Scoparia dulcis (Balié-dou) : vertus médicinales en extraction alcoolique

Scoparia dulcis (Balié-dou, Balai-doux) — famille Scrofulariacées.

Synonymes scientifiques : Capraria dulcis-(L)-Kuntze, Gratiola micrantha-Nutt, Scoparia grandiflora-Nash, Scoparia ternata-Forsk.

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 17 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 41 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Latha M (2015)

     Extrait We evaluated the antihyperglycaemic effect of Scoparic acid D (SAD), a diterpenoid isolated from the ethanol extract of Scoparia dulcis in streptozotocin (STZ)-induced diabetic male Wistar rats. At the end of the experimental period, the SAD-treated STZ diabetic rats showed decreased levels of glucose as compared with diabetic control rats.

   • Selon Zulfiker AHM (2010)

     Extrait Hence, the present study was designed to evaluate antidiabetic & antioxidant principle of the ethanolic extract of S dulcis (EESD) for its antidiabetic & antioxidant potential against alloxan-induced diabetic mice. These results demonstrate the antidiabetic and antioxidant potential of ethanolic extracts of S dulcis & suggests that the plant may have therapeutic value in diabetes & related complications.

   • Selon Latha M (2004)

     Extrait Administration of an aqueous extract of SD by intragastric intubation (po) at a dose of 200 mg/kg body weight significantly decreased the blood glucose & lipid peroxidative marker thiobarbituric acid reactive substances (TBARS) with significant increase in the activities of plasma insulin, pancreatic superoxide dismutase (SOD), catalase (CAT), & reduced glutathione (GSH) in streptozotocin diabetic rats at the end of 15 days treatment. Streptozotocin at a dose of 10 mug/mL evoked 6-fold stimulation of insulin secretion from isolated islets indicating its insulin secretagogue activity.

   • Selon Latha M (2014)

     Extrait The administration of an aqueous extract of SD at a dose of 200 mg/kg body weight significantly decreased the blood glucose with significant increase in plasma insulin level in streptozotocin diabetic rats at the end of 15 days treatment. Scoparia dulcis (Sweet Broomweed) has been documented as a traditional treatment of diabetes.

   • Selon Pari L (2002)

     Extrait Scoparia dulcis commonly known as ‘Sweet Broomweed’ is widely used in Indian folk medicine for the treatment of diabetes mellitus. An oral glucose tolerance test was also performed in experimental diabetic rats, in which there was a significant improvement in glucose tolerance in animals treated with SLEt & the effect was comparable to that of glibenclamide,.

2. 2

   Hépatite, cirrhose, stéatose hépatique

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hayashi T (1992)

     Extrait The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver.

   • Selon Tsai JC (2010)

     Extrait This study aims to investigate the hepatoprotective activity and active constituents of the ethanol extract of Scoparia dulcis (SDE). The hepatoprotective effect of SDE (0.1, 0.5 and 1 g/kg) was evaluated on the carbon tetrachloride (CCl(4))-induced acute liver injury.

   • Selon Praveen TK (2009)

     Extrait Praveen TK et al, Hepatoprotective activity of petroleum ether, diethyether & methanol extract of Scoparia dulcis L. against carbon tetrachloride-induced acute liver injury in mice.

   • Selon Auteur (2015)

     Extrait dulcis (SD) is a perennial herb that has been well studied for its antioxidant, antiinflammatory, antidiabetic, & hepatoprotective effects. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of S dulcis (EESD).

   • Selon Tsai JC (2011)

     Extrait The aims of this study intended to investigate the antiinflammatory activity of the 70% ethanol extract from Scoparia dulcis (SDE) & betulinic acid on λ-carrageenan-induced paw edema in mice. The antiinflammatory mechanism of SDE & betulinic acid was examined by detecting the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and Malondialdehyde (MDA) in the edema paw tissue & the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione réductase (GRd) in the liver.

3. 3

   Cancer traitement adjuvant du cholangiocarcinome

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Nishino H (1993)

     Extrait Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from a medicinal plant, Scoparia dulcis L., inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro & in vivo; SDB inhibited TPA-enhanced phospholipid synthesis in cultured cells, & also suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. The potency of SDB proved to be stronger than that of other natural antitumor-promoting terpenoids, such as glycyrrhetinic acid.

   • Selon Serpoioni JM (2022)

     Extrait The present study investigates the mechanisms underlying the in vitro antitumoral activity of cirsimarin (CIR 10 to 320 μM), a flavone extracted from the aerial parts of Scoparia dulcis L., on MCF-7 cells cultured in 2D & multicellular tumor spheroids (3D). BIRC5 & CDKs inhibitors have been proposed as versatile anticancer drugs, which makes our results quite interesting.

   • Selon Tsai JC (2011)

     Extrait The aims of this study intended to investigate the antiinflammatory activity of the 70% ethanol extract from Scoparia dulcis (SDE) & betulinic acid on λ-carrageenan-induced paw edema in mice. The antiinflammatory mechanism of SDE & betulinic acid was examined by detecting the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and Malondialdehyde (MDA) in the edema paw tissue & the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione réductase (GRd) in the liver.

   • Selon Promraksa B (2019)

     Extrait Cardiospermum halicacabum, Gomphrena celosioides & Scoparia dulcis, very well-known medicinal herbs in Asian countries, were selected for the investigation of inhibitory effects on cholangiocarcinoma (CCA) cells. dulcis extract showed most inhibitory effects on cell growth of CCA cell lines KKU-100 1 KKU-213, at percentages of 56.06 & 74.76, respectively, compared to the untreated group after treatment with 250 μg/mL of extracts for 72 hrs.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.