Sechium edule (Kristofin) : medicinal properties in alcoholic extraction

Sechium edule (Kristofin, Christophine) — family Cucurbitacées.

Scientific synonyms : Chayota edulis-Jacq, Sicyos edulis-Jacq.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 47 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: normalisation of serum parameters: ALP, ALT, AST, bilirubin, hepatitis, cirrhosis, fatty liver

   Plant part used: fruit pulp.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Firdous SM (2012)

     Excerpt Ethanolic extract of fruits of Sechium edule and its different fractions (200 mg/kg, p.o) showed a remarkable hepatoprotective activity against paracetamol induced hepatotoxicity in mice by significantly (P<0.01) reducing the levels of AST, ALT, ALP, total Bilirubin & significantly (P<0.01) increasing the serum total protein. The ethanolic extract of fruits of SE & its different fractions (200 mg/kg, p.o) also improve the histoarchitectural of the liver which was confirmed by histopathological examination.

   • According to Siska V (2020)

     Excerpt This study will measure MDA levels as a biomarker of oxidative stress, IL-6 as a sign of inflammation, bodyweight as obesity, leptin levels as a biomarker of appetite & lipid profile levels.

   • According to Alvarado-Ojeda ZA (2022)

     Excerpt A hydroalcoholic extract of Sechium edule root (rSe-HA), standardized for its cinnamic acid content, was used to control the incidence of liver damage in mice (11 mg/kg/day of rSe-HA, administered orally). Meanwhile, ANGII treatment increased serum TG concentration (62.8%), alanine aminotransaminase (GPT/ALT) levels (206%), as well as TG accumulation (82.7%), hepatomegaly (32.1%), inflammation (measured by TNFα (70%), IL-1β (103%), IL-6 (92%), & TGFβ (203%) levels, along with inflammatory cell recruitment), and fibrosis with respect to untreated controls.

   • According to Dire G (2003)

     Excerpt We evaluated the influence of a chayotte (Sechium edule) extracts (decoct and macerated) on the radio labeling of blood elements and on the bioavailability of 99mTcO4Na. Sechium edule (chayotte) is a vegetable very spent in the human nutrition as the popular medicine due its properties such as the diuretic and the hypotensor effects.

   • According to Daulay AS (2021)

     Excerpt Daulay AS et al, Antioxidant Activity Test of Chayote (Sechium edule (Jacq.) Swartz) Ethanol Extract using DPPH Method, J of Physics Conf Series, 1819: 012035, 2021- Abstract. The chayote (Sechium edule (Jacq.) Swartz) is thought to have excellent antioxidant activity.

2. 2

   Type 2 diabetes mellitus, obesity

   Plant part used: fruit pulp.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Maity S (2013)

     Excerpt The objective of this study was to investigate the effect of ethanolic extract of Sechium edule fruits on alloxan induced diabetes in Wistar rats. The lipid profile of diabetic rats was also improved on administration of ethanolic extract of Sechium edule fruits.

   • According to Siahaan JM (2016)

     Excerpt Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic E cells.

   • According to Tiwari KA (2013)

     Excerpt This research explored preventive & therapeutic potentials of fruit juice of Benincasa hispida (BH) & Sechium edule (SE) in fructose & sucrose-sweetened beverages induced impaired glucose tolerance (IGT), oxidative stress & IGT induced other metabolic disturbances in rats. Conclusion: Our observations reveal that consumption of BH & SE juice may help reduce development of hyperglycemia & hyperglycemia induced development of complications by virtue of their antihyperglycemic & antioxidative stress potentials.

   • According to Siska V (2020)

     Excerpt The research was conducted at the Biomedical Laboratory of FK UMI & started the acclimatization process, giving experimental animal surgery treatment at the animal house of FK UMI Results: The results of the study concluded that the effect of SE ethanol extract can affect oxidative stress which has potential as anti-obesity & hypolipidemia & antioxidant. The purpose of this study was to analyze the effect of ethanolic extract of chayote on oxidative stress of obese white rats of wistar strain (Rattus novergius Sp.) induced by a high fatty diet.

   • According to Alvarado-Ojeda ZA (2022)

     Excerpt A hydroalcoholic extract of Sechium edule root (rSe-HA), standardized for its cinnamic acid content, was used to control the incidence of liver damage in mice (11 mg/kg/day of rSe-HA, administered orally). After 11 weeks, the mice were sacrificed & adipose tissue, serum, & liver were obtained.

3. 3

   Hypertension with renal impairment in diabetic patients

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Siahaan JM (2016)

     Excerpt Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic E cells. This study aimed to determine the effect of Ethanol Extract of Chayote ((EEBLS) Ekstrak Etanol Buah Labu Siam) on decreasing blood sugar content & increasing the activity of glutathione peroxide enzyme.

   • According to Maity S (2013)

     Excerpt The objective of this study was to investigate the effect of ethanolic extract of Sechium edule fruits on alloxan induced diabetes in Wistar rats. The lipid profile of diabetic rats was also improved on administration of ethanolic extract of Sechium edule fruits.

   • According to Lombardo-Earl G (2014)

     Excerpt Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. Vagotomized rats were administered different doses of AG II as well as the Hydroalcoholic extract, which reduced blood pressure in 30 mmHg approximately; Subsequently this extract was separated into two fractions (acetone a&methanol) which were evaluated in the acute hypertension mouse model induced with AG II, where the acetone fraction was identified as the most effective one & was Subsequently sub-fractioned using an open chromatographic column packed with silica gel.

   • According to Tiwari KA (2013)

     Excerpt This research explored preventive & therapeutic potentials of fruit juice of Benincasa hispida (BH) & Sechium edule (SE) in fructose & sucrose-sweetened beverages induced impaired glucose tolerance (IGT), oxidative stress & IGT induced other metabolic disturbances in rats. Shape of plasma glucose concentration curve following OGTT, glycemic load, plasma total antioxidant potential (TAOP), oxidative stress status, platelet aggregation activity &, advanced glycation end-products (AGEs) level in blood of rats were examined.

   • According to Daulay AS (2021)

     Excerpt Daulay AS et al, Antioxidant Activity Test of Chayote (Sechium edule (Jacq.) Swartz) Ethanol Extract using DPPH Method, J of Physics Conf Series, 1819: 012035, 2021- Abstract. The chayote (Sechium edule (Jacq.) Swartz) is thought to have excellent antioxidant activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.