Senna obtusifolia (Soumatjé bata) : medicinal properties in alcoholic extraction

Senna obtusifolia (Soumatjé bata, Kaka-bétjé-bata, Zépiant, Séné, Sou-marqué batârd, caca-à-béké batârd, stinking weed, herbe puante) — family Fabacée.

Scientific synonyms : Cassia obtusifolia L, Senna tora var. obtusifolia (L.) X.Y. Zhu, Emelista obtusifolia (L.) Raf., Cassia tora var. obtusifolia (L.) Haines.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 35 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: abnormal serum levels of: ALT, AST, MDA, GSH, SOD, GPx, etc.

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shihab S (2017)

     Excerpt The aim of the present study to evaluate the hepatoprotective effect of S Obtusifolia seeds extract against carbon tetrachloride CCL4 induced liver damage. Generally, the results suggest that S Obtusifolia seeds acts as potent hepatoprotective agent against CCL4 induced hepatotoxicity in rats.

   • According to Ali (2021)

     Excerpt CO & possesses a wide range of pharmacological properties (e.g., antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, & neuroprotective properties) a&may be used to treat Alzheimer's disease, Parkinson's disease, & cancer. Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, & natural remedy for treating headache, dizziness, constipation, tophobia, & lacrimation a&for improving eyesight.

   • According to Jung HA (2016)

     Excerpt Semen Cassiae has been traditionally used as an herbal remedy for liver, eye, & acute inflammatory diseases. All Cassiae semen constituents exhibited potent inhibitory activities against AChE & BACE1 with IC50 values of 6.29-109µg/mL & 0.94-190µg/mL, whereas Alaternin, questin, & Toralactone gentiobioside exhibited significant inhibitory activities against BChE with IC50 values of 113.10-137.74µg/mL.

   • According to Shrestha S (2017)

     Excerpt Cassia obtusifolia have been used to improve vision, inflammatory diseases, & as hepatoprotective agents & to promote urination from ancient times. obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside (5), & rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1.

   • According to Seo Y (2017)

     Excerpt Immunoblotting & real-time polymerase chain reaction analyses revealed that the hepatoprotective effects were exerted through nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent antioxidative signaling. Together, these results provide insights into the effects of this medicinal plant as well as a basis for developing hepatoprotective agents as pharmaceuticals and/or nutraceuticals.

2. 2

   Hepatitis, cirrhosis, fatty liver

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shihab S (2017)

     Excerpt The aim of the present study to evaluate the hepatoprotective effect of S Obtusifolia seeds extract against carbon tetrachloride CCL4 induced liver damage. Generally, the results suggest that S Obtusifolia seeds acts as potent hepatoprotective agent against CCL4 induced hepatotoxicity in rats.

   • According to Ali (2021)

     Excerpt CO & possesses a wide range of pharmacological properties (e.g., antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, & neuroprotective properties) a&may be used to treat Alzheimer's disease, Parkinson's disease, & cancer. Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, & natural remedy for treating headache, dizziness, constipation, tophobia, & lacrimation a&for improving eyesight.

   • According to Jung HA (2016)

     Excerpt obtusifolia & its constituents against acetylcholinesterase (AChE), butyrilcholinesterase (BChE), & β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) enzyme activity. obtusifolia seeds, was reported to have memory enhancing properties & anti-AD activity to ameliorate amyloid β-induced synaptic dysfunction.

   • According to Shrestha S (2017)

     Excerpt Cassia obtusifolia have been used to improve vision, inflammatory diseases, & as hepatoprotective agents & to promote urination from ancient times. obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside (5), & rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1.

   • According to Seo Y (2017)

     Excerpt Immunoblotting & real-time polymerase chain reaction analyses revealed that the hepatoprotective effects were exerted through nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent antioxidative signaling. Together, these results provide insights into the effects of this medicinal plant as well as a basis for developing hepatoprotective agents as pharmaceuticals and/or nutraceuticals.

3. 3

   Neurological disorders: Alzheimer’s disease

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jung HA (2016)

     Excerpt Recent pharmacological reports have indicated that Cassiae semen has neuroprotective effects, attributable to its anti-inflammatory actions, in ischemic stroke & Alzheimer's disease (AD) models. All Cassiae semen constituents exhibited potent inhibitory activities against AChE & BACE1 with IC50 values of 6.29-109µg/mL & 0.94-190µg/mL, whereas Alaternin, questin, & Toralactone gentiobioside exhibited significant inhibitory activities against BChE with IC50 values of 113.10-137.74µg/mL.

   • According to Drever BD (2008)

     Excerpt The seeds of Cassia obtusifolia have long been used in traditional Eastern medicine & more recently the ethanolic fraction of the seeds (COE) has been shown to attenuate memory impairments in mice. The precise causative factors in neurodegenerative diseases such as Alzheimer’s (AD) & Parkinson’s disease remain élusive, but mechanisms implicated comprise excitotoxicity, mitochondrial dysfunction, & in the case of AD, the amyloïd beta peptide (Aβ).

   • According to Shrestha S (2017)

     Excerpt obtusifolia & structure-activity relationships (SARs) with respect to the inhibition of acetylcholinesterase (AChE), butyrilcholinesterase (BChE), & β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), which are related to Alzheimer's disease (AD). obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside (5), & rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1.

   • According to Obulesu M (2011)

     Excerpt These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtusifolia (Sickle pod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), & Salvia officinalis (Garden sage). Alzheimer’s disease (AD) is a devastative neurodegenerative disorder which needs adéquate studies on effective treatment options.

   • According to Ali (2021)

     Excerpt CO & possesses a wide range of pharmacological properties (e.g., antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, & neuroprotective properties) a&may be used to treat Alzheimer's disease, Parkinson's disease, & cancer. Cassia obtusifolia L., of the Leguminosae family, is used as a diuretic, laxative, tonic, purgative, & natural remedy for treating headache, dizziness, constipation, tophobia, & lacrimation a&for improving eyesight.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.