Sesamum indicum (Jijiri) : medicinal properties in alcoholic extraction

Sesamum indicum (Jijiri, Sesame, Sésame) — family Pédialacées.

Scientific synonyms : Sesamum africanum-Tod, S orientalis-(L-)-Kuntze.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 104 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bhuvaneswari P (2012)

     Excerpt The aim of the present study was to evaluate the effect of ethanolic extract of Sesamum indicum on kidney function in Streptozotocin Nicotinamide induced diabetic rats. The above results shows that the ethanolic extract of S indicum seeds has a potential effect to control hyperglycemia in streptozotocin induced diabetic rats,.

   • According to Sadat Ghoreishi A (2016)

     Excerpt Materials & Methods: This clinical trial has been carried out on 60 type 2 diabetic patients who were randomly divided into two groups of 30 sesame seeds consumers (case) & 30 non sesame seeds consumers (control).The case group was given 60 grams sesame seeds per day for 2 months and the control group did not receive any sesame seeds. Due to the increased risk of the disease and its related complications, in addition to the harmless properties of sesame seeds, this research was aimed to study the effect of consuming sesame seeds on some biochemical factors in type 2 diabetic patients.

   • According to Rusmarilin H (2019)

     Excerpt This study was conducted to determine the bioactive components in food ingredients that have as potential natural antioxidants source, it can be used as an alternative to reduce degenerative diabetes mellitus.

   • According to Mirmiran P (2013)

     Excerpt The aim of this study was to investigate the effects of Ardeh, paste of ground unhulled sesame seeds, on lipid Methods: LDL/HDL-C ratio were determined at baseline & six weeks later. Results: - creases in serum TC, LDL-C, & other atherogenic lipid parameters and a mild increase in HDL-C also were observed during Ardeh supplementation.

   • According to Rahman E (2019)

     Excerpt Sesamum indicum has been extensively used in Bangladesh & other Indian Subcontinent as medication for various diseases including CNS disorders. It was found to have antioxidant, antitumor, antihypertensive, neuroprotective, hypoglycemic, antimicrobial, anticonvulsant and wound healing activity.

2. 2

   Cancer: adjuvant treatment for laryngeal squamous cell carcinoma and rhabdomyosarcoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SHAWKAT (2018)

     Excerpt The present study was conducted to investigate the active constituents found in ethanolic extract of Sesamum indicum defatted seeds & it’s cytotoxic activity on three types of cancer cell lines (Hep-2, AMN-3, & RD) & one normal embryo rat cell line (Ref). A clear cytotoxic activity was observed after 72 hr at concentration( 1000 µg/ml) which reached (85.83%, 40.06%, &20.20%) in the cell lines respectively, while the percentage of inhibition during exposure time of 48 hrs recorded 31.03% at a concentration of 1000µg/ml for RD cells.

   • According to Majdalawief AF (2020)

     Excerpt to evaluate the potential immunomodulatory effect of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation, Th1/Th2 balance, macrophage function, and the cytotoxic activity of natural killer (NK) cells. Constituents of S indicum may be used as effective therapeutic agents in regulating immune reactions implicated in various infectious & non- infectious conditions including cancer.

   • According to Liu Z (2006)

     Excerpt Some plant lignans can be converted by intestinal microbiota to the mammalian lignans, enterodiol and enterolactone, which may have protective effects against hormone-related diseases such as breast cancer.

   • According to Ghani NA (2011)

     Excerpt Results of in vitro growth inhibition (GI) of sesame extract against Human larynx epidermoid carcinoma (Hep-2), Ahmed- Mohammed- Nahi-2003 (AMN-3), Rhabdomyosarcoma (RD), & normal embryo rat (Ref) cell lines demonstrated that the growth of these cells significantly decreased when compared with control cultures (untreated), & the effects were dose, as well as, time- dependent for each Hep-2, AMN-3, & Ref cells. The present study was conducted to investigate the active constituents found in ethanolic extract of Sesamum indicum defatted seeds, & studies it effects on the serum levels of lipid & cytogenetic changes in bone marrow cells in laboratory mice (in vivo).

   • According to Kim S (2018)

     Excerpt Two human colon cancer cell lines were used in this study, HT29 colon adenocarcinoma cells & HCT116 colorectal carcinoma cells. Sesame (Sesamum indicum L.) leaves (SL) are used as vegetables & traditional medicines in Asian & African countries.

3. 3

   Bacterial infection: Klebsiella pneumoniae, Salmonella typhi, Escherichia coli and Staphylococcus aureus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ogunsola OK (2014)

     Excerpt Ethanol & aqueous leaf extracts were screened for anti-microbial activities on some pathogens: Klebsiella pneumonia, Salmonella typhii, Escherichia coli & Staphylococcus aureus using different concentrations (100mg/ml, 200mg/ml& 400mg/ml). Staphylococcus aureus growth was not inhibited or restricted from growing as the extract had no activity against the microorganism.

   • According to Shirmohammadi E (2014)

     Excerpt Shirmohammadi E et al, the antibacterial activity of silver nanoparticles produced in the plant Sesamum indicum seed extract, green method against multi-drug resistant Klebsiella pneumoniae, Euro J of Experimental Biology, 4(3):197-200, 2014,.

   • According to Raghavan Anilakumar K (2010)

     Excerpt Sesame (Sesamum indicum) seeds have been grown in tropical regions throughout the world since prehistoric times. Th e antibacterial activity of seeds against Staphylococcus & Streptococcus as well as common skin fungi, such as athlete’s foot fungus has also been well recognized.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.