Syzygium malacense (Ponm Tayiti) : medicinal properties in alcoholic extraction

Syzygium malacense (Ponm Tayiti, Ponm-dlo, Ponm makak) — family Myrtacées.

Scientific synonyms : CaryEugenia malaccensis L, Jambosa malaccensis (L.) DC, Myrtus malaccensis (L.) Spreng, Eugenia domestica Baill, E macrophylla Lam, E pseudomalaccensis Linden, E purpurascens Baill., E purpurea Roxb, Jambosa domestica DC, J laevis Montrouz, J macrophylla (Lam.) DC, J purpurascens DC, J purpurea (Roxb.) Wight & Arn, Myrtus lamarckii F.Dietr, M macrophylla (Lam.) Spreng, Syzygium laevelaeve (Montrouz.) Govaerts.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 73 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to OLDONI TLC (2025)

     Excerpt This study investigated the antihyperglycemic potential of a hydroalcoholic extract from Syzygium malaccense leaves (E-SM) & isolate phenolic compounds with antioxidant & cytotoxic activities through a bioguided assay. In diabetic rats treated with E-SM (400 mg/kg), kidney tissue showed restored catalase activity similar to the control group, with consistent NPSH levels.

   • According to Arumugam B (2014)

     Excerpt The presence of the potent antioxidant & antihyperglycemic agent myricitrin in the SM leaf extract indicates the potential use of the extract in the management of diabetes mellitus & its related complications. The present study was designed to identify the ability of the leaf extract from Syzygium malaccense (L.) Merr.

   • According to Batista AG (2020)

     Excerpt In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) & investigated proofs of peripheral insulin resistance, hippocampal AKT–GSK3-β–tau activation, learning /memory performance, & brain frontal lobe oxidative stress. The intake of HS did not prevent weight gain but promoted peripheral insulin sensitivity, improved AKT signaling in the hippocampus, which prevented the activation of GSK3-β & lowered tau phosphorylation induced in HF.

   • According to Giovanna BA (2020)

     Excerpt In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) & investigated proofs of peripheral insulin resistance, hippocampal AKT-GSK3-beta-tau activation, learning/memory performance, & brain frontal lobe oxidative stress. The intake of HS did not prevent weight gain but promoted peripheral insulin sensitivity, improved AKT signaling in the hippocampus, which prevented the activation of GSK3-beta & lowered tau phosphorylation induced in HF.

   • According to Bairy KL (2005)

     Excerpt Methods: The aqueous & alcoholic extracts were compared with glibenclamide for their influence on fasting blood sugar, lipid profile & liver glycogen in both normoglycemic & to streptozotocin induced (50mg/kg ip) hyperglycemic rats. Conclusion: The extracts of SM with their beneficial effects on blood sugar and hyperlipidemia associated with diabetes could serve as good adjuvant to other oral hypoglycemic agents,.

2. 2

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2022)

     Excerpt MA had a low-key effect on insulin & glucose tolerance, however decreased serum lipids and protected the liver from steatosis induced by the high-fat diet. Our results suggest that MA was not able to improve glycaemic parameters, however, had hepatoprotective effect & minimizes changes in lipid metabolism caused by high-fat diet intake, which can relate mainly to the phenolic compounds present in this fruit.

   • According to Bairy KL (2005)

     Excerpt to study the effect of Syzygium malaccense on serum glucose, lipid profile & liver glycogen content in both normal & hyperglycemic rats. Methods: The aqueous & alcoholic extracts were compared with glibenclamide for their influence on fasting blood sugar, lipid profile & liver glycogen in both normoglycemic & to streptozotocin induced (50mg/kg ip) hyperglycemic rats.

   • According to Sobeh M (2018)

     Excerpt Syzygium aqueum: A polyphenol- rich leaf extract exhibits antioxidant, hepatoprotective, pain-killing & anti- inflammatory activities in animal models.

   • According to Frauches NS (2021)

     Excerpt The aim of this work was to characterize & compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ), jamun-berry (Syzygium cumini, SC), & malay-apple (Syzygium malaccense, SM) extracts & their influence on antioxidant activity in vitro & antiproliferative effects on human colon adenocarcinoma cells.

   • According to Gibbert L. (2021)

     Excerpt This finding revealed that these fruits have antiproliferative activity against a lung carcinoma cell, where the highest concentration tested (2 mg/mL) was able to inhibit almost 80% of cell proliferation.

3. 3

   Bacterial infection: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sukandar EY (2020)

     Excerpt Antibacterial activity & combination extract with antibiotics were evaluated using agar diffusion method on Staphylococcus aureus, Bacillus subtilis, Escherichia coli, & Pseudomonas aeruginosa. The objectives of this study are to investigate antibacterial activity of 11 extracts from ten plants which were used in traditional medicine in Indonesia to treat infection disease & to evaluate interaction between potential antibacterial extract & antibiotics.

   • According to BHAVI SM (2025)

     Excerpt This study demonstrates the potential of SM-AgNPs in biomedical applications, emphasizing selective anticancer activity & antimicrobial effects in vivo. Additionally, SM-AgNPs increased Caenorhabditis elegans survival & reduced paralysis under pathogenic bacterial exposure.

   • According to Hapida Y (2021)

     Excerpt Hapida Y et al, Biodiversity & antibacterial activity of endophytic fungi isolated from jambù bol (Syzygium malaccense).

   • According to Author (2015)

     Excerpt Bioactive constituents, antioxidant & antimicrobial activities of three cultivars of wax apple (Syzygium samarangense L.) fruits, Res Jl of Biotechnol,10(1); 7 – 16, 2015-.

   • According to Quenon C (2022)

     Excerpt All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), & their structure–activity relationships were discussed. Bibliographical investigations & antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.