Ruellia tuberosa (Pat-kanna) : medicinal properties in alcoholic extraction

Ruellia tuberosa (Pat-kanna, Ti-Patat, Duck’s foot, small potato, Patte-à-canard, petite patate) — family Acanthacées.

Scientific synonyms : Cryphacienthus barbadensis—Nees, Dipteracanthus clandestinus-C. Presl.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 42 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Arirudran B (n.d.)

     Excerpt tuberosa exhibited significant protective effect from hepatic damage in N-Nitrosodiethylamine induced hepatotoxicity model. The present study aims to carry out a systematic investigation of the protective influences of the ethyl acetate & ethanolic extract of R .tuberosa against N-Nitrosodiethylamine-induced hepatocarcinogenesis in Wistar albino rats.

   • According to Chang WC (2018)

     Excerpt However, both RTLW & RTLE significantly normalized the expression of hepatic phase I detoxification enzymes such as CYP 2E1 & expression of phase II detoxification enzymes such as UGT 1A7 & GST M1 in diabetic rats. The present study suggests that RTL may ameliorate abnormal hepatic detoxification function via alleviating hyperglycemia & enhancing hepatic antioxidant capacity in HFD/STZ-induced diabetic rats.

   • According to Rajan M (2012)

     Excerpt Rajan M et al, Antidiabetic, Antihyperlipidaemic & hepatoprotective activity of methanolic extract of Ruellia tuberosa Linn leaves in normal and alloxan induced diabetic rats, J of Chem & Pharmaceut Res, 2012, 4(6):2860-8.

   • According to Nur A (n.d.)

     Excerpt Nur A et al, The Effects of Root Extract Ruellia tuberosa L on Histopathology & Malondialdehyde Levels on the Liver of Diabetic Rats, IOP Conf Series: Materials Science & Engineering, Vol 299,.

   • According to Reddy Vennapusa N (2013)

     Excerpt Antitumor activity of methanolic extracts of 250, 500 mg/kg of R tuberosa leaves was evaluated against Ehrlich ascites carcinoma (EAC) tumor in mice. Aim of the present study to evaluate the antitumor effect of Ruellia tuberosa.

2. 2

   Normalisation of serum parameters: AST, ALT, ALP

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Arirudran B (n.d.)

     Excerpt tuberosa exhibited significant protective effect from hepatic damage in N-Nitrosodiethylamine induced hepatotoxicity model. The present study aims to carry out a systematic investigation of the protective influences of the ethyl acetate & ethanolic extract of R .tuberosa against N-Nitrosodiethylamine-induced hepatocarcinogenesis in Wistar albino rats.

   • According to Chang WC (2018)

     Excerpt However, both RTLW & RTLE significantly normalized the expression of hepatic phase I detoxification enzymes such as CYP 2E1 & expression of phase II detoxification enzymes such as UGT 1A7 & GST M1 in diabetic rats. The present study suggests that RTL may ameliorate abnormal hepatic detoxification function via alleviating hyperglycemia & enhancing hepatic antioxidant capacity in HFD/STZ-induced diabetic rats.

   • According to Rajan M (2012)

     Excerpt Rajan M et al, Antidiabetic, Antihyperlipidaemic & hepatoprotective activity of methanolic extract of Ruellia tuberosa Linn leaves in normal and alloxan induced diabetic rats, J of Chem & Pharmaceut Res, 2012, 4(6):2860-8.

   • According to Nur A (n.d.)

     Excerpt Nur A et al, The Effects of Root Extract Ruellia tuberosa L on Histopathology & Malondialdehyde Levels on the Liver of Diabetic Rats, IOP Conf Series: Materials Science & Engineering, Vol 299,.

   • According to CHAITANYA BK (2012)

     Excerpt To study the efficacy of Ruellia tuberosa ethanolic extract (RTEE2012) in reducing the cholesterol levels & as an antioxidant in hypercholesterolemic rats. Plasma lipid profile, hepatic superoxide dismutase (SOD) activity, catalase activity and extent of lipid peroxidation in the form of Malondialdehyde were estimated using standard methods.

3. 3

   Type II diabetes mellitus

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Manikandan A (2010)

     Excerpt The study was undertaken to investigate the effect of 50% hydro -ethanolic leaf extracts of Ruellia tuberosa & Dipteracanthus patulus on lipid profile in alloxan induced diabetic rats. Extracts were orally administered daily for 30 days at a dosage of 250 & 500 mg/kg bodyweight to alloxan induced diabetic rats.

   • According to Roskiana A (n.d.)

     Excerpt This study aimed to determine the influence of ethanolic root extracts of Ruellia tuberosa L on protease activity & MDA levels on pancreatic diabetic rats. The results showed that ethanolic root extracts of R tuberosa at dose of 250 mg/kg BW was the best dose to decrease significantly protease activity & MDA level in the pancreas of diabetic rats with the percentages of 52.11% & 50.54%, respectively.

   • According to Chang WC (2018)

     Excerpt The present study suggests that RTL may ameliorate abnormal hepatic detoxification function via alleviating hyperglycemia & enhancing hepatic antioxidant capacity in HFD/STZ-induced diabetic rats. Male Wistar rats were fed a high fat diet (HFD) & intraperitoneally injected with streptozotocin (STZ) to induce diabetes.

   • According to Ko CY (2018)

     Excerpt We investigated the effect of RTL aqueous & ethanolic extracts on hypoglycemia in high‐fat diet (HFD) ‐fed plus streptozotocin (STZ) ‐induced T2DM rats, & examined the effect of RTL on glucose uptake in tumor necrosis factor‐α‐induced insulin‐resistant mouse C2C12 myoblasts, a mouse skeletal muscle cell line. The administration of 100 or 400 mg kg BW⁻¹ day⁻¹ of RTL aqueous or ethanolic extracts once a day for 4 weeks significantly ameliorated hyperglycemia, hyperinsulinemia & the insulin resistance (IR) index in diabetic rats.

   • According to Manikandan A (2013)

     Excerpt & Dipteracanthus Patulus (Jacq.) on Lipid Profile in Alloxan Induced Diabetic Rats, Int J Prev Med., 2013; 4(7) : 744–7. Manikandan A et al, Effect of 50% Hydroethanolic Leaf Extracts of Ruellia Tuberosa L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.