Quassia amara (Kina) : medicinal properties in alcoholic extraction

Quassia amara (Kina, Kininn’Kayenn’, Quina, Cayenne quinine, Quinine-de-Cayenne) — family Rubiacées.

Scientific synonyms : Quassia officinalis Rich..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 66 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to TOMA W (2003)

     Excerpt We evaluated the possible antiedematogenic, antinociceptive and/or sedative effects of four different extracts obtained from the bark of Quassia amara namely, 70% ethanol (70EtOH), 100% ethanol (100 EtOH), dichloromethane (DCM) & hexane extracts (HEX). However, when administered intraperitoneally, the HEX extract decreased the paw edema induced by carrageenan, showed antinociceptive effects on the hot-plate test & on acetic acid-induced writhing, & showed sedative effects on pentobarbital-induced sleep.

   • According to Balakrishna A (2022)

     Excerpt Various studies indicate that QA possess different biological properties namely anti-diabetic, anti-inflammatory, anti-hyperglycemic, anti-leishmanial, anti-malarial, anti-nociceptive, anti-ulcer, anti-fertility & sedative. Quassia amara Linn., is a shrub & world widely known as 'bitter-wood' belongs to Simaroubaceae family.

   • According to Kunnathodi F (2015)

     Excerpt Quassin is the major secondary chemical compound in it, which is under investigation as an anti-malarial compound.

   • According to Reya E (2017)

     Excerpt Quassia amara Linn., famous as bitterwood or quassia, is a neotropical forest shrub indigenous to Northern Brazil. Indian Quassia, mostly seen in northern & eastern states, is a source of numerous compounds including b – carbonile, cantin-6 alkaloids & primarily, the bitter compounds known as quassinoids.

   • According to Raji Y (n.d.)

     Excerpt The effect of Quassia amara extract & two isolated compounds from the extract, quassin & 2- methoxycathine-6-one on haematological parameters was studied in rats. The results suggest that quassia extract possesses Antianaemic property.

2. 2

   Fungal infection: C. albicans, C. parapsilosis, C. glabrata, C. krusei, Malassezia furfur

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Diehl C (2016)

     Excerpt Contrarily, QWE had no effect on the growth of Chlamydia trachomatis, but uniquely altered the morphology & quantity of chlamydial inclusions.To the best of our knowledge, this is the first time that QWE is shown to have antiparasitic activity on Trichomonas vaginalis & Demodex spp, an antifungal activity on Malassezia furfur & Candida spp & an antibacterial activity on P. krusei, the latest at a lesser extent, & Malassezia furfur isolated from samples of infected patients, inhibiting the growth of fungi in both a time- & dose-dependent manner.The antibacterial activity of QWE was demonstrated in cultures of P.

   • According to AJAIYEOBA EO (2003)

     Excerpt AJAIYEOBA EO et al, Antibacterial & antifungal activities of Quassia undulata & Quassia amara extracts in vitro.

   • According to Obembe OO (2020)

     Excerpt Quassia amara stem bark has been reputed to have strong antimalarial, antimicrobial, antiulcerative & amoebicidal properties.

   • According to CACHET N. (2009)

     Excerpt With respect to Plasmodium falciparum erythrocytic stages, SkD was almost inactive on earlier & later parasite stages, but potently active at the 30th h of parasite cycle when DNA replicates in mature trophozoites.

3. 3

   Bacterial infection: P. acnes and coagulase-positive staphylococci

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to AJAIYEOBA EO (2003)

     Excerpt AJAIYEOBA EO et al, Antibacterial & antifungal activities of Quassia undulata & Quassia amara extracts in vitro.

   • According to Diehl C (2016)

     Excerpt acnes & coagulase- positive Staphylococci where the growth of the bacteria was reduced in a significant manner (p<0.05) & at a lesser extent in cultures of coagulase-negative Staphylococci where the growth inhibition was not statistically significant. Quassia amara is a plant of the family Simaroubaceae of Northern Brazilian origin.Its use in folk medicine is widespread, especially as an antiparasitic, antifungal & antibacterialagent.

   • According to Obembe OO (2020)

     Excerpt Quassia amara stem bark has been reputed to have strong antimalarial, antimicrobial, antiulcerative & amoebicidal properties.

   • According to Evans DA (1991)

     Excerpt Crushed aqueous extracts of leaf, wood, bark & flowers of Quassia amara showed antilarval activity against C quinquefasciatus. This compound is an unsaturated lactone & it gave a positive response to the Legal test, characteristic of unsaturated lactones.

   • According to CACHET N. (2009)

     Excerpt With respect to Plasmodium falciparum erythrocytic stages, SkD was almost inactive on earlier & later parasite stages, but potently active at the 30th h of parasite cycle when DNA replicates in mature trophozoites.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.