Taraxacum officinale (Dandelion) : medicinal properties in alcoholic extraction

Taraxacum officinale (Dandelion, Pisanli, Pissenlit, Dent-de-lion) — family Astéracées.

Scientific synonyms : Crepis taraxacum (L.) Stokes, Leontodon taraxacum L., Taraxacum campylodes G.E.Haglund, T dens-Leonis-Desv, Tofficinale (L.) Weber ex F. H. Wigg., T subspathulatum A.J.Richards, T vulgare (Lam.) Shrank.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 140 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chungmu P (2010)

     Excerpt in this work, we estimate the inhibitory effect of two polysaccharides from Taraxacum officinale (TOP) on CCl4-induced oxidative stress & inflammation in Sprague–Dawley rats. TOPs pretreatment also reversed other hepatitis-associated symptoms, including GSH depletion, inhibited anti-oxidative enzyme activities, up-regulation of NF-κB & increased expression of its regulatory inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, tumor necrosis factor(TNF)-α, & interleukin (IL)-1β.

   • According to Hamza A.A (2020)

     Excerpt the study was conducted to evaluate the effects of whole plant powder of dandelion (Taraxacum officinale) on liver fibrosis. The total antioxidant study of TO extract revealed that TO has notable ferric reducing antioxidant power and high total phenolic content.Conclusion : Finally, these results suggest that dandelion prevents the progression of hepatic fibrosis induced by CCL4.

   • According to Domitrović, R (2010)

     Excerpt Conclusions : Our results suggest the therapeutic effect of DWE on CCl4-induced liver fibrosis by the inactivation of hepatic stellate cells & the enhancement of hepatic regenerative capabilities. The present study was aimed to assess the efficacy of dandelion root water–ethanol extract (DWE) in carbon tetrachloride (CCl4)-induced hepatic fibrosis.

   • According to Pfingsgraf LO (2021)

     Excerpt Taraxacum officinale (TO) or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model.

   • According to Davaatseren M (2013)

     Excerpt The purpose of this study is to determine the protective effect of Taraxacum official(dandelion) leaf extract (DLE) on high-fat-diet (HFD)-induced hepatic steatosis, & elucidate the molecular mechanisms behind its effects. Body & liver weights of the DL & DH groups were significantly lesser than those of the HFD group, and DLE supplementation dramatically suppressed triglyceride (TG), total cholesterol (TC), insulin, fasting glucose level in serum, & Homeostatic Model Assessment Insulin Resistance (HOMA-IR) induced by HFD.

2. 2

   Type II diabetes mellitus, synergistic combination with leaf extract

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sharma M (2023)

     Excerpt Taraxacum officinale play an important role in the prophylaxis & treatment of cardiovascular disease (CVD). This study not only explored the overall cardioprotective potential but also tried to explore its molecular mechanism using pharmacological inhibition via L-NAME & glibenclamide.

   • According to Ricky DC (2019)

     Excerpt This study uses True Experimental Design, 22 male rats are divided into five groups: Negative Control (Group I), Positive Control (group II), Experiment I (group III): Rats were induced by alloxan and given extracted jombang leaves orally as much as 0.4 ml (0.65 gram), 0.6 ml (0.97 gram), and 0.8 ml (1.29gram), Experiment II (group IV): Rats were induced by alloxan & given extracted jombang roots orally as much as 0.4 ml (0.77 grams), 0.6 ml (1.15 grams) & 0.8 ml (1.54 grams) & Experiment III (Group v): Rats were induced by alloxan & given extracted as much mixture of leaves & roots of TO 0.4 ml (0.71 gram), 0.6 ml (1.06 gram) and 0.8 ml (1.42 gram). The result showed that the volume of group leaf extract, robot extract and the mixture of leaf & root extract 0.4 ml (0.65 g), 0.6 ml (0.97 g), and 0.8 ml (1.29 ml) can reducing blood glucose levels in alloxan-induced ratsat the end of the Study.

