Solanum americanum (Agouman) : medicinal properties in alcoholic extraction

Solanum americanum (Agouman, Zèb anmè, Bitter herb, Herbe-amère) — family Solanacées.

Scientific synonyms : Solanum curtipes Bitter, S depilatum Bitter, S adventitium Polgar, S amarantoides Dunal, S caribaeum Dunal, S curtipes Bitter.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 319 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of chronic myeloid and promyelocytic leukaemia, and liver and uterine cancer

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shi F (2019)

     Excerpt Both SN & solaoiacid showed strong downregulation of the fatty acid synthase-epidermal growth factor receptor & anti-non-small cell lung cancer effects, & thus will become a novel drug for the treatment of non-small cell lung cancer. Solanum nigrum, extracted with water at 4°C, shows strong cytotoxic activity & inhibits tumor growth in Lewis’s tumor bearing-mice in a dose-dependent manner.

   • According to Paul S (2017)

     Excerpt Mechanism of cell death inducing pathway of chloroform fraction of methanolic extract of Solanum nigrum were studied in a panel of cervical cancer cell line. Conclusion: From the study it can be concluded that fatty acid rich chloroform fraction of SN is capable of inducing apoptosis in cervical cancer cells, through ROS mediated DNA damage.

   • According to Huang DB. (2013)

     Excerpt et al, Clinical Study of Solanum nigrum Mixture on Quality of Life & Immune Function in Patients with Advanced Liver Cancer.

   • According to SWETTHA M (2022)

     Excerpt sorafenib against HCC were compared in vitro, using various liver cancer cell lines & in vivo, utilizing NOD.CB17-Prkdcscid/J mice bearing human HCC xenografts. Here, we show that higher concentrations of sorafenib induce severe toxicity, in Chang Liver, as well as in acute & chronic in vivo models, indicating that, apart from the superior therapeutic benefit over sorafenib, Utt-B is a pharmacologically safer molecule, & the drug-induced undesirable effects can, thus, be substantially alleviated in the context of HCC chemotherapy.

   • According to Yang MY (2010)

     Excerpt Our results revealed the antimigration & anti-invasion effects of both extracts derived from SN, which may act as a promising therapeutic agent for the treatment of hepatocellular carcinoma. (SN) has exhibited multiple biological effects such as anti-inflammation and antiproliferation.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahir KB (2013)

     Excerpt Results: Oral administration of SNE (100 & 250 mg/kg.) for 21 days to streptozotocin-induced diabetes rats significantly (p<0.05) decreased the levels of blood glucose & improved the levels of plasma insulin. Objectives: The ethanolic extract of fruits of SN (SNE) was investigated to evaluate the effects of on blood glucose concentration, lipid profile & renal function tests and their possible mechanism of action involved in these activities.

   • According to Azarkish F (2017)

     Excerpt In addition, SNE was more effective than insulin in controlling blood glucose. Results: SNE could decrease blood glucose level in diabetic rats.

   • According to Sohrabipour S (2013)

     Excerpt Material/Methods Animals were divided into 5 groups (n=10): 2 groups served as non-diabetic controls (NDC), & the other groups had diabetes induced with a single injection of streptozotocin (STZ). We designed this study to investigate the effect of the administration of oral doses of aqueous extract from SN fruit on plasma glucose, lipid profiles, and the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic and non-diabetic rats.

   • According to Sohrabipour S (2013)

     Excerpt Material & methods: Animals were divided into 5 groups (n=10): 2 groups served as non-diabetic controls (NDC), & the other groups had diabetes induced with a single injection of streptozotocin (STZ). We designed this study to investigate the effect of the administration of oral doses of aqueous extract from SN fruit on plasma glucose, lipid profiles, & the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic & non-diabetic rats.

   • According to Dasgupta N (2013)

     Excerpt Dasgupta N et al, In-vitro & in-vivo studies of antidiabetic activity of Solanum nigrum leaves.

3. 3

   Liver disorders: normalisation of serum parameters: creatinine, GSH, bilirubin, etc.

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Alam A (2022)

     Excerpt The present study aimed to evaluate the role of bioactive components in Solanum nigrum fruit, its phytochemical screening, & in vivo antioxidant potential against liver injury. The SN fruit reduced the level of liver enzymes, & bilirubin.

   • According to Chester K (2019)

     Excerpt Materials & Methods: The aerial parts (leaves & berries) of Solanum nigrum were extracted with Hydroethanol-& polarity-based fractionations were performed. is well known for the management of different ailments including hepatic disorders.

   • According to Shi F (2019)

     Excerpt Solanum nigrum, extracted with water at 4°C, shows strong cytotoxic activity & inhibits tumor growth in Lewis’s tumor bearing-mice in a dose-dependent manner.

   • According to Raju K (2003)

     Excerpt Raju K et al, Effect of dried fruits of Solanum nigrum LINN against CCl4-induced hepatic damage in rats. M (2008) — excerpt: The results showed that the treatment of SNE significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, & total bilirubin), superoxide & hydroxyl radical. Therefore, the results of this study suggest that SNE could protect liver against the CCl4-induced oxidative damage in rats, & this hepatoprotective effect might be contributed to its modulation on detoxification enzymes & its antioxidant & free radical scavenger effects.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.