Senna occidentalis (Mocha coffee) : medicinal properties in alcoholic extraction

Senna occidentalis (Mocha coffee, Zèb-piant, stinking herb, Kafé-moka, Café de Moka, herbe puante) — family Fabacées.

Scientific synonyms : Cassia ciliata-Raf, C occidentalis-L.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 28 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 140 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders caused by alcoholism: abnormal serum parameters: cholesterol, total serum, ALP, ALT, etc.

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jafri M (1999)

     Excerpt The hepatoprotective effect of aqueous-ethanolic extract (50%, v/v) of leaves of Kasondi was studied on rat liver damage induced by paracetamol & ethyl alcohol by monitoring serum transaminase (aspartate amino transferase & serum alanine amino transferase), alkaline phosphatase, serum cholesterol, serum total lipids & histopathological alterations. (Caesalpiniaceae), commonly known as 'Kasondi', is used in Unani medicine for liver ailments and is an important ingredient of several polyherbal formulations marketed for liver diseases.

   • According to Nde AL (2022)

     Excerpt Senna occidentalis (L.) Link is a plant that has been used in medicine in some African countries, Asia and America. Several parts of this plant are used for preventing or treating diabetes, haematuria, rheumatism, typhoid, asthma, hepatotoxicity, disorders of haemoglobin & leprosy.

   • According to Haraguchi M (2003)

     Excerpt No significant differences in the biochemical parameters in the serum were found between the control and experimental chicks, but animals treated with 0.5% So in groups FP & TL, gained less weight and chicks that received 0.3% So or 0.5% So in the ration throughout life (TL) had a larger feed conversion ratio. The effects of 0.5%, 0.3% & 0.1% w/w concentrations of Senna occidentalis seed mixed with commercial ration were studied in 18 groups of 32 broiler chicks each, from 1 day to 49 days of age.

   • According to Mercer HD (1967)

     Excerpt Of 5 Holstein-Friesian & 3 Brown Swiss male calves from 7 to 20 months old & of weight from 155 to 620 lb, 5 had rumen fistulae and were given dried ground stems, leaves & beans of Cassia occidentalis into the rumen. There were extensive myodegeneretaion particularly on the hind limbs, some signs of liver necrosis & hemorrhagic kidney.

   • According to Sastry AV (2011)

     Excerpt The hepatoprotective effect of aqueous extract of seeds of C occidentalis was studied on rat liver damage induced by paracetamol and by monitoring SGPT, SGOT, alkaline phosphate, total bilirubin, & histopathological alterations. Cassia occidentalis, commonly known as ‘Coffee Senna’, is used in Unani medicine for liver ailments & is an important ingredient of several polyherbal formulations marketed for liver diseases.

2. 2

   Hepatitis, fatty liver, cirrhosis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nde AL (2022)

     Excerpt Senna occidentalis (L.) Link is a plant that has been used in medicine in some African countries, Asia and America. Several parts of this plant are used for preventing or treating diabetes, haematuria, rheumatism, typhoid, asthma, hepatotoxicity, disorders of haemoglobin & leprosy.

   • According to Jafri M (1999)

     Excerpt The hepatoprotective effect of aqueous-ethanolic extract (50%, v/v) of leaves of Kasondi was studied on rat liver damage induced by paracetamol & ethyl alcohol by monitoring serum transaminase (aspartate amino transferase & serum alanine amino transferase), alkaline phosphatase, serum cholesterol, serum total lipids & histopathological alterations. (Caesalpiniaceae), commonly known as 'Kasondi', is used in Unani medicine for liver ailments and is an important ingredient of several polyherbal formulations marketed for liver diseases.

   • According to Haraguchi M (2003)

     Excerpt The effects of 0.5%, 0.3% & 0.1% w/w concentrations of Senna occidentalis seed mixed with commercial ration were studied in 18 groups of 32 broiler chicks each, from 1 day to 49 days of age. Besides this, degenerative changes were found in the striated skeletal muscle in the chest, in the myocardium & in the liver in the animals that received the higher concentrations of seeds.

   • According to Sastry AV (2011)

     Excerpt The hepatoprotective effect of aqueous extract of seeds of C occidentalis was studied on rat liver damage induced by paracetamol and by monitoring SGPT, SGOT, alkaline phosphate, total bilirubin, & histopathological alterations. Cassia occidentalis, commonly known as ‘Coffee Senna’, is used in Unani medicine for liver ailments & is an important ingredient of several polyherbal formulations marketed for liver diseases.

   • According to Pranav I (2019)

     Excerpt We report an unusual case of an elderly woman who presented with a hepato-encephalopathic syndrome after ingestion of Senna occidentalis and elucidate the multi-system pathophysiology of this rapidly evolving disease. Clinical presentation mimics acute liver failure, which is very difficult to attribute to this seemingly innocuous agent.

3. 3

   Cancer: adjuvant treatment of breast and brain carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kamble SS (2019)

     Excerpt The methanolic extracts of Cassia occidentalis, Callistemon viminalis, Cleome viscosa & Mimosa hamata were assessed for their cytotoxic properties against a human breast cancer cell line MCF-7 by using the Sulforhodamine B (SRB) assay. Conclusion: The selected botanicals with their anti-angiogenic & antioxidant potential could be considered as natural resources in the identification of possible therapeutic agents for breast cancer.

   • According to Sayed A (2023)

     Excerpt These results suggest that the methanolic extract of CO is an excellent candidate with potential antiproliferative activity against lung cancer; however, further studies are necessary to clarify its mechanism of action. occidentalis on seven cancer cell lines, including A-549, Colo-205, Huh-7, HCT-116, PANC-1, SKOV-3, & BNL, demonstrated its selective potent cytotoxicity on lung cancer cells without affecting normal BNL cells.

   • According to Yadav JP (2010)

     Excerpt Cassia occidentalis is an annual or perennial Ayurvedic plant which is used in several traditional medicines to cure various diseases.

   • According to Bhagat (2010)

     Excerpt to evaluate the in vitro cytotoxicity & antibacterial properties of Cassia occidentalis (whole plant) via alcoholic, hydro-alcoholic, & aqueous extracts against eight human cancer cell lines from six different tissues & four bacterial strains. Results: It was observed that aqueous extract of CO (whole plant) had more potential than hydro-alcoholic & alcoholic extracts against HCT-15, SW-620, PC-3, MCF-7, SiHa, & OVCAR-5 human cancer cell lines at 100, 30, & 10 µg/ml in a dose-dependent manner.

   • According to Calderon AI (2006)

     Excerpt The SRB cytotoxicity assay was used to screen plant extracts, in a collaborative multinational OAS project involving Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua & Panama, against breast (MCF-7), lung (H-460), & central nervous system (SF-268) human cancer cell lines. The most active plants were Thevetia ahouai, Physalis viscosa, Piper jacquemontianum, Piper barbatum, Senna occidentalis, Tovomita longifolia, & Lippia cardiostegia.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.