   • According to Frag MR (2022)

     Excerpt Taraxacum officinale, also known as dandelion herb, is a popular medicinal and therapeutic herb used for many years and is mostly raised in Europe, Asia, North & South America. This herb also has various beneficial functions, such as immunomodulatory effects, stimulation of the digestive system & insulin activation, enhancing the metabolism of androgens, & acting as a probiotic, antiangiogenic, antineoplastic & demulcent.

   • According to Davaatseren M (2013)

     Excerpt Body & liver weights of the DL & DH groups were significantly lesser than those of the HFD group, and DLE supplementation dramatically suppressed triglyceride (TG), total cholesterol (TC), insulin, fasting glucose level in serum, & Homeostatic Model Assessment Insulin Resistance (HOMA-IR) induced by HFD. The purpose of this study is to determine the protective effect of Taraxacum official(dandelion) leaf extract (DLE) on high-fat-diet (HFD)-induced hepatic steatosis, & elucidate the molecular mechanisms behind its effects.

   • According to Wirngo FE (2016)

     Excerpt This review recapitulates previous work on dandelion & its potential for the treatment & prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, & their potential mechanisms of action in T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, & sesquiterpene lactones.

3. 3

   Type II diabetes mellitus: synergistic combination with root extract

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sharma M (2023)

     Excerpt Taraxacum officinale play an important role in the prophylaxis & treatment of cardiovascular disease (CVD). This study not only explored the overall cardioprotective potential but also tried to explore its molecular mechanism using pharmacological inhibition via L-NAME & glibenclamide.

   • According to Ricky DC (2019)

     Excerpt This study uses True Experimental Design, 22 male rats are divided into five groups: Negative Control (Group I), Positive Control (group II), Experiment I (group III): Rats were induced by alloxan and given extracted jombang leaves orally as much as 0.4 ml (0.65 gram), 0.6 ml (0.97 gram), and 0.8 ml (1.29gram), Experiment II (group IV): Rats were induced by alloxan & given extracted jombang roots orally as much as 0.4 ml (0.77 grams), 0.6 ml (1.15 grams) & 0.8 ml (1.54 grams) & Experiment III (Group v): Rats were induced by alloxan & given extracted as much mixture of leaves & roots of TO 0.4 ml (0.71 gram), 0.6 ml (1.06 gram) and 0.8 ml (1.42 gram). The result showed that the volume of group leaf extract, robot extract and the mixture of leaf & root extract 0.4 ml (0.65 g), 0.6 ml (0.97 g), and 0.8 ml (1.29 ml) can reducing blood glucose levels in alloxan-induced ratsat the end of the Study.

   • According to Davaatseren M (2013)

     Excerpt Body & liver weights of the DL & DH groups were significantly lesser than those of the HFD group, and DLE supplementation dramatically suppressed triglyceride (TG), total cholesterol (TC), insulin, fasting glucose level in serum, & Homeostatic Model Assessment Insulin Resistance (HOMA-IR) induced by HFD. The purpose of this study is to determine the protective effect of Taraxacum official(dandelion) leaf extract (DLE) on high-fat-diet (HFD)-induced hepatic steatosis, & elucidate the molecular mechanisms behind its effects.

   • According to Frag MR (2022)

     Excerpt Taraxacum officinale, also known as dandelion herb, is a popular medicinal and therapeutic herb used for many years and is mostly raised in Europe, Asia, North & South America. This herb also has various beneficial functions, such as immunomodulatory effects, stimulation of the digestive system & insulin activation, enhancing the metabolism of androgens, & acting as a probiotic, antiangiogenic, antineoplastic & demulcent.

   • According to Wirngo FE (2016)

     Excerpt This review recapitulates previous work on dandelion & its potential for the treatment & prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, & their potential mechanisms of action in T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, & sesquiterpene lactones.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.