Synsepalum dulcificum (Miracle fruit) : medicinal properties in alcoholic extraction

Synsepalum dulcificum (Miracle fruit, Fruit-miracle) — family Sapotacées.

Scientific synonyms : Richadella dulcifica-.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 53 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Dioso MK (2016)

     Excerpt Twenty-five albino rats were induced with type 2 diabetes mellitus using alloxan and were grouped and treated into five treatments (positive control using metformin, 50% fruit extract, 50% leaf extract, 100% fruit extract, 100% leaf extract).Blood glucose level were analyzed and compared. The Hypoglycemic effects of its fruit & leaf extracts on the blood glucose level of alloxan-induced diabetic albino rats were determined & compared with the positive control using Metformin.

   • According to Olabisi OT (2019)

     Excerpt the present study aimed to provide insight into the antidiabetic mechanisms of methanol & flavonoid-rich leaf extracts of Synsepalum dulcificum (MSD and FSD, respectively). Conclusion: Results from this study indicate that increased insulin synthesis, reduction of inflammation & inhibition of carbohydrate metabolizing enzymes are likely mechanisms by which MSD &FSD exert antidiabetic action in type II diabetic rats.

   • According to -Chen CC (2006)

     Excerpt In an attempt to probe a new target to improve insulin resistance, miracle fruit (Synsepalum dulcificum) was employed to investigate the effect on insulin resistance induced by fructose-rich chow in rats. In conclusion, the results suggest that miracle fruit may be used as an adjuvant for treating diabetic patients with insulin resistance because this fruit has the ability to improve insulin sensitivity.

   • According to Swamy KB (2013)

     Excerpt Synsepalum dulcificum or the "miracle fruit" is well known for its taste-Modifying ability. The miracle fruit can be a healthy additive due to its unique characteristics, including sour taste sensation modification as well as its antioxidant & antidiabetic effects.

   • According to Haddad SG (2020)

     Excerpt Haddad SG et al, Antihyperglycemia & hepatoprotective properties of miracle fruit (Synsepalum dulcificum) compared to aspartame in alloxant induced diabetic mice J of Integrative Med, 8(6):514-21, 2020-DOI: https://doi.org/j.joim.2020.09.001,.

2. 2

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Swamy KB (2013)

     Excerpt Synsepalum dulcificum or the "miracle fruit" is well known for its taste-Modifying ability. This effect was shown to be related to a glycoprotein called "miraculin." Other beneficial characteristics of this fruit were its antioxidant & anticancer abilities that are due to the various amides existing in the miracle fruit.

   • According to LU S (2014)

     Excerpt The aim of this study was to determine the chemical composition of Synsepalum dulcificum leaf essential oil obtained by steam distillation. In addition, the antitumoral activity using MTT assay of the leaf essential oil exhibited this oil was effective against human K562 cancer cell line in a dose dependent manner.

   • According to Author (2013)

     Excerpt The Synsepalum dulcificum leaf total flavonoid was determined & the Technology & conditions was to be optimum by using the response surface method on the basis of single factor experiment. The Synsepalum dulcificum leaf can improve heart Burn, indigestion, poor appetite and other symptoms, such as atherosclerosis, high blood pressure & diabetes.

   • According to Seong J (2018)

     Excerpt dulcificum) Daniell (Sapotaceae) on human colon cancer (HCT-116 & HT-29), human monocytic leukemia (THP-1) & normal (HDFn) cell lines, & its effect on the expression of early apoptotic genes, c-fos & c-jun. dulcificum on HCT-116 & HT-29 colon cancer cells is due to the induced apoptosis which is caused by the up-regulation of the expression of early apoptotic genes, c-fos & c-jun.

   • According to Author (2016)

     Excerpt The results obtained indicate that the root extracts has potent cytotoxic activity toward human colon cancer cells (HCT116). Selected fractions were evaluated for their in vitro anticancer & the crude extract for its antioxidant activity.

3. 3

   Listeriosis: Listeria monocytogenes

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to LU S (2014)

     Excerpt The result of the antimicrobial assay showed that the essential oil displayed varying degrees of antibacterial activity against all tested bacterial except for Pseudomonas aeruginosa, along with minimum inhibition concentration(MIC)values from 39.06 to 252.15 mg/L. The aim of this study was to determine the chemical composition of Synsepalum dulcificum leaf essential oil obtained by steam distillation.

   • According to Lateef A (2016)

     Excerpt Lateef A et al, Phytosynthesis of silver nanoparticles (AgNPs) using miracle fruit plant (Synsepalum dulcificum) for antimicrobial, catalytic, anticoagulant, & thrombolytic applications, DOI: https:/doi.org/10.1515/ntrev-2016-0039,.

   • According to Afzam Ibrahim H (n.d.)

     Excerpt Afzam Ibrahim H et al, Antibacterial Property of Synsepalum dulcificum Leaves Aqueous Extract against Oral Pathogens & Its Chemical Compounds, Archives of Orofacial Sci, 020; 15(1): 55-64,.

   • According to Author (2013)

     Excerpt The chemical composition of S dulcificum leaf essential oil obtained by steam distillation was determined & characterized the in vitro antibacterial activity & antitumoral activity of this essential oil. The Synsepalum dulcificum leaf total flavonoid was determined & the Technology & conditions was to be optimum by using the response surface method on the basis of single factor experiment.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.