Solanum nigrum (Brèd-morèl) : medicinal properties in alcoholic extraction

Solanum nigrum (Brèd-morèl, Morèl-nwè, Brède morelle, Black nightshade, Morelle noire) — family Solanacées.

Scientific synonyms : Solanum triangulare-Lam.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 97 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for liver and uterine carcinoma

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Moglad EO (2019)

     Excerpt The objective of this study was to evaluate the cytotoxic, apoptotic, & cell cycle effect of four fractions obtained from the whole aerial part of Solanum nigrum, against three cancer cell lines (MCF-7, A2780, & HT29) & one normal cell line (MRC-5). Conclusion: The ethyl acetate fraction from SN strongly inhibited the growth of breast, ovarian, & colon cancer cell lines, & it was three folds selective against the normal fibroblasts.

   • According to Nawaz A (2022)

     Excerpt Hepatic carcinoma cell line (HepG2), cervical cancer cell line (HeLa) & baby hamster kidney (BHK) used as normal non-cancerous cells were evaluated for cytotoxicity against isolated fractions. The results demonstrated that S.N fractions exhibited anticancer activity against hepatic & cervical cancer cell lines with non-toxic effect in normal cells.

   • According to Raju K (2003)

     Excerpt Ethanol extract of Solanum nigrum LINN was investigated for its hepatoprotective activity against CCl4-induced hepatic damage in rats. The ethanol extract showed remarkable hepatoprotective activity.

   • According to Elhag RAM (2011)

     Excerpt The hepatoprotective effects of Solanum nigrum water & methanolic extracts were studied in rats injected with 0.2 ml/kg carbon tetrachloride (CCl4) for 10 consecutive days. The water extracts showed a hepatoprotective effect against CCl4- induced liver damage, which was evident by the decrease in serum aspartate amino transferase (AST), alanine amino transferase (ALT) & alkaline phosphates (ALP) activities bilirubin concentration & by mild histopathological lesions when compared with the group of rats injected with CCl4 alone.

   • According to Liu FP (2016)

     Excerpt nigrum aqueous extracts (150 mg/kg) with ethanol showed marked attenuation of ethanol-induced hepatotoxicity, as evidenced by significant reductions of serum transaminases (p < 0.01), and variation of hepatic oxidative indices (p < 0.05) and GSTA1 (p < 0.05), compared with the model group & mice that received S.N aqueous extracts (200 mg/kg). Conclusion: These results suggested that SN has hepatoprotective effects against ethanol-induced injury both in vitro and in vivo, & can protect the integrity of hepatocytes & thus reduce the release of liver GSTA1, which contributes to improved liver detoxification.

2. 2

   Type II diabetes mellitus

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ali NS (2010)

     Excerpt This results into impaired glucose use, which is a characteristic feature of diabetes mellitus i.e., resultant hyperglycemia. Now a day, Diabetes mellitus has become a real problem of public health in developing countries.

   • According to Author (n.d.)

     Excerpt The invention further relates to the preparation method of the solanum nigrum extractive & the application with the SN extractive being the active components in the medicaments for preventing & curing diseases, such as tumor, diabetes, asthma, coronary heart disease, etc. The invention relates to a solanum nigrum extractive, the preparation method & the medicament application thereof, wherein, the total content of solancarpine, solamargine & solasurine is 80wt% to 99wt%; the content of solancarpine is 30wt% to 50wt%; the content of solamargine is 10wt% to 30wt%; & the content of solasurine is 30wt% to 50wt%.

   • According to Kasali A (2016)

     Excerpt Hypoglycemic & antidiabetic activities & acute toxicity of extracts from leaves of Solanum nigrum L., an edible plant used in the Eastern part of the Democratic Republic of the Congo against diabetes, were evaluated on guinea-pigs. For inducing experimental diabetes mellitus, Alloxan monohydrate was used in normal saline by subcutaneous administration & Glibenclamide was used as standard drug.

   • According to Meonah STS (2010)

     Excerpt Meonah STS et al, Pharmacognostical & hypoglycemic activity of different parts of Solanum nigrum.

3. 3

   Cirrhosis, hepatitis, fatty liver disease

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Raju K (2003)

     Excerpt Ethanol extract of Solanum nigrum LINN was investigated for its hepatoprotective activity against CCl4-induced hepatic damage in rats. The ethanol extract showed remarkable hepatoprotective activity.

   • According to Chester K (2017)

     Excerpt Solanum nigrum is traditionally used for the management of the various liver disorders. The n-butanol enriched fraction of SN berries was found to be the most potent hepatoprotective fraction against all other fractions as it showed significantly (p < 0.01) better in vitro anti-oxidant potential than other fractions.

   • According to Kuppuswamy R (2003)

     Excerpt Kuppuswamy R et al, Effect of dried fruits of Solanum nigrum LINN against CCl4- induced hepatic damage in rats.

   • According to Elhag RAM (2011)

     Excerpt The hepatoprotective effects of Solanum nigrum water & methanolic extracts were studied in rats injected with 0.2 ml/kg carbon tetrachloride (CCl4) for 10 consecutive days. The water extracts showed a hepatoprotective effect against CCl4- induced liver damage, which was evident by the decrease in serum aspartate amino transferase (AST), alanine amino transferase (ALT) & alkaline phosphates (ALP) activities bilirubin concentration & by mild histopathological lesions when compared with the group of rats injected with CCl4 alone.

   • According to Nawaz A (2022)

     Excerpt In the present study, six isolated fractions (ethyl acetate, petroleum ether, chloroform, n-butanol, ethanol & aqueous) from Solanum nigrum were evaluated for their cytotoxic effect on different cell lines. Hepatic carcinoma cell line (HepG2), cervical cancer cell line (HeLa) & baby hamster kidney (BHK) used as normal non-cancerous cells were evaluated for cytotoxicity against isolated fractions.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.