rind extract & its spray dried biopolymeric dispersions with casein (F1) or chitosan (F2) against Diabetes mellitus (DM) & diabetic neuropathy (DN). Conclusion: Pg extract, F1, F2, & GA could be considered as a new therapeutic potential for the amelioration of diabetic neuropathic pain & the observed in vivo antioxidant potential may be involved in its antinociceptive effect.

   • Selon Laurindo LF (2024)

     Extrait Pomegranate (Punica granatum L.) is a multipurpose dietary & medicinal plant known for its ability to promote various health benefits. The peel, juice, roots, bark, seeds, flowers, & leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, a effects.

   • Selon Das S (2012)

     Extrait Punica granatum is used in Indian Unani medicine for treatment of diabetes mellitus. granatum in alloxan-induced diabetic rats.

   • Selon RAMADAM S (2021)

     Extrait The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, & Punica granatum leaves had any effect on blood sugar levels in normal & streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. granatum methanolic extracts, & diabetics treated with insulin.

   • Selon BARGHCHI H (2023)

     Extrait Methods: In phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw & even adjusted models.

3. 3

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Das S (2012)

     Extrait Punica granatum is used in Indian Unani medicine for treatment of diabetes mellitus. granatum in alloxan-induced diabetic rats.

   • Selon RAAFAT K (s.d.)

     Extrait To evaluate the effect of Punica granatum (Pg) rind extract & its spray dried biopolymeric dispersions with casein (F1) or chitosan (F2) against Diabetes mellitus (DM) & diabetic neuropathy (DN). Conclusion: Pg extract, F1, F2, & GA could be considered as a new therapeutic potential for the amelioration of diabetic neuropathic pain & the observed in vivo antioxidant potential may be involved in its antinociceptive effect.

   • Selon RAMADAM S (2021)

     Extrait The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, & Punica granatum leaves had any effect on blood sugar levels in normal & streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. granatum methanolic extracts, & diabetics treated with insulin.

   • Selon BARGHCHI H (2023)

     Extrait Methods: In phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw & even adjusted models.

   • Selon Laurindo LF (2024)

     Extrait Pomegranate (Punica granatum L.) is a multipurpose dietary & medicinal plant known for its ability to promote various health benefits. The peel, juice, roots, bark, seeds, flowers, & leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, a effects.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.