Sechium edule (Kristofin) : vertus médicinales en extraction alcoolique

Sechium edule (Kristofin, Christophine) — famille Cucurbitacées.

Synonymes scientifiques : Chayota edulis-Jacq, Sicyos edulis-Jacq.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 19 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 47 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Troubles hépatiques : normalisation des paramètres sériques :ALP, ALT, AST, bilirubine, hépatite, cirrhose, stéatose hépatique

   Partie usitée : pulpe du Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Firdous SM (2012)

     Extrait Ethanolic extract of fruits of Sechium edule and its different fractions (200 mg/kg, p.o) showed a remarkable hepatoprotective activity against paracetamol induced hepatotoxicity in mice by significantly (P<0.01) reducing the levels of AST, ALT, ALP, total Bilirubin & significantly (P<0.01) increasing the serum total protein. The ethanolic extract of fruits of SE & its different fractions (200 mg/kg, p.o) also improve the histoarchitectural of the liver which was confirmed by histopathological examination.

   • Selon Siska V (2020)

     Extrait This study will measure MDA levels as a biomarker of oxidative stress, IL-6 as a sign of inflammation, bodyweight as obesity, leptin levels as a biomarker of appetite & lipid profile levels.

   • Selon Alvarado-Ojeda ZA (2022)

     Extrait A hydroalcoholic extract of Sechium edule root (rSe-HA), standardized for its cinnamic acid content, was used to control the incidence of liver damage in mice (11 mg/kg/day of rSe-HA, administered orally). Meanwhile, ANGII treatment increased serum TG concentration (62.8%), alanine aminotransaminase (GPT/ALT) levels (206%), as well as TG accumulation (82.7%), hepatomegaly (32.1%), inflammation (measured by TNFα (70%), IL-1β (103%), IL-6 (92%), & TGFβ (203%) levels, along with inflammatory cell recruitment), and fibrosis with respect to untreated controls.

   • Selon Dire G (2003)

     Extrait We evaluated the influence of a chayotte (Sechium edule) extracts (decoct and macerated) on the radio labeling of blood elements and on the bioavailability of 99mTcO4Na. Sechium edule (chayotte) is a vegetable very spent in the human nutrition as the popular medicine due its properties such as the diuretic and the hypotensor effects.

   • Selon Daulay AS (2021)

     Extrait Daulay AS et al, Antioxidant Activity Test of Chayote (Sechium edule (Jacq.) Swartz) Ethanol Extract using DPPH Method, J of Physics Conf Series, 1819: 012035, 2021- Abstract. The chayote (Sechium edule (Jacq.) Swartz) is thought to have excellent antioxidant activity.

2. 2

   Diabète mellitus de type II obésité

   Partie usitée : pulpe du Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Maity S (2013)

     Extrait The objective of this study was to investigate the effect of ethanolic extract of Sechium edule fruits on alloxan induced diabetes in Wistar rats. The lipid profile of diabetic rats was also improved on administration of ethanolic extract of Sechium edule fruits.

   • Selon Siahaan JM (2016)

     Extrait Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic E cells.

   • Selon Tiwari KA (2013)

     Extrait This research explored preventive & therapeutic potentials of fruit juice of Benincasa hispida (BH) & Sechium edule (SE) in fructose & sucrose-sweetened beverages induced impaired glucose tolerance (IGT), oxidative stress & IGT induced other metabolic disturbances in rats. Conclusion: Our observations reveal that consumption of BH & SE juice may help reduce development of hyperglycemia & hyperglycemia induced development of complications by virtue of their antihyperglycemic & antioxidative stress potentials.

   • Selon Siska V (2020)

     Extrait The research was conducted at the Biomedical Laboratory of FK UMI & started the acclimatization process, giving experimental animal surgery treatment at the animal house of FK UMI Results: The results of the study concluded that the effect of SE ethanol extract can affect oxidative stress which has potential as anti-obesity & hypolipidemia & antioxidant. The purpose of this study was to analyze the effect of ethanolic extract of chayote on oxidative stress of obese white rats of wistar strain (Rattus novergius Sp.) induced by a high fatty diet.

   • Selon Alvarado-Ojeda ZA (2022)

     Extrait A hydroalcoholic extract of Sechium edule root (rSe-HA), standardized for its cinnamic acid content, was used to control the incidence of liver damage in mice (11 mg/kg/day of rSe-HA, administered orally). After 11 weeks, the mice were sacrificed & adipose tissue, serum, & liver were obtained.

3. 3

   HTA avec atteinte rénale chez le patient diabétique

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Siahaan JM (2016)

     Extrait Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic E cells. This study aimed to determine the effect of Ethanol Extract of Chayote ((EEBLS) Ekstrak Etanol Buah Labu Siam) on decreasing blood sugar content & increasing the activity of glutathione peroxide enzyme.

   • Selon Maity S (2013)

     Extrait The objective of this study was to investigate the effect of ethanolic extract of Sechium edule fruits on alloxan induced diabetes in Wistar rats. The lipid profile of diabetic rats was also improved on administration of ethanolic extract of Sechium edule fruits.

   • Selon Lombardo-Earl G (2014)

     Extrait Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. Vagotomized rats were administered different doses of AG II as well as the Hydroalcoholic extract, which reduced blood pressure in 30 mmHg approximately; Subsequently this extract was separated into two fractions (acetone a&methanol) which were evaluated in the acute hypertension mouse model induced with AG II, where the acetone fraction was identified as the most effective one & was Subsequently sub-fractioned using an open chromatographic column packed with silica gel.

   • Selon Tiwari KA (2013)

     Extrait This research explored preventive & therapeutic potentials of fruit juice of Benincasa hispida (BH) & Sechium edule (SE) in fructose & sucrose-sweetened beverages induced impaired glucose tolerance (IGT), oxidative stress & IGT induced other metabolic disturbances in rats. Shape of plasma glucose concentration curve following OGTT, glycemic load, plasma total antioxidant potential (TAOP), oxidative stress status, platelet aggregation activity &, advanced glycation end-products (AGEs) level in blood of rats were examined.

   • Selon Daulay AS (2021)

     Extrait Daulay AS et al, Antioxidant Activity Test of Chayote (Sechium edule (Jacq.) Swartz) Ethanol Extract using DPPH Method, J of Physics Conf Series, 1819: 012035, 2021- Abstract. The chayote (Sechium edule (Jacq.) Swartz) is thought to have excellent antioxidant activity.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.