Senna obtusifolia (Soumatjé bata) : medicinal properties in alcoholic extraction

Senna obtusifolia (Soumatjé bata, Kaka-bétjé-bata, Zépiant, Séné, Sou-marqué batârd, caca-à-béké batârd, stinking weed, herbe puante) — family Fabacée.

Scientific synonyms : Cassia obtusifolia L, Senna tora var. obtusifolia (L.) X.Y. Zhu, Emelista obtusifolia (L.) Raf., Cassia tora var. obtusifolia (L.) Haines.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 34 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: hepatitis, fatty liver, cirrhosis

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shihab S (2017)

     Excerpt The aim of the present study to evaluate the hepatoprotective effect of S Obtusifolia seeds extract against carbon tetrachloride CCL4 induced liver damage. Generally, the results suggest that S Obtusifolia seeds acts as potent hepatoprotective agent against CCL4 induced hepatotoxicity in rats.

   • According to Paudel P (2018)

     Excerpt The protective effects of the anthraquinone & naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway. seed is one of the most popular traditional Chinese medicine for mutagenicity, genotoxicity, hepatotoxicity, & acute inflammatory diseases.

   • According to Ali (2021)

     Excerpt CO & possesses a wide range of pharmacological properties (e.g., antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, & neuroprotective properties) a&may be used to treat Alzheimer's disease, Parkinson's disease, & cancer. Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, & natural remedy for treating headache, dizziness, constipation, tophobia, & lacrimation a&for improving eyesight.

   • According to Jung HA (2016)

     Excerpt Semen Cassiae has been traditionally used as an herbal remedy for liver, eye, & acute inflammatory diseases. All Cassiae semen constituents exhibited potent inhibitory activities against AChE & BACE1 with IC50 values of 6.29-109µg/mL & 0.94-190µg/mL, whereas Alaternin, questin, & Toralactone gentiobioside exhibited significant inhibitory activities against BChE with IC50 values of 113.10-137.74µg/mL.

   • According to Shrestha S (2017)

     Excerpt Cassia obtusifolia have been used to improve vision, inflammatory diseases, & as hepatoprotective agents & to promote urination from ancient times. obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside (5), & rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shihab S (2017)

     Excerpt The aim of the present study to evaluate the hepatoprotective effect of S Obtusifolia seeds extract against carbon tetrachloride CCL4 induced liver damage. Generally, the results suggest that S Obtusifolia seeds acts as potent hepatoprotective agent against CCL4 induced hepatotoxicity in rats.

   • According to Paudel P (2018)

     Excerpt The protective effects of the anthraquinone & naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway. seed is one of the most popular traditional Chinese medicine for mutagenicity, genotoxicity, hepatotoxicity, & acute inflammatory diseases.

   • According to Ali (2021)

     Excerpt CO & possesses a wide range of pharmacological properties (e.g., antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, & neuroprotective properties) a&may be used to treat Alzheimer's disease, Parkinson's disease, & cancer. Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, & natural remedy for treating headache, dizziness, constipation, tophobia, & lacrimation a&for improving eyesight.

   • According to Jung HA (2016)

     Excerpt obtusifolia & its constituents against acetylcholinesterase (AChE), butyrilcholinesterase (BChE), & β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) enzyme activity. obtusifolia seeds, was reported to have memory enhancing properties & anti-AD activity to ameliorate amyloid β-induced synaptic dysfunction.

   • According to Shrestha S (2017)

     Excerpt Cassia obtusifolia have been used to improve vision, inflammatory diseases, & as hepatoprotective agents & to promote urination from ancient times. obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside (5), & rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1.

3. 3

   Neurological disorders: transient ischaemic attack (TIA)

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KIM DH (2009)

     Excerpt The aim of this study was to determine the mechanism underlying the neuroprotective effects of the ethanolic extract of the seeds of Cassia obtusifolia (COE) (10 or 50mg/kg/day, p.o) on transient cerebral global ischemia induced by bilateral common carotid artery occlusion (2VO) in mice.

   • According to KIM DH (2007)

     Excerpt In the present study, we assessed the effect of the ethanolic extract of the seeds of Cassia obtusifolia (COE) on the learning and memory impairments induced by scopolamine or transient bilateral common carotid artery occlusion (2VO).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.