Solanum nigrum (Brèd-morèl) : vertus médicinales en extraction alcoolique

Solanum nigrum (Brèd-morèl, Morèl-nwè, Brède morelle, Morelle noire, Black nightshade) — famille Solanacées.

Synonymes scientifiques : Solanum triangulare-Lam.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 16 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 97 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique & utérin

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Moglad EO (2019)

     Extrait The objective of this study was to evaluate the cytotoxic, apoptotic, & cell cycle effect of four fractions obtained from the whole aerial part of Solanum nigrum, against three cancer cell lines (MCF-7, A2780, & HT29) & one normal cell line (MRC-5). Conclusion: The ethyl acetate fraction from SN strongly inhibited the growth of breast, ovarian, & colon cancer cell lines, & it was three folds selective against the normal fibroblasts.

   • Selon Nawaz A (2022)

     Extrait Hepatic carcinoma cell line (HepG2), cervical cancer cell line (HeLa) & baby hamster kidney (BHK) used as normal non-cancerous cells were evaluated for cytotoxicity against isolated fractions. The results demonstrated that S.N fractions exhibited anticancer activity against hepatic & cervical cancer cell lines with non-toxic effect in normal cells.

   • Selon Raju K (2003)

     Extrait Ethanol extract of Solanum nigrum LINN was investigated for its hepatoprotective activity against CCl4-induced hepatic damage in rats. The ethanol extract showed remarkable hepatoprotective activity.

   • Selon Elhag RAM (2011)

     Extrait The hepatoprotective effects of Solanum nigrum water & methanolic extracts were studied in rats injected with 0.2 ml/kg carbon tetrachloride (CCl4) for 10 consecutive days. The water extracts showed a hepatoprotective effect against CCl4- induced liver damage, which was evident by the decrease in serum aspartate amino transferase (AST), alanine amino transferase (ALT) & alkaline phosphates (ALP) activities bilirubin concentration & by mild histopathological lesions when compared with the group of rats injected with CCl4 alone.

   • Selon Liu FP (2016)

     Extrait nigrum aqueous extracts (150 mg/kg) with ethanol showed marked attenuation of ethanol-induced hepatotoxicity, as evidenced by significant reductions of serum transaminases (p < 0.01), and variation of hepatic oxidative indices (p < 0.05) and GSTA1 (p < 0.05), compared with the model group & mice that received S.N aqueous extracts (200 mg/kg). Conclusion: These results suggested that SN has hepatoprotective effects against ethanol-induced injury both in vitro and in vivo, & can protect the integrity of hepatocytes & thus reduce the release of liver GSTA1, which contributes to improved liver detoxification.

2. 2

   Diabète mellitus de type II

   Partie usitée : Parties aériennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ali NS (2010)

     Extrait This results into impaired glucose use, which is a characteristic feature of diabetes mellitus i.e., resultant hyperglycemia. Now a day, Diabetes mellitus has become a real problem of public health in developing countries.

   • Selon Auteur (s.d.)

     Extrait The invention further relates to the preparation method of the solanum nigrum extractive & the application with the SN extractive being the active components in the medicaments for preventing & curing diseases, such as tumor, diabetes, asthma, coronary heart disease, etc. The invention relates to a solanum nigrum extractive, the preparation method & the medicament application thereof, wherein, the total content of solancarpine, solamargine & solasurine is 80wt% to 99wt%; the content of solancarpine is 30wt% to 50wt%; the content of solamargine is 10wt% to 30wt%; & the content of solasurine is 30wt% to 50wt%.

   • Selon Kasali A (2016)

     Extrait Hypoglycemic & antidiabetic activities & acute toxicity of extracts from leaves of Solanum nigrum L., an edible plant used in the Eastern part of the Democratic Republic of the Congo against diabetes, were evaluated on guinea-pigs. For inducing experimental diabetes mellitus, Alloxan monohydrate was used in normal saline by subcutaneous administration & Glibenclamide was used as standard drug.

   • Selon Meonah STS (2010)

     Extrait Meonah STS et al, Pharmacognostical & hypoglycemic activity of different parts of Solanum nigrum.

3. 3

   Cirrhose, hépatite, stéatose hépatique

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Raju K (2003)

     Extrait Ethanol extract of Solanum nigrum LINN was investigated for its hepatoprotective activity against CCl4-induced hepatic damage in rats. The ethanol extract showed remarkable hepatoprotective activity.

   • Selon Chester K (2017)

     Extrait Solanum nigrum is traditionally used for the management of the various liver disorders. The n-butanol enriched fraction of SN berries was found to be the most potent hepatoprotective fraction against all other fractions as it showed significantly (p < 0.01) better in vitro anti-oxidant potential than other fractions.

   • Selon Kuppuswamy R (2003)

     Extrait Kuppuswamy R et al, Effect of dried fruits of Solanum nigrum LINN against CCl4- induced hepatic damage in rats.

   • Selon Elhag RAM (2011)

     Extrait The hepatoprotective effects of Solanum nigrum water & methanolic extracts were studied in rats injected with 0.2 ml/kg carbon tetrachloride (CCl4) for 10 consecutive days. The water extracts showed a hepatoprotective effect against CCl4- induced liver damage, which was evident by the decrease in serum aspartate amino transferase (AST), alanine amino transferase (ALT) & alkaline phosphates (ALP) activities bilirubin concentration & by mild histopathological lesions when compared with the group of rats injected with CCl4 alone.

   • Selon Nawaz A (2022)

     Extrait In the present study, six isolated fractions (ethyl acetate, petroleum ether, chloroform, n-butanol, ethanol & aqueous) from Solanum nigrum were evaluated for their cytotoxic effect on different cell lines. Hepatic carcinoma cell line (HepG2), cervical cancer cell line (HeLa) & baby hamster kidney (BHK) used as normal non-cancerous cells were evaluated for cytotoxicity against isolated fractions.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.