Schinus terebenthifolius (Pwèv-Brézil) : medicinal properties in alcoholic extraction

Schinus terebenthifolius (Pwèv-Brézil, Brazilian pepper, Poivre du Brésil) — family Anacardiacées.

Scientific synonyms : Schinus terbinthifolia var. damaziana-Beauverd.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 57 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, cirrhosis, fatty liver, liver detoxification

   Plant part used: above-ground parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KHALIL W (2015)

     Excerpt The present study was conducted to investigate the curative & protective effects of Schinus terebenthifolius ethanolic extract against CCl4 -induced acute hepatotoxicity in rats. CCl4 increased liver enzyme leakage, oxidative stress, hepatic apoptosis, DNA oxidation, & inflammatory markers.

   • According to Abdou RH (n.d.)

     Excerpt The present study was conducted to investigate the curative & protective effects of Schinus terbenthifolius ethanolic extract against CCl4 -induced acute hepatotoxicity in rats. Results: CCl4 increased liver enzyme leakage, oxidative stress, hepatic apoptosis, DNA oxidation, & inflammatory markers.

   • According to Dos Santos da Rocha P (2019)

     Excerpt After showing no acute toxicity in vivo, MESL was able to lower postprandial glycemia after glucose overload in normoglycemic mice as well as the water & feed intake, liver weight, glycemia & serum levels of glycated hemoglobin, aspartate transaminase (AST) & alanine transaminase (ALT) in diabetic mice. The objective of this study was to assess the microbiological quality, safety, chemical profile as well as antioxidant & antidiabetic potentials of different parts of S.

   • According to Salem MZM (2018)

     Excerpt The toxicity against the growth of Acinetobacter baumannii, Bacillus subtilis, Escherichia coli, Micrococcus flavus, Pseudomonas aeruginosa, Sarcina lutea, & Staphylococcus aureus was determined with measuring the inhibition zones (IZs) using the disc diffusion method at the concentrations from 125 to 2000 μg/mL, also, the minimum inhibitory concentrations (MICs) using 96-well micro-plates & ranged from 4 to 2000 μg/mL. aeruginosa with MIC values of 16 μg/mL & 32 μg/mL, the ACE showed broad activity against the studied bacterial pathogens with MIC values ranged from of 4-128 μg/mL against the studied bacterial isolates, while HexE, however, showed weak antibacterial activity.

   • According to El-Nashar HAS (2022)

     Excerpt Besides, some Schinus species & their isolated active compounds showed important biological activities such as antibacterial, antifungal, insecticidal, antiparasitic, analgesic, cytotoxic, antitumor, antioxidant, antihypertensive, anti-inflammatory, antimycobacterial, anti-Parkinson, anti-allergic, antiviral, wound healing, chemoprotective, anthelmintic & hepatoprotective. Traditionally, Schinus plants are used to alleviate several & diverse diseases including rheumatism, hypertension, ulcers, gastric distress, menstrual disorders, gonorrhea, bronchitis, gingivitis, conjunctivitis, dysentery, wounds, urinary tract, & eye infections.

2. 2

   Cancer: adjuvant treatment for leukaemic and breast carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bendaoud J (2010)

     Excerpt Essential oils were also evaluated for their anticancer activities against human breast cancer cells (MCF-7). & Schinus terebinthifolius Raddi originating from southern of Tunisia & analyzed by GC-FID & GC-MS.

   • According to Bulla MK (2015)

     Excerpt Schinus terebinthifolius is a plant rich in phenolic compounds, which have antioxidant properties & can provide new opportunities for treatment & prevention of diseases mediated by ultraviolet radiation like photoaging & skin cancer.

   • According to Santana JS (2012)

     Excerpt These compounds, including hydrogenation (pinane) & epoxydation (α-pinene oxide) derivatives from α-pinene, were tested in vitro against murine melanoma cell line (B16F10-Nex2) & human melanoma (A2058), breast adenocarcinoma (MCF7), leukemia (human leukemia (HL-60) & cervical carcinoma (HeLa) cell lines. The crude essential oil showed cytotoxic effects in several cell lines, mainly on leukemia & human cervical carcinoma.

   • According to Cruz-Rosas E (2015)

     Excerpt Additionally, ST-70 inhibited synovial interleukin (IL)-6, IL-1β, keratinocyte-derived chemokine (CXCL1/KC) & Tumor Necrosis Factor (TNF)-α production at 6h & CXCL1/KC & IL-1β production at 24h. Schinus terebinthifolius is a species of plant from the Anacardiaceae family, which can be found in different regions of Brazil.

   • According to Dos Santos da Rocha P (2018)

     Excerpt Doxorubicin is an anticancer drug whose toxic effects on non-cancer cells are associated with increased oxidative stress. This study investigated the chemical composition, antioxidant activity of the methanolic extract of Schinus terebinthifolius leaves (MESL) as well as effects against doxorubicin-induced toxicity in human erythrocytes, K562 human erythroleukemia cells, & mouse hearts.

3. 3

   Periodontitis, tooth decay, dental plaque: Aggregatibacter actinomycetemcomitans, Streptococcus mutans, Staphylococcus aureus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pereira EMR (2011)

     Excerpt This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, & Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebenthifolius, Croton campestris, Lafoensia pacari (pacari), Centaurium erythraea, Stryphnodendron adstringens (barbatimão), & Anacardium humile, as compared to standardized antimicrobial agents (nystatin, chloramphenicol & tetracycline hydrochloride). This study suggests that extracts from the plants tested could be an alternative therapeutic option for infectious conditions of the oral cavity, such as denture stomatitis, dental caries, & periodontitis.

   • According to Uliana MP (2016)

     Excerpt All extracts showed strong antimicrobial activity against Staphylococcus aureus & Escherichia coli. The leaves of Schinus terebinthifolius Raddi (Anacardiaceae), the Brazilian pepper tree, are widely used in folk medicine for treating human diseases caused by microorganisms.

   • According to Salem MZM (2018)

     Excerpt The toxicity against the growth of Acinetobacter baumannii, Bacillus subtilis, Escherichia coli, Micrococcus flavus, Pseudomonas aeruginosa, Sarcina lutea, & Staphylococcus aureus was determined with measuring the inhibition zones (IZs) using the disc diffusion method at the concentrations from 125 to 2000 μg/mL, also, the minimum inhibitory concentrations (MICs) using 96-well micro-plates & ranged from 4 to 2000 μg/mL.

   • According to Dos Santos GD (2021)

     Excerpt Xylaria allantoidea CMRP1424 extracts showed antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, & Staphylococcus aureus. In this study, endophytic fungi were isolated from Schinus terebinthifolius to investigate their diversity & antimicrobial activity.

   • According to Cole (2014)

     Excerpt The antibacterial activity of the essential oil was evaluated against wild strains of hospital origin (Escherichia coli, Pseudomonas sp., Klebsiella oxytoca, Corynebacterium sp., Staphylococcus aureus, Enterobacter sp., Enterobacter agglomerans, Bacillus sp., Nocardia sp.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.