Terminalia arjuna (Brown carambola) : medicinal properties in alcoholic extraction

Terminalia arjuna (Brown carambola, Karanbôl mawon, Carambole marron) — family Combretacées.

Scientific synonyms : Pentaptera arjuna -Roxb., ex DC.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 46 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for liver cancer and leukaemia

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sivalokanathan S (2006)

     Excerpt The present investigation was carried out to evaluate the antioxidant nature of ethanolic extract of Terminalia arjuna bark (EETA) on N-nitrosodiethylamine (DEN) induced liver cancer in male Wistar albino rats. EETA extract (400 mg/kg) was given post-orally for 28 days to hepatocellular carcinoma-bearing rats.

   • According to Ragavan B (2006)

     Excerpt Terminalia arjuna bark, an indigenous plant used in ayurvedic medicine in India, primarily as a cardiotonic is also used in treating diabetes, anemia, tumors & hypertension. The present study examined the effect of ethanolic extract (250 & 500 mg/kg body weight) of TA stem bark in alloxan induced diabetic rats & its lipid peroxidation, enzymatic & nonenzymatic activity was investigated in the liver & kidney tissues.

   • According to Chander R (2004)

     Excerpt Terminalia arjuna (T. TA fractions at tested concentrations (50-500 μg/ml) inhibited the oxidative degradation of lipids in human low-density lipoprotein & rat liver microsomes induced by metal ions.

   • According to Varghese A (2016)

     Excerpt Terminalia arjuna is a tree having an extensive medicinal potential in cardiovascular disorders. Our study was to investigate the in vitro CYP2D inhibition potential of TA extracts in rat liver microsomes & to study the influence of aqueous bark extract of T.A on the oral pharmacokinetics & pharmacodynamics of metoprolol succinate in rats.

   • According to Ganesan R (2011)

     Excerpt An ethanolic herbal extract residue was prepared from the seeds of premature fruits of Terminalia arjuna. Low dosage of the herbal extract residue was able to control the tumour volume 35.1% & 32.9% increase in the lifespan was noted both at high & low dosages, respectively.

2. 2

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tahsin R (2021)

     Excerpt This study shows that different doses of TA bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, & inflammation. arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, & antidepressant agent, but in a dose-dependent manner.

   • According to Ragavan B (2006)

     Excerpt Terminalia arjuna bark, an indigenous plant used in ayurvedic medicine in India, primarily as a cardiotonic is also used in treating diabetes, anemia, tumors & hypertension. The present study examined the effect of ethanolic extract (250 & 500 mg/kg body weight) of TA stem bark in alloxan induced diabetic rats & its lipid peroxidation, enzymatic & nonenzymatic activity was investigated in the liver & kidney tissues.

   • According to Chander R (2004)

     Excerpt Terminalia arjuna (T. The lipid lowering activity of these four fractions A, B, C, & D was evaluated in vivo in two models viz., triton WR-1339 induced hyperlipemia in rats as well as fructose rich high fat diet (HFD) fed diabetic- dyslipidemic hamsters.

   • According to MORSHED MA (2011)

     Excerpt MORSHED MA et al, ANTIHYPERGLYCEMIC & LIPID LOWERING EFFECT OF TERMINALIA ARJUNA BARK EXTRACT ON STREPTOZOTOCIN INDICED TYPE 2 DIABETIC MODEL RATS, Int Jl of Pharm & Pharmaceut Sci, 3 :4, 2011,.

   • According to Mohanty IR (2019)

     Excerpt Hypothesis /purpose: Terminalia arjuna, a medicinal herb with antidiabetic & cardioprotective activities may represent a natural DPP-IV Inhibitor, the DPP-IV Inhibitory activity of which may translate into demonstrable therapeutic benefits in setting of diabetes with cardiovascular co-morbidities. Results: T arjuna demonstrated significant DPP-IV Inhibitory, antidiabetic (significant reduction in HbA1C) & cardioprotective effects (restoration of myocardial CPK-MB) in the experimental model of myocardial infarction co-existing with diabetes.

3. 3

   Ulcerative colitis, irritable bowel syndrome

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Cota D (2019)

     Excerpt In view of its anti-inflammatory, antidiarrheal & antioxidant potential, it could be beneficial for the treatment of inflammatory bowel disease (IBD), which is associated with interaction between genetic, environmental factors & intestinal microbiome leading to dysregulated immune responses. Conclusion: TAHA administration relieved the disease activity in TNBS induced colitis by reducing expression of pro-inflammatory cytokines & chemokine, decreasing oxidative stress, & improving plasma zinc level & structure of gut microbiota,.

   • According to Tahsin R (2021)

     Excerpt arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, & antidepressant agent, but in a dose-dependent manner. This study shows that different doses of TA bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, & inflammation.

   • According to Patel NA (2011)

     Excerpt Terminalia arjuna, Centella asiatica & Curcuma longa are reported to possess wound healing, anti-inflammatory, antioxidant & anti-bacterial activities.

   • According to Kapoor D (2014)

     Excerpt Results: Evidence from various in vitro, in vivo & clinical trials reveal the pleiotropic effects of Terminalia arjuna such as anti-atherogenic, hypotensive, inotropic, anti-inflammatory, anti-thrombotic & antioxidant actions for treatment of various cardiovascular disorders. This comprehensive review provides latest updates on traditional use, phytochemistry, pharmacological & toxicological data, clinical efficacy & safety of Terminalia arjuna as well as outlined strategies for future research and development to scientifically validate the therapeutic potential of this plant.

   • According to Subramaniam S (2011)

     Excerpt Terminalia arjuna is a herb of Combretaceae family which contains hypolipidemic compounds & flavonoids