Senna alata (Kasialata) : vertus médicinales en extraction alcoolique

Senna alata (Kasialata, Datié, cassia-alata, dartrier) — famille Fabacées.

Synonymes scientifiques : Cassia alata-L, Herpetica alata-(L)-Raf..

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 25 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 126 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Varghese GK (2013)

     Extrait The identity of the isolated compounds was established by spectroscopic analysis while their potential antidiabetic activity was assessed by in vitro enzyme inhibition studies. Discussion: One of the possible antidiabetic mechanisms of action of CA is by inhibiting carbohydrate digestion.

   • Selon Uwazie JN (2020)

     Extrait Animals in group A received distilled water while those in groups B-F were made diabetic by treatment with 150 mg/kg body weight (b.w.) of alloxan. Animals in Groups B-G were also made diabetic by alloxan treatment.

   • Selon Naowaboot J (2017)

     Extrait The present study investigated the effect of Senna alata leaf extracts on the regulation of abnormal glucose metabolism in HFD-induced obese mice. alata (250 & 500 mg/kg) significantly reduced hyperglycemia, hyperinsulinemia & hyperleptinemia.

   • Selon COLIN MN (2024)

     Extrait However, there has not been significant progress accomplished in terms of the evaluation of the dosage form so that test results for promising activities like antidiabetic, antifungal, & antiviral can be carried out into further research. Twenty pharmacological activities have been identified, with the flavonoid group (emodin, kaempferol, quercetin) as the most prevalent secondary metabolite found in Cassia alata.

   • Selon Kazeem MI (2015)

     Extrait Kazeem MI et al, Effect of Senna alata (L) Roxb (Fabaceae) Leaf Extracts on alpha-Amylase, alpha-Glucosidase & Postprandial Hyperglycemia in Rats, Trop J of Pharmaceut Res, 2015; 14(10):1843-8-http://dx.doi.org/10.4314/tjpr.v14i10.15,.

2. 2

   Cancer : traitement adjuvant du carcinome : colorectal

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Auteur (s.d.)

     Extrait Studies have found out that people in developed western countries are more prone to colorectal cancer due to their low fiber food habits & sedentary life-styles. In in-vivo studies, colorectal cancer was induced by administering Dimethyl hydrazine (DMH) intraperitoneally to male Wistar rats for 20 weeks.

   • Selon Onyegeme-Okerenta B (2018)

     Extrait Increases Cytotoxicity in the Human Breast, Prostate & Colorectal Cancer Cells, J of Cancer Treatment & Res, 2018; 6(3):44-53-. Onyegeme-Okerenta B et al, Ethyl Acetate Extract of Senna alata (L.) Roxb.

   • Selon Chahardehi AM (2021)

     Extrait In this study, we tested the extract & fractions on brine shrimp lethality test & antiproliferative activity on cancer & normal cell lines. The leaves of Senna alata from the Fabaceae family have been used in folk medicine for the cure of skin disease.

   • Selon Amir-Modarrhesi C (2021)

     Extrait In this study, we tested the extract & fractions on brine shrimp lethality test & antiproliferative activity on cancer & normal cell lines. The leaves of Senna alata from the Fabaceae family have been used in folk medicine for the cure of skin disease.

   • Selon Modamesr CA (2021)

     Extrait Methods: The 80 % ethanolic leaf extract & its fractions were examined for possible cytotoxic effect using sulforhodamine B (SRB) cytotoxicity assay towards breast cancer (MCF-7), normal (MCF10A) cell lines, & brine shrimp lethality test (BSLT). alata crude ethanolic leaf extract a& its fractions potentially contain significant bioactive compounds that are safe from adverse effects, which proves the therapeutic application of S.

3. 3

   Infection fongique : Candida albicans, Aspergillus niger, Penicillium notatum, Microsporum canis, Trichophyton mentagrophytes, Epidermophyton

   Partie usitée : Feuille. Profil pharmacologique documenté : Ketoconazole-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon SY T (2012)

     Extrait The minimum inhibitory concentration of the water leaf extract of C alata for Candida albicans, Aspergillus niger, Penicillium notatum, Microsporium canis & Trichophyton mentagrophytes were 26.90 mg, 32.40 mg, 29.50 mg, 30.30 mg and 27.80 mg respectively, while that of ethanol leaf extract of C alata for Candida albicans, Aspergillus niger, Penicillium notatum, Microsporum canis & Trichophyton mentagrophytes were 5.60 mg, 3.50 mg, 4.90 mg, 12.60 mg & 9.80 mg respectively. The extracts inhibited the growth of Candida albicans, Microsporum canis & Trichophyton mentagrophytes better than the Ketoconazole 200 mg used as a positive control (p<0.05).

   • Selon Alalor CA (2012)

     Extrait The assessment of antifungal potential of the aqueous & methanol extracts of sun-dried leaves of Cassia alata was investigated by testing the extracts against some fungi (Candida albicans, Trichophyton mentagrophyte, Aspergillus niger & Penicillium) using the Agar cup plate method. The results showed that the plant part can be used to treat infections caused by fungi (Candida albicans, Trichophyton mentagrophyte & Aspergillus niger) which were susceptible.

   • Selon Sule WF (2010)

     Extrait The results obtained showed that the leaf exudates and the ethanol extract of the leaf of S alata exhil: had marked antifungal effects on Microsporum canis, Trichophyton jirrucosum, Trichophyton mentagrophytes & Epidermophyton jlorrcosum. The test was conducted on Dermatophytes which included Dermatophytes of the genera Trichophyton, Microsporum & Epidermophyton.

   • Selon Somchit MN (2003)

     Extrait Crude ethanol & water extract of leaves & barks from Cassia alata were tested in vitro against fungi, (Aspergillus fumigatus & Microsporum canis), yeast (Candida albicans) & bacteria (Staphylococcus aureus & Escherichia coli). albicans showed concentration-dependent susceptibility towards both the ethanol & water extracts from the barks, but resistant towards the extracts of leaves.

   • Selon Ibrahim D (1995)

     Extrait mentagorophytes, Trichophyton rubrum & Microsporum gypseum had the MIC of 125 mg/ml, whereas Microsporum canis had the MIC of 62.5 mg/ml. Ethanolic extract of Cassia alata leaves was investigated for its antimicrobial activities on several microorganisms including bacteria, yeast, dermatophytic fungi & non-dermatophytic fungi.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.