Rhodiola rosea (Rhodiola) : medicinal properties in alcoholic extraction

Rhodiola rosea (Rhodiola, Golden root, Racine dorée) — family Crassulacées.

Scientific synonyms : Rhodiola roanensis (Britton) Britton, Sedum Rhodiola DC., S. roanense Britton, S. rosea (L.) Scop., S. rosea var. roanense (Britton) A. Berger.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 203 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for Lewis carcinoma

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to BERNATIONENE J (2023)

     Excerpt The roots & rhizomes of Rhodiola rosea L. Recent studies indicate that RR may be used to treat diabetes, cancer, & a variety of cardiovascular & neurological disorders such as Alzheimer's & Parkinson's diseases.

   • According to ZHANG Y (2019)

     Excerpt To explore the anti-tumor immune function of the Tibetan medicine Rhodiola rosea L. Methods: Lewis’s lung cancer-bearing mice were randomly divided into normal saline group, 500 mg/kg RRL ethanol extract treatment group, & 10 mg/kg cyclophosphamide (CTX) treatment group.

   • According to ZHANG X (2020)

     Excerpt Methods: The effects of RR on NSCLC were examined in Lewis lung carcinoma (LLC) tumor-bearing mice models. (RR), a well-known traditional Chinese medicine (TCM), has been turned out to be effective in anti-lung cancer therapy, but its molecular mechanism of action has not been clearly understood.

   • According to Li Y (2017)

     Excerpt Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to non-specifically enhance the natural resistance of the body to both physical & behavior stresses for fighting fatigue and depression. Recent findings: In addition to its multiplex stress-protective activity, RR extracts have recently demonstrated its anti-aging, anti-inflammation, Immunostimulating, DNA repair & anti-cancer effects in different model systems.

   • According to WANG S (2023)

     Excerpt Pharmacological studies have demonstrated that Rosavin has a variety of biological activities, including antioxidant, lipid-lowering, analgesic, antiradiation, antitumor & immunomodulation effects.

2. 2

   Neuroinflammation

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gan Z (2024)

     Excerpt This study undertakes a systematic review of both domestic & international literature, assessing the research advancements a chemical functional value of polysaccharides derived from Rhodiola rosea. This genus contains key compounds such as ginsenosides, polysaccharides, & flavonoids, which possess anti-inflammatory, antioxidant, hypoglycaemic, immune-enhancing, & anti-hypoxic properties.

   • According to Pooja Bawa A.S (2009)

     Excerpt Inhibition of nystatin induced oedema & phospholipase A2 suggested that membrane stabilization could be the most probable mechanism of action of RTE in anti-inflammation. The anti-inflammatory activity was determined through carrageenan-induced paw oedema, formaldehyde-induced arthritis nystatin-induced paw oedema in rat model.

   • According to NABAVI SF (2016)

     Excerpt The roots of RR possess a wide range of pharmacological activities such as antioxidant, anti-inflammatory, anticancer, cardioprotective, & neuroprotective effects that are because of the presence of different phytochemicals such as phenols & flavonoids. A plethora of studies report that RR has potent neuroprotective effects through the suppression of oxidative stress, neuro-inflammation, & excitotoxicity in brain tissues & antagonism of oncogenic p21-activated kinase.

   • According to Li Y (2017)

     Excerpt Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to non-specifically enhance the natural resistance of the body to both physical & behavior stresses for fighting fatigue and depression. Recent findings: In addition to its multiplex stress-protective activity, RR extracts have recently demonstrated its anti-aging, anti-inflammation, Immunostimulating, DNA repair & anti-cancer effects in different model systems.

   • According to LI Y (2021)

     Excerpt The possible mechanisms of RRC are largely through antioxidant, anti-apoptosis activities, anti-inflammatory, repressing lipid peroxidation, antigliosis, & alleviating the pathological blood Brain barrier damage. Pooled preclinical data showed that compared with the controls, RRC could improve NFS (Zea Longa (p < 0.01), modified neurological severity score (mNSS) (p < 0.01), rotarod tests (p < 0.01), IV (p < 0.01), as well as brain edema (p < 0.01).

3. 3

   Bacterial infection: Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Pseudomonas aeruginosa

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahmed M (2015)

     Excerpt Rhodiola rosea, a medicinal plant with demonstrated adaptogenic properties, has recently been reported to contain active compounds with antimicrobial activity. Serum from both groups collected 15 min post-marathon significantly promoted the growth of Escherichia coli in culture as compared to serum collected the day before the marathon (P = 0.003, all subjects).

   • According to Author (2018)

     Excerpt The chemical profiles were determined by High-performance Liquid Chromatography with a diode-array detector (HPLC-DAD) & Gas chromatography-mass spectrometry (GC-MS), antioxidant activity by (1,1-Diphenyl-2-picrylhydrazyl) Scavenging Capacity Assay (DPPH), (2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) Scavenging Capacity Assay (ABTS) & Ferric Reducing Antioxidant Power Assay (FRAP) & antimicrobial properties were expressed as minimum inhibitory concentration (MIC) & minimum bacterial concentration (MBC) values following the broth microdilutions method. Roseroot (Rhodiola rosea L.) belongs to plants revealing adaptogenic properties, which are attributed to the presence of specific phenolic compounds & are reflected mainly as antioxidant activity.

   • According to Zdanowska (2009)

     Excerpt Zdanowska et al, the effect of Rhodiola rosea extracts on the bacterial infection in mice.

   • According to CUI Q (2018)

     Excerpt The time-of-addition experiments suggest that, mechanistically, the RR extract & the effective compounds act at an early step in the infection cycle following initial cell attachment, but prior to viral/cell membrane fusion. Traditional Chinese medicines (TCMs) represent a huge reservoir of bioactive chemicals & many TCMs have been shown to have antiviral activities.

   • According to Wang, H (2009)

     Excerpt The aim of this study was to investigate the antiviral effects of salidroside, a major component of Rhodiola rosea L. In conclusion, salidroside possesses antiviral activities against CVB3 and it may represent a potential therapeutic agent for viral myocarditis.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.