Swietenia mahogani (Mahogani-ti-fèy) : medicinal properties in alcoholic extraction

Swietenia mahogani (Mahogani-ti-fèy, Small-leaved mahogany, Mahogany-à-petite-feuille) — family Méliacées.

Scientific synonyms : Cedrela Mahogani-L.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 47 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mahid Al-Hasan SMM (2011)

     Excerpt It was observed that the EESM (ethanolic extract of S Mahogani) seeds have Hypoglycaemic effect in Alloxan treated diabetic rats but has no effect on Blood glucose level in nondiabetic rats. The result suggested that the ethanolic extract of S Mahogani seeds may be a Useful in Hypoglycaemic agent in the treatment of diabetes mellitus.

   • According to Hasan SM (2013)

     Excerpt The study was performed to compare the blood glucose lowering effect of Swietenia mahagoni seeds with an oral antidiabetic drug, rosiglitazone in experimentally induced diabetic rats. The observations and results of the present study provide information that ethanolic extract of SM seeds has hypoglycaemic effect in experimentally induced diabetic rats which requires further investigation.

   • According to Debasis De (2011)

     Excerpt Antidiabetic, antioxidative, & antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni seed studied in streptozotocin-induced diabetic rats. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, & lipoproteins towards the control level in this experimental diabetic model.

   • According to SMMMA H (2013)

     Excerpt SMMMA H et al, Comparative study of the effect of ethanolic extract of Swietenia Mahogani seeds with Rosiglitazone on experimentally induced diabetes mellitus in rats, Bangladesh Med Res Council Bull 2013; 39: 6-10.-Abstract The study was performed to compare the blood glucose lowering effect of Swietenia Mahogani seeds with an oral antidiabetic drug, Rosiglitazone in experimentally induced diabetic rats. The observations and results of the present study provide information that ethanolic extract of S Mahogani seeds has Hypoglycaemic effect in experimentally induced diabetic rats which requires further investigation.

   • According to WRESDIYATI T (2015)

     Excerpt This ethanolic-maceration SM seed extract also showed hypoglycemic effects in hyperglycemic rats at dose from 100 to 500 mg/kgBW. The objectives of this study were to analyse & compare the bioactive compounds and α-glucosidase inhibitory effect of four different types of Swietenia Mahagoni seed extract, & to analyze the hypoglycemic activity of the greatest inhibition of α-glucosidase-extract in rats.

2. 2

   Fungal: Candida albicans, Cryptococcus neoformans

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shyam Sundar D (2013)

     Excerpt The antifungal activities of the extracts were tested against Cryptococcus neoformans & Candida albicans by disc diffusion assay & broth dilution method to determine minimum inhibitory concentration. The present study was carried out to evaluate the antifungal activities of aqueous & solvent extract of Swietenia Mahogany which is used as a traditional folk medicine in India for the treatment of different infectious diseases & disorders.

   • According to Al-alusi1 NT (n.d.)

     Excerpt This study has carried out to evaluate the antibacterial effect & the interaction between Tinospora crispa & Swietenia Mahogani extracts against resistant strains of Methicillin-resistant Staphylococcus aureus (MRSA). Mahogani extracts were assayed to determine their antibacterial activity against eight clinical MRSA isolates.

   • According to UDOUMOH AF (2011)

     Excerpt Different concentrations of ethanolic extracts of Swietenia Mahogani & Carapa procera leaves were evaluated for antibacterial activity against Staphylococcus aureus ATCC25923, Escherichia coli ATCC 25922, & Pseudomonas aeruginosa ATCC 27853 using the agar well diffusion method. It was concluded that the ethanolic leaf extracts of SM & CP have antibacterial & wound healing properties.

   • According to Sahgal G (n.d.)

     Excerpt Sahgal G et al, Phytochemical & antimicrobial activity of Swietenia Mahogani crude methanolic seed extract.

   • According to MADHUMITHA S (2016)

     Excerpt MADHUMITHA S et al, PHYTOCHEMICAL ANALYSIS & ANTIBACTERIAL ACTIVITY OF SWIETENIA MAHAGONI: A HIGHLY MEDICINAL PLANT IN INDIA, Asian J Pharm Clin Res, 9(6) :62-4, 2016,.

3. 3

   Acute diarrhoea

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hajra S (2012)

     Excerpt Mahogani seeds at the concentration (50, 100, 200 a&300 mg kg-1 b.wt., p.o) using different experimental model such as castor oïl induced diarrhea, enteropooling & gastrointestinal motility were determined by in vivo experimental models. The prolonged onset of diarrhoea, inhibition of castor oil-induced enteropooling & the suppressed propulsive movement observed in this study support the traditional claim of SMi as an antidiarrhoeal drug in the Indian system of medicine without any side effects.

   • According to Matin-Syed A (2013)

     Excerpt The present study was designed to investigate the total tannin content as secondary metabolite & to evaluate the microbiological contaminants & acute toxicity studies of ethanolic extract of Swietenia Mahagoni leaves.

   • According to NAVEEN Y P (2015)

     Excerpt the study evaluates the acute toxicity of the Swietenia Mahagoni leaf in rats of Wistar strain.

   • According to Sahgal G (2010)

     Excerpt Sahgal G et al, Brine shrimp lethality & acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.