Tagetes erecta (Marigold) : medicinal properties in alcoholic extraction

Tagetes erecta (Marigold, Œillet d’Inde) — family Astéracées.

Scientific synonyms : Tagetes corymbosa Sweet, T erecta var. erecta, T ernstii H.Rob. & Nicolson, T excelsa Soule, T heterocarpha Rydb., T patula L., T remotiflora Kuntze, T tenuifolia Millsp..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 30 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 108 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: normalisation of serum parameters: ALP, GPT, GOT, total bilirubin, cirrhosis, hepatitis, fatty liver, liver necrosis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vidyadhar KM (2019)

     Excerpt The results showed that the treatment of extract significantly lowered the CCl4induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, total bilirubin Liver histopathology showed that extract reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, & fibrous connective tissue proliferation induced by CCl4 in rats. In this study, the protective effects of water -ethanol extract of TE leaves against liver damage were evaluated in carbon tetrachloride (CCl4) induced chronic hepatotoxicity in rats.

   • According to Chaniad P (2021)

     Excerpt Moreover, no significant alterations in the biochemical parameters of liver & kidney function & no histological changes in the liver or kidney tissues were observed. Biochemical parameters of liver & kidney function & the histopathology of liver & kidney tissues of the acute toxicity group were then examined.

   • According to NIKKON F (2009)

     Excerpt Tagetes erecta has been used in folk medicine for the cure of eye diseases, colds conjunctivitis, rheumatism, coughs, bleeding piles & ulcers. Treatment of chloroform fraction at 200 a&400 mg/kg doses, did not make any significant alterations on the hematological & biochemical parameters of rats when data were compared with that of untreated controls.

   • According to Kuzhuvelil Bhaskarannair H (2008)

     Excerpt Administration of lutein & ester form did not alter the hepatic & renal function, & did not produce any change in the hematological parameters & in lipid profile.

   • According to Safar A (n.d.)

     Excerpt Aim of the study: Considering the lack of scientific studies of TE the present study was aimed to evaluate the chemical composition, antifungal activity of its essential oil against fungi responsible for human infections, as well as its cytotoxicity on HepG2 human liver carcinoma cell lines. T erecta, an important specie from this genus, was widely known for its traditional medicine.

2. 2

   Type II diabetes mellitus

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nunez S (2020)

     Excerpt Both types of TE showed lower IC50 values in the α-glucosidase assay than the reference drug acarbose & higher inhibition AGEs formation potential than the reference substance aminoguanidine, they also obtained important values of antiradical activity.The flowers of TE can be considered as source of polyphenol bioactive compounds with interesting properties as functional foods in the prevention & improvement of chronic diseases such as diabetes. Type II diabetes (T2D) is mainly treated with oral antidiabetic drugs.

   • According to Rodda R (2013)

     Excerpt The present study deals with comparative study on anti-diabetic effect of the two ethnomedicinally important plants, Tagetes erecta belongs to the family Compositae & Foeniculum vulgare belongs to the family Umbelliferae in streptozotocin induced diabetic rats. The extract was subjected first to preliminary phytochemical screening, acute toxicity studies and pharmacological screening of anti-diabetic activity in streptozotocin induced diabetic rats.

   • According to Sathi SI (2012)

     Excerpt The results demonstrate that the methanolic extract possesses considerable antihyperglycemic potential, & which is comparable to that of glibenclamide at the highest dose of the extract tested. The antihyperglycemic & antinociceptive potential of Tagetes patula stems, a plant used in folk medicines of Bangladesh for treatment of pain, inflammation, cuts & wounds, & lowering of blood sugar were investigated.

   • According to Rodda R (2011)

     Excerpt Rodda R et al, Antidiabetic potential of Tagetes erecta whole plant in streptozotocin induced diabetic rats.

   • According to Castañeda R (2023)

     Excerpt The most widely studied traditional plants in terms of pharmacological evidence, bioactive compounds, & mechanisms of action, are Annona muricata L., Carica papaya L., Ipomoea batatas (L.) Lam., Lantana camara L., Sechium edule (Jacq.) Sw., Tagetes erecta L., & Zea mays L. A total of 208 plants used for kidney-related problems by 10 Mayan groups were found, representing 143 native species, where only 42 have reported pharmacological activity against kidney damage, mainly approached by in vitro & in vivo models of chemical- or drug-induced nephrotoxicity, diabetes nephropathy, & renal injury produced by hypertension.

3. 3

   Cancer: adjuvant treatment of colorectal and liver carcinoma

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chaniad P (2021)

     Excerpt To investigate the antimalarial effects and toxicity of the extracts of the flowers of Tagetes erecta L. Moreover, no significant alterations in the biochemical parameters of liver & kidney function & no histological changes in the liver or kidney tissues were observed.

   • According to Vidyadhar KM (2019)

     Excerpt In this study, the protective effects of water -ethanol extract of TE leaves against liver damage were evaluated in carbon tetrachloride (CCl4) induced chronic hepatotoxicity in rats. The results showed that the treatment of extract significantly lowered the CCl4induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, total bilirubin Liver histopathology showed that extract reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, & fibrous connective tissue proliferation induced by CCl4 in rats.

   • According to Meurer MC (2019)

     Excerpt Given the role of oxidative stress in ulcerative colitis (UC) etiology & the amount of lutein (a carotenoid with antioxidant properties) in the dry hydroalcoholic extract of Tagetes erecta flowers (DHETE), this study investigated the intestinal anti-inflammatory properties of DHETE in an animal model of UC. The treatment with DHETE decreased myeloperoxidase activity as well as tumor necrosis factor & interleukin-6 levels.

   • According to Kumar R (2010)

     Excerpt Lutein is found in many plants, but the purest & richest source is the petals of marigold flowers (Tagetes erecta L.). Lutein is associated with the prevention of many chronic diseases, like age-related macular degeneration, cancer & cardiovascular diseases.

   • According to Gonzalez ASC (2023)

     Excerpt Tagetes erecta is a plant of great cultural value, & recent reports have suggested its cytotoxic effects in tumor cells. In vivo, a xenograft lung carcinoma model was performed with LLC cells implanted on C57BL/6 mice, which showed that the floral extract reduced tumor growth & improved the effect of etoposide.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.