Synedrela nodiflora (Fat pig) : medicinal properties in alcoholic extraction

Synedrela nodiflora (Fat pig, Man-Bôgn, Zèb-dépo, one-eyed lady, deposit grass, Kochon-gra, Cochon gras, madame borgne, herbe-à-dépôt) — family Asteracées.

Scientific synonyms : Verbesina nodiflorum-L, Ucacou nodiflorum-(L)-Hitch.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 30 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Normalisation of serum parameters: MDA, ALT, AST, bilirubin, SGOT, SGPT

   Plant part used: Shaft.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kabir T (2014)

     Excerpt Since result of biochemical studies of blood sample of carbon tetrachloride treated rats showed significant increase in the level of serum enzyme activities, reflecting the liver injury caused by CCL4 & blood sample from the animals treated with the ethanol extract of SN showed significant decrease in the level of serum marker, indicating the protection of hepatic cells, the extract of above plant could afford significant dose dependent protection against CCL4 induced hepatocellular injury,. It was found that the ethanol extract of SN at a dose of 250mg/kg body weight exhibited significant protective effect by lowering the serum level of alanine aminotransferase (ALT) or serum Glutamate Pyruvate Transferase (SGPT), & 100mg/kg body weight exhibited significant protective effect by lowering both the serum levels of alanine aminotransferase (ALT) or serum Glutamate Pyruvate Transferase (SGPT), aspartate aminotransferase (AST) or serum glutamate oxaloacetate transaminase (SGOT).

   • According to TASMIIATUL KABIR (2014)

     Excerpt Since result of biochemical studies of blood sample of carbon tetrachloride treated rats showed significant increase in the level of serum enzyme activities , reflecting the liver injury caused by CCL4 & blood sample from the animals treated with the ethanol extract of S nodiflora showed significant decrease in the level of serum marker , indicating the protection of hepatic cells , the extract of above plant could afford significant dose dependent protection against CCL4 induced hepatocellular injury. It was found that the ethanol extract of S nodiflora at a dose of 250mg/kg body weight exhibited significant protective effect by lowering the serum level of alanine aminotransferase(ALT) or serum Glutamate Pyruvate Transferase (SGPT), & 100mg/kg body weight exhibited significant protective effect by lowering both the serum levels of alanine aminotransferase (ALT) or serum Glutamate Pyruvate Transferase (SGPT),aspartate aminotransferase (AST) or serum glutamate oxaloacetate transaminase (SGOT).

   • According to Chaniad P (2021)

     Excerpt Moreover, no significant alterations in the biochemical parameters of liver & kidney function & no histological changes in the liver or kidney tissues were observed. Biochemical parameters of liver & kidney function & the histopathology of liver & kidney tissues of the acute toxicity group were then examined.

   • According to Iqbal M (2016)

     Excerpt Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), hepatic antioxidant enzymes, & malondialdehyde (MDA) levels were estimated. Biochemical, immunohistochemical, histological, & ultrastructural findings were in agreement to support the hepatoprotective effect of SN against CCl4-mediated oxidative hepatic damage.

   • According to Amoateng P (2016)

     Excerpt METHODS: The toxicological evaluation of the extract (100, 300 and 1000 mgkg-1) was focused on haematological, serum biochemical parameters and histopathological changes of some isolated organs. CONCLUSIONS: The findings suggest hydroethanolic extract of Synedrella nodiflora (L) Gaertn generally has a low toxicity profile following a 90-day continuous oral administration in male Sprague-Dawley rats under the present Laboratory conditions.

2. 2

   Arthritis, osteoarthritis, rheumatoid arthritis, rheumatism, oedema

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Forestieri AM (1996)

     Excerpt (leaves), Lippia nodiflora (L.) Michx (leaves) & Synedrella nodiflora (Whole plant), were evaluated in pharmacological tests using rats & mice. Antiinflammatory, analgesic & antipyretic activities and toxicity of different extracts (decoction, petroleum ether, ethanol & aqueous extracts) of T: Afrormosiu Laxiflorus (Benth.

   • According to Haque A (2012)

     Excerpt Haque A et al, Antiinflammatory & Insecticidal activities of Synedrella nodiflora, Molecular & Clin Pharm, 2012, 2(2), 60-7- Abstract Methanolic extract of the leaves of Synedrella nodiflora (Asteraceae) has been evaluated for its insecticidal & anti-inflammatory potential against the insect Sitophilus oryzae using surface film method & carrageenan & formalin induced paw edema in rat, respectively. The result suggest into the plant extract could be used as a potential insecticidal as well as potential anti-inflammatory agent.

   • According to Amoateng P (2011)

     Excerpt Conclusions: These findings suggest that hydroethanolic extract of Synedrella nodiflora contains antioxidant principles which may contribute to its traditional use in epilepsy management. The present study aimed at investigating the possible mechanisms of antioxidant effects of the hydroethanolic extract of the whole plant.

   • According to Oloyede G (2016)

     Excerpt Node weed Synedrella nodiflora used traditionally in Nigeria for treating various diseases such as arthritis, rheumatism, dropsy, swellings, oedema, gout and leprosy is one of such plant. The antioxidant properties of plants have been linked to their therapeutic & protective effects against diseases such as inflammation, arthritis, rheumatism, Parkins-on's disease, Alzheimer's disease, cancer, cardiovascular disorders, bacterial & viral infections.

   • According to LE TTK (2020)

     Excerpt nodiflora) has long been used for the treatment of inflammatory diseases, including liver disease, asthma, rheumatism & earache, in tropical countries throughout America, Asia & Africa. In the present study, the anti-inflammatory mechanism of a methanol extract of S.

3. 3

   Pain, hyperalgesia, allodynia: (Allodynia: pain triggered by a stimulus that is normally painless.)

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Amoateng P (2015)

     Excerpt The hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn whole plant has demonstrated analgesic effects in acute pain models. The present study illustrates an evaluation of the hydro-ethanolic extract of the plant for possible analgesic properties in hyperalgesia and allodynia associated with vincristine-induced neuropathy in rats.

   • According to Amoateng P (2017)

     Excerpt CONCLUSION: The hydroethanolic extract of the whole plant of Synedrella nodiflora possess analgesic effect in paclitaxel-induced. The hydroethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain.

   • According to Woode E (2009)

     Excerpt J of Pharm &Toxicol, 4: 17-29, 2009-This study presents the effect of an ethanolic extract of the whole plant of Synedrella nodiflora, a plant used in Ghana for the treatment of epilepsy & pain, in formalin-induced pain & acetic acid-induced writhing assay and the possible mode(s) of action of its analgesic action. Woode E et al, Antinociceptive Effects of an Ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn in Mice: Involvement of Adenosinergic Mechanisms.

   • According to Forestieri AM (1996)

     Excerpt (leaves), Lippia nodiflora (L.) Michx (leaves) & Synedrella nodiflora (Whole plant), were evaluated in pharmacological tests using rats & mice. Antiinflammatory, analgesic & antipyretic activities and toxicity of different extracts (decoction, petroleum ether, ethanol & aqueous extracts) of T: Afrormosiu Laxiflorus (Benth.

   • According to Nahar L (2012)

     Excerpt nodiflora (SN) was determined using Folin Ciocalteu reagent, phosphomolybdenum method, free radical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) & the reducing power activity. Analgesic activity was done by acetic acid & formalin model & CNS depressant activity was measured by the hole cross & open field method.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.