Senna alata (Kasialata) : medicinal properties in alcoholic extraction

Senna alata (Kasialata, Datié, cassia-alata, dartrier) — family Fabacées.

Scientific synonyms : Cassia alata-L, Herpetica alata-(L)-Raf..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 26 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 130 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Varghese GK (2013)

     Excerpt The identity of the isolated compounds was established by spectroscopic analysis while their potential antidiabetic activity was assessed by in vitro enzyme inhibition studies. Discussion: One of the possible antidiabetic mechanisms of action of CA is by inhibiting carbohydrate digestion.

   • According to Uwazie JN (2020)

     Excerpt Animals in group A received distilled water while those in groups B-F were made diabetic by treatment with 150 mg/kg body weight (b.w.) of alloxan. Animals in Groups B-G were also made diabetic by alloxan treatment.

   • According to Naowaboot J (2017)

     Excerpt The present study investigated the effect of Senna alata leaf extracts on the regulation of abnormal glucose metabolism in HFD-induced obese mice. alata (250 & 500 mg/kg) significantly reduced hyperglycemia, hyperinsulinemia & hyperleptinemia.

   • According to COLIN MN (2024)

     Excerpt However, there has not been significant progress accomplished in terms of the evaluation of the dosage form so that test results for promising activities like antidiabetic, antifungal, & antiviral can be carried out into further research. Twenty pharmacological activities have been identified, with the flavonoid group (emodin, kaempferol, quercetin) as the most prevalent secondary metabolite found in Cassia alata.

   • According to Kazeem MI (2015)

     Excerpt Kazeem MI et al, Effect of Senna alata (L) Roxb (Fabaceae) Leaf Extracts on alpha-Amylase, alpha-Glucosidase & Postprandial Hyperglycemia in Rats, Trop J of Pharmaceut Res, 2015; 14(10):1843-8-http://dx.doi.org/10.4314/tjpr.v14i10.15,.

2. 2

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kudatarkar NM (n.d.)

     Excerpt Studies have found out that people in developed western countries are more prone to colorectal cancer due to their low fiber food habits & sedentary life-styles. In in-vivo studies, colorectal cancer was induced by administering Dimethyl hydrazine (DMH) intraperitoneally to male Wistar rats for 20 weeks.

   • According to Onyegeme-Okerenta B (2018)

     Excerpt Increases Cytotoxicity in the Human Breast, Prostate & Colorectal Cancer Cells, J of Cancer Treatment & Res, 2018; 6(3):44-53-. Onyegeme-Okerenta B et al, Ethyl Acetate Extract of Senna alata (L.) Roxb.

   • According to Chahardehi AM (2021)

     Excerpt In this study, we tested the extract & fractions on brine shrimp lethality test & antiproliferative activity on cancer & normal cell lines. The leaves of Senna alata from the Fabaceae family have been used in folk medicine for the cure of skin disease.

   • According to Amir-Modarrhesi C (2021)

     Excerpt In this study, we tested the extract & fractions on brine shrimp lethality test & antiproliferative activity on cancer & normal cell lines. The leaves of Senna alata from the Fabaceae family have been used in folk medicine for the cure of skin disease.

   • According to Modamesr CA (2021)

     Excerpt Methods: The 80 % ethanolic leaf extract & its fractions were examined for possible cytotoxic effect using sulforhodamine B (SRB) cytotoxicity assay towards breast cancer (MCF-7), normal (MCF10A) cell lines, & brine shrimp lethality test (BSLT). alata crude ethanolic leaf extract a& its fractions potentially contain significant bioactive compounds that are safe from adverse effects, which proves the therapeutic application of S.

3. 3

   Fungal infection: Candida albicans, Aspergillus niger, Penicillium notatum, Microsporum canis, Trichophyton mentagrophytes, Epidermophyton

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SY T (2012)

     Excerpt The minimum inhibitory concentration of the water leaf extract of C alata for Candida albicans, Aspergillus niger, Penicillium notatum, Microsporium canis & Trichophyton mentagrophytes were 26.90 mg, 32.40 mg, 29.50 mg, 30.30 mg and 27.80 mg respectively, while that of ethanol leaf extract of C alata for Candida albicans, Aspergillus niger, Penicillium notatum, Microsporum canis & Trichophyton mentagrophytes were 5.60 mg, 3.50 mg, 4.90 mg, 12.60 mg & 9.80 mg respectively. The extracts inhibited the growth of Candida albicans, Microsporum canis & Trichophyton mentagrophytes better than the Ketoconazole 200 mg used as a positive control (p<0.05).

   • According to Alalor CA (2012)

     Excerpt The assessment of antifungal potential of the aqueous & methanol extracts of sun-dried leaves of Cassia alata was investigated by testing the extracts against some fungi (Candida albicans, Trichophyton mentagrophyte, Aspergillus niger & Penicillium) using the Agar cup plate method. The results showed that the plant part can be used to treat infections caused by fungi (Candida albicans, Trichophyton mentagrophyte & Aspergillus niger) which were susceptible.

   • According to Sule WF (2010)

     Excerpt The results obtained showed that the leaf exudates and the ethanol extract of the leaf of S alata exhil: had marked antifungal effects on Microsporum canis, Trichophyton jirrucosum, Trichophyton mentagrophytes & Epidermophyton jlorrcosum. The test was conducted on Dermatophytes which included Dermatophytes of the genera Trichophyton, Microsporum & Epidermophyton.

   • According to Somchit MN (2003)

     Excerpt Crude ethanol & water extract of leaves & barks from Cassia alata were tested in vitro against fungi, (Aspergillus fumigatus & Microsporum canis), yeast (Candida albicans) & bacteria (Staphylococcus aureus & Escherichia coli). albicans showed concentration-dependent susceptibility towards both the ethanol & water extracts from the barks, but resistant towards the extracts of leaves.

   • According to Ibrahim D (1995)

     Excerpt mentagorophytes, Trichophyton rubrum & Microsporum gypseum had the MIC of 125 mg/ml, whereas Microsporum canis had the MIC of 62.5 mg/ml. Ethanolic extract of Cassia alata leaves was investigated for its antimicrobial activities on several microorganisms including bacteria, yeast, dermatophytic fungi & non-dermatophytic fungi.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.