Scoparia dulcis (Balié-dou) : medicinal properties in alcoholic extraction

Scoparia dulcis (Balié-dou, Balai-doux) — family Scrofulariacées.

Scientific synonyms : Capraria dulcis-(L)-Kuntze, Gratiola micrantha-Nutt, Scoparia grandiflora-Nash, Scoparia ternata-Forsk.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 41 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Latha M (2015)

     Excerpt We evaluated the antihyperglycaemic effect of Scoparic acid D (SAD), a diterpenoid isolated from the ethanol extract of Scoparia dulcis in streptozotocin (STZ)-induced diabetic male Wistar rats. At the end of the experimental period, the SAD-treated STZ diabetic rats showed decreased levels of glucose as compared with diabetic control rats.

   • According to Zulfiker AHM (2010)

     Excerpt Hence, the present study was designed to evaluate antidiabetic & antioxidant principle of the ethanolic extract of S dulcis (EESD) for its antidiabetic & antioxidant potential against alloxan-induced diabetic mice. These results demonstrate the antidiabetic and antioxidant potential of ethanolic extracts of S dulcis & suggests that the plant may have therapeutic value in diabetes & related complications.

   • According to Latha M (2004)

     Excerpt Administration of an aqueous extract of SD by intragastric intubation (po) at a dose of 200 mg/kg body weight significantly decreased the blood glucose & lipid peroxidative marker thiobarbituric acid reactive substances (TBARS) with significant increase in the activities of plasma insulin, pancreatic superoxide dismutase (SOD), catalase (CAT), & reduced glutathione (GSH) in streptozotocin diabetic rats at the end of 15 days treatment. Streptozotocin at a dose of 10 mug/mL evoked 6-fold stimulation of insulin secretion from isolated islets indicating its insulin secretagogue activity.

   • According to Latha M (2014)

     Excerpt The administration of an aqueous extract of SD at a dose of 200 mg/kg body weight significantly decreased the blood glucose with significant increase in plasma insulin level in streptozotocin diabetic rats at the end of 15 days treatment. Scoparia dulcis (Sweet Broomweed) has been documented as a traditional treatment of diabetes.

   • According to Pari L (2002)

     Excerpt Scoparia dulcis commonly known as ‘Sweet Broomweed’ is widely used in Indian folk medicine for the treatment of diabetes mellitus. An oral glucose tolerance test was also performed in experimental diabetic rats, in which there was a significant improvement in glucose tolerance in animals treated with SLEt & the effect was comparable to that of glibenclamide,.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hayashi T (1992)

     Excerpt The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver.

   • According to Tsai JC (2010)

     Excerpt This study aims to investigate the hepatoprotective activity and active constituents of the ethanol extract of Scoparia dulcis (SDE). The hepatoprotective effect of SDE (0.1, 0.5 and 1 g/kg) was evaluated on the carbon tetrachloride (CCl(4))-induced acute liver injury.

   • According to Praveen TK (2009)

     Excerpt Praveen TK et al, Hepatoprotective activity of petroleum ether, diethyether & methanol extract of Scoparia dulcis L. against carbon tetrachloride-induced acute liver injury in mice.

   • According to Author (2015)

     Excerpt dulcis (SD) is a perennial herb that has been well studied for its antioxidant, antiinflammatory, antidiabetic, & hepatoprotective effects. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of S dulcis (EESD).

   • According to Tsai JC (2011)

     Excerpt The aims of this study intended to investigate the antiinflammatory activity of the 70% ethanol extract from Scoparia dulcis (SDE) & betulinic acid on λ-carrageenan-induced paw edema in mice. The antiinflammatory mechanism of SDE & betulinic acid was examined by detecting the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and Malondialdehyde (MDA) in the edema paw tissue & the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione réductase (GRd) in the liver.

3. 3

   Adjuvant treatment for cholangiocarcinoma

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nishino H (1993)

     Excerpt Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from a medicinal plant, Scoparia dulcis L., inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro & in vivo; SDB inhibited TPA-enhanced phospholipid synthesis in cultured cells, & also suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. The potency of SDB proved to be stronger than that of other natural antitumor-promoting terpenoids, such as glycyrrhetinic acid.

   • According to Serpoioni JM (2022)

     Excerpt The present study investigates the mechanisms underlying the in vitro antitumoral activity of cirsimarin (CIR 10 to 320 μM), a flavone extracted from the aerial parts of Scoparia dulcis L., on MCF-7 cells cultured in 2D & multicellular tumor spheroids (3D). BIRC5 & CDKs inhibitors have been proposed as versatile anticancer drugs, which makes our results quite interesting.

   • According to Tsai JC (2011)

     Excerpt The aims of this study intended to investigate the antiinflammatory activity of the 70% ethanol extract from Scoparia dulcis (SDE) & betulinic acid on λ-carrageenan-induced paw edema in mice. The antiinflammatory mechanism of SDE & betulinic acid was examined by detecting the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and Malondialdehyde (MDA) in the edema paw tissue & the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione réductase (GRd) in the liver.

   • According to Promraksa B (2019)

     Excerpt Cardiospermum halicacabum, Gomphrena celosioides & Scoparia dulcis, very well-known medicinal herbs in Asian countries, were selected for the investigation of inhibitory effects on cholangiocarcinoma (CCA) cells. dulcis extract showed most inhibitory effects on cell growth of CCA cell lines KKU-100 1 KKU-213, at percentages of 56.06 & 74.76, respectively, compared to the untreated group after treatment with 250 μg/mL of extracts for 72 hrs.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.