Stevia rebaudania (stevia) : medicinal properties in alcoholic extraction

Stevia rebaudania (stevia, èstévia, Stévia) — family Asteracées.

Scientific synonyms : Eupatorium rebaudianum-Bertoni.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 190 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Metabolic syndrome

   Plant part used: Sheet. Mentioned synergistic association: association synergique avec UNCARIA TOMENTOSA- (Willd ex Roem & Schult)-DC (Écorce de tige).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2017)

     Excerpt Further, both in vitro & in vivo studies indicate that these glycosides & the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, & anticancer. This work reviews the antiobesity, antihyperglycemic, antihypertensive, & antihyperlipidemic effects of the majority of glycosides & aqueous/ alcoholic extracts from the leaves, flowers, & roots of the SR.

   • According to MOMTAZI-BOROJENI AA (2017)

     Excerpt Beyond their value as sweeteners, Stevia & its glycosdies possess therapeutic effects against several diseases such as cancer, diabetes mellitus, hypertension, inflammation, cystic fibrosis, obesity & tooth decay. Stevia leaves contain steviol glycosides including stevioside, rebaudioside (A to F), steviolbioside, & isosteviol, which are responsible for the plant's sweet taste, & have commercial value all over the world as a sugar substitute in foods, beverages and medicines.

   • According to Villegas Vílchez LF (2022)

     Excerpt The objective of this in vivo study is to evaluate in five rat models the pharmacologic effects & toxicity of a commercial hydro-alcoholic extract, GlucoMedix®, derived from Stevia rebaudiana & the pentacyclic chemotype of Uncaria Tomentosa (Willd.) DC, for use as a treatment for metabolic syndrome. Daily oral doses of 250 - 1000 mg/kg were used to evaluate the treatment effects in hyperglycemic (alloxan-induced & Glibenclamide-controlled), hyperlipidemic (cholesterol-induced & Atorvastatin-controlled), & hypertensive (L-NAME-induced & Enalapril-controlled) rat models.

   • According to Arumugam B, (2020)

     Excerpt In addition to its hypoglycemic property, the plant also exhibits antibacterial, anti-inflammatory, hypotensive, antiseptic, diuretic, anti-fertility & cardiotonic properties. Diabetic & obese people with hyperglycemia who are in a condition to follow a strict diet can use stevioside as an alternative sweetener.

   • According to Pallares A (2015)

     Excerpt Full Length Research Article Recent randomized controlled trials have demonstrated the utility of stevioside and related compounds, extracted and refined from stevia leaf plant, to improve blood glucose and blood pressure in patients with type 2 diabetes. A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to PETRUS RISKY P (2017)

     Excerpt The optimal dose of ethanol extract of stevia leaf & ethanol extract of bitter leaf that can decrease LPO level in mouse Diabetes Mellitus induced is 75%: 25% STSA dose ie 75 mg / kg BW stevia: 5.12 mg / kg BB sambiloto. This study was conducted to determine the optimal effectiveness of ethanol extract combination of stevia leaves & bitter leaves of oxidative stress in diabetic Mellitus rats compared in single form.

   • According to Villegas Vílchez LF (2022)

     Excerpt Daily oral doses of 250 - 1000 mg/kg were used to evaluate the treatment effects in hyperglycemic (alloxan-induced & Glibenclamide-controlled), hyperlipidemic (cholesterol-induced & Atorvastatin-controlled), & hypertensive (L-NAME-induced & Enalapril-controlled) rat models. Alloxan-induced hyperglycemia was reduced in a dose-dependent manner within 28 days or less.

   • According to Jaitak V (2009)

     Excerpt They are widely used as natural sweeteners for diabetic patients, but the long extraction procedures required & the optimisation of product yield present challenging problems.

   • According to ABDI M (2023)

     Excerpt The current study aimed to investigate the effect of Stevia rebaudiana hydroalcoholic extract on serum testosterone levels, sperm parameters, in vitro fertilization (IVF) success, & in vitro embryonic developmental potential to reach the blastocyst stage in a streptozotocin (STZ)-induced mouse model of diabetes. In this research, 30 male mice were distributed randomly into control, diabetic (streptozotocin 150 mg/kg) & diabetic + Stevia (400 mg/kg) groups.

   • According to Shivanna N (2013)

     Excerpt Results: The results showed a reduction of blood glucose, ALT & AST, & increment of insulin level in the stevia whole leaves powder & extracted polyphenols fed rats compared to control diabetic group. Stevia rebaudiana has been used for the treatment of diabetes in, for example, Brazil, although a positive effect on antidiabetic & its complications has not been unequivocally demonstrated.

3. 3

   Cancer: adjuvant treatment for peritoneal carcinoma associated with ascites

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rojas E (2018)

     Excerpt Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. Populations: A growing body of evidence indicates that SR is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro.

   • According to Rajesh P (2010)

     Excerpt Anticancer activity of ethanolic extract of leaves of Stevia Rebaudiana was determined in the rat by induced Ehrlich’s Ascites carcinoma.

   • According to Author (2017)

     Excerpt Further, both in vitro & in vivo studies indicate that these glycosides & the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, & anticancer. These compounds can serve as a natural & alternative treatment for diseases that are associated with metabolic syndrome, thus contributing to health promotion.

   • According to TIWARI NK (2025)

     Excerpt were treated with different concentrations of methanolic extracts i.e., 1%, 3%, 5%, 7% & 10% (v/v) with a control set & the results suggested that Ocimum tenuiflorum had stronger antiproliferative potential than Stevia rebaudiana in all the doses. In the present study, we analysed various chemical components present in the methanolic leaf extracts of both of the plants employing chromatography (GC-MS) & assessed antiproliferative activity of different doses of methanolic leaf extracts in root apical meristems of Allium cepa L.

   • According to Peteliuk V (2021)

     Excerpt rebaudiana extract & its individual glycosides, including anti-hypertensive, anti-obesity, anti-diabetic, antioxidant, anti-cancer, anti-inflammatory, & antimicrobial effects & improvement of kidney function. Many studies have suggested the benefits of Stevia extract over sugar & artificial sweeteners, but it is still not a very popular sugar substitute.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.