Ricinus communis (Fèy-grenn’) : medicinal properties in alcoholic extraction

Ricinus communis (Fèy-grenn’, PalmaKristi, Karapat, Risen, Seed-leaf, Palma-Christi, Carapate, Castor oil plant, Feuille-à-graine, Ricin) — family Euphorbiacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 42 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shokeen P (2008)

     Excerpt We investigated the antidiabetic activity of 50% ethanolic extract of roots of Ricinus communis (RCRE) along with its Bioassay-guided purification. communis seems to have a promising value for the development of a potent Phytomedicine for diabetes.

   • According to Gad-Elkareem M (2019)

     Excerpt This study aimed to investigate the antidiabetic effect of ethanolic & aqueous-ethanolic extracts of wild Ricinus communis leaves in streptozotocin (STZ) induced diabetic rats. Diabetic rats were administered orally with the mentioned extracts at doses of 300 & 600 mg/kg/BW for 14 days & the obtained results of different biochemical parameters were compared with normal control, diabetic control & standard drug Glibenclamide (5 mg/kg/BW).

   • According to Hassan HN (2019)

     Excerpt In this study, we performed whole-genome gene expression profiling using RNA-Seq to determine the differentially expressed genes in a mammalian cell line after exposure to Ricinus Communis leaf extract & elucidate their pharmacological effects in order to support its ethnomedicinal uses. Various genes involved in cancer, inflammation, atherosclerosis & diabetes were found to be differentially regulated after exposure to sub-lethal concentrations of the RC extract in MCF7 cells.

   • According to Abdul WM (2018)

     Excerpt communis harbours phytochemicals which have been shown to target peroxisome proliferator activated receptor (PPAR), nuclear factor NF- κ -B, cytochrome p450, P38 Mitogen-activated protein kinases kinase (p38 MAPK), tumor protein P53, B-cell lymphoma-extra-large (Bcl-xL) and vascular endothelial growth factor receptor-2 (VEGFR-2). These phytochemicals have been responsible for pharmacological and therapeutic effects, including anticancer, antimicrobial, insecticidal, antioxidant, anti-diabetic, antinociceptive, anti-inflammatory, bone regenerative, analgesic & anticonvulsant activity.

2. 2

   Cancer: adjuvant treatment of colorectal, breast and liver cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Aslani MR (2007)

     Excerpt Pathology revealed severe gastroenteritis, cardiac haemorrhage & necrosis, hepatic necrosis & acute tubular necrosis in kidneys.

   • According to Majumder M (2019)

     Excerpt Here, we report the anti-cancer efficacy of Ricinus communis fruit extract (RCFE) using estrogen positive MCF-7 & highly aggressive, triple negative MDA-MB-231 breast cancer cells. Overall, this study for the first time demonstrates the anti-cancer efficacy of the fruit extract of common castor plant which can be proposed as a potent candidate for the treatment of breast cancer.

   • According to Soto KM (2069)

     Excerpt communis) leaves (AuNPsCE) ethanolic extracts in human HT29 & SW480 colorectal cancer cells. communis extracts to synthesize AuNPs, displaying a stronger antiproliferative effect than AuNPsCS.

   • According to Al-Mamun AM (2016)

     Excerpt Ricinus communis (Euphorbiaceae) has previously been reported to possess analgesic, antihistamine, antioxidant & anti-inflammatory activities. communis seed protein on EAC cells was determined by hemocytometer counting using trypan blue dye & DAPI (4΄, 6-diamidino-2-phenylindole) staining was used to assess apoptotic cells.

   • According to Prakas E (2013)

     Excerpt The objective of the present study was to evaluate the in-vitro anti- cancer effects of ethanolic extract of three plant species namely Ricinus communis, Euphorbia helioscopia, Jatropha curcas of the family Euphorbiaceae by SRB assay against seven human cancer cell lines. Colon cancer cell line (Colon HT-29, SW-20, SiHa, Colon 502717), Liver cancer cell line (Hep-2), Breast cancer cell line (T-47D), Cervix cancer cell line OVCAR-5, Prostate cancer cell line (PC-3) & Lungs (AF-49).

3. 3

   Bacterial and fungal infections: Pseudomonas aeruginosa, Candida albicans

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Santos PM (2018)

     Excerpt cereus, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella choleraesuis, Candida albicans & C. The objective of this study was to apply a detailed multiplatform-based metabolite profiling approach to identify antioxidant & antimicrobial compounds in Ricinus communis extracts.

   • According to Abbas M (2018)

     Excerpt communis along with antioxidant & antimicrobial activities. communis methanolic extracts revealed mild mutagenicity against TA98 (range 1975 ± 67 to 2628 ± 79 revertant colonies) & TA100 (range 2773 ± 92 to 3461 ± 147 revertant colonies) strains and these values were 3267 ± 278 & 4720 ± 346 revertant colonies in case of TA98 & TA100 positive controls, respectively.

   • According to Manaf AA (1996)

     Excerpt Antiviral activity against both viruses was present in the extracts from Calotropis gigantea, Costus speciosus, Eugenia micheli, Hedyotis auricularia, Mentha arvensis, Orthosiphon aristatus, Polygonum minus, Ricinus communis (MIG: 0.002-0.1 mg/ml). Antiviral activity was tested against the herpès simplex type-1 (HSV-1) & Vesicular stomatitis (VSV) viruses & cytotoxicity was assayed using the HeLa cell line.

   • According to Al-Mamun AM (2016)

     Excerpt In vitro susceptibility of four human pathogenic bacteria including Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes & Staphylococcus aureus was detected using disk diffusion assay, & minimum inhibitory concentration (MIC) value was determined using micro-dilution method. Ricinus communis (Euphorbiaceae) has previously been reported to possess analgesic, antihistamine, antioxidant & anti-inflammatory activities.

   • According to Donkor AM (2018)

     Excerpt Antibacterial activities of the extracts of three medicinal plants, Senna alata, Ricinus communis & Lannea barteri from two different extractants were studied. Findings support the traditional use of S alata, R communis & L barteri for the treatment of skin & wound infections & form a strong basis for further exploration of these plants,.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.