Tephrosia purpurea (Lannivraj) : medicinal properties in alcoholic extraction

Tephrosia purpurea (Lannivraj, Digo-savann, Ennivrage, Indigo-à-savane) — family Fabacées.

Scientific synonyms : Cracca purpurea-L., Tephrosia lanceifolia-Link., T leptostachya-DC..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 32 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 139 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: chemoprevention of hepatocellular carcinoma

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hussain T (2012)

     Excerpt The chemopreventive potential of Tephrosia purpurea extract (TPE) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma (HCC) in Wistar rats was assessed. Conclusions :These findings powerfully support that TP prevented lipid peroxidation, suppressed the tumour burden, & promoted enzymatic & nonenzymatic antioxidant defence systems during NDEA-induced hepatocarcinogenesis.

   • According to Gnana-raja R (2014)

     Excerpt The aim of the present study is to divulge the preventive nature of Tephrosia purpurea Methanolic Extract (TpME) during DiEthylNitrosAmine (DENA) induced liver cancer in male Swiss albino mice. Anticancer activity of methanolic extract of Tephrosia purpurea was evaluated in DENA induced Swiss albino mice at the doses of 200 and 300 mg/kg body weight orally and both doses were administered for 14 days.

   • According to Padmapriya R (2017)

     Excerpt Tephrosia purpurea is an Indian herb used in traditional medicine to treat various diseases such as jaundice, asthma, liver & urinary disorders. Therefore, this study aims to investigate the anti-cancer activity of TP in HepG2 hepatocellular carcinoma cells.

   • According to Gnanaraja R (2015)

     Excerpt The maximum reduction of liver cancer marker & antioxidant marker were found formulated drug from TP as well as histopathology studies were exhibited maximum improvement against hepatocellular carcinoma. TThe drugs from Tephrosia purpurea to provide new & important leads against various pharmacological targets against cancer & other diseases.

   • According to Hussain T (2012)

     Excerpt The chemopreventive potential of Tephrosia purpurea extract (TPE) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma (HCC) in Wistar rats was assessed. Conclusions: These findings powerfully support that TP prevented lipid peroxidation, suppressed the tumour burden, & promoted enzymatic & nonenzymatic antioxidant defense systems during NDEA-induced hepatocarcinogenesis.

2. 2

   Age-related cataract associated with diabetes

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to BHADADA (2016)

     Excerpt Tephrosia purpurea has been reported to prevent cataract formation in senile cataract model as well as proven effective in STZ induced type 1 diabetes. Methods : We studied the effects of alcoholic extract and flavonoid fraction of TP in streptozotocin (STZ, 45 mg/kg, i.v.)-induced type I diabetic cataract in rats.

   • According to BHADADA S (2015)

     Excerpt BHADADA S et al, Effect of Aqueous Extract of Tephrosia purpurea on Cardiovascular Complications and Cataract Associated with Streptozotocin-induced Diabetes in Rats Indian J of Pharmaceut Sci, 2015-DOI: 10.4103/0250-474X.169037 (43),.

   • According to Arora SK (2021)

     Excerpt purpurea), commonly known as Sarpunkha has been used in traditional systems of medicine to treat diabetes mellitus. purpurea leaves extract, its fractions & main constituent Rutin in diabetic rats.

   • According to Pavana P (2017)

     Excerpt In this experiment, authors evaluated the beneficial role of Tephrosia purpurea Ethanolic seed extract [TpEt] standard (normal) versus streptozotocin [STZ] induced diabetic male albino wistar rats & studied the membrane stabilizing effects of TpEt in diabetic male albino rats. Diabetes mellitus was induced by giving streptozotocin intraperitoneally & blood glucose of above 250 mg/dl was considered diabetes.

   • According to Singh V (2008)

     Excerpt Flavonoids are present widely in Angiospermic plants & are associated with several pharmacological activities including antibacterial, antidiabetic, antifungal, anti-allergic & anti-oxidant activities.

3. 3

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Arora SK (2021)

     Excerpt purpurea), commonly known as Sarpunkha has been used in traditional systems of medicine to treat diabetes mellitus. purpurea leaves extract, its fractions & main constituent Rutin in diabetic rats.

   • According to Pavana P (2017)

     Excerpt In this experiment, authors evaluated the beneficial role of Tephrosia purpurea Ethanolic seed extract [TpEt] standard (normal) versus streptozotocin [STZ] induced diabetic male albino wistar rats & studied the membrane stabilizing effects of TpEt in diabetic male albino rats. Diabetes mellitus was induced by giving streptozotocin intraperitoneally & blood glucose of above 250 mg/dl was considered diabetes.

   • According to BHADADA (2016)

     Excerpt Tephrosia purpurea has been reported to prevent cataract formation in senile cataract model as well as proven effective in STZ induced type 1 diabetes. Methods : We studied the effects of alcoholic extract and flavonoid fraction of TP in streptozotocin (STZ, 45 mg/kg, i.v.)-induced type I diabetic cataract in rats.

   • According to Singh V (2008)

     Excerpt Flavonoids are present widely in Angiospermic plants & are associated with several pharmacological activities including antibacterial, antidiabetic, antifungal, anti-allergic & anti-oxidant activities.

   • According to PAMU P (2017)

     Excerpt Diabetes mellitus was induced by giving streptozotocin intraperitoneally and blood glucose of above 250 mg/dl was considered diabetes. In this experiment, authors evaluated the beneficial role of TP Ethanolic seed extract [Tp Et] standard (normal) versus streptozotocin [STZ] induced diabetic male albino Wistar rats & studied the membrane stabilizing effects of Tp Et in diabetic male albino rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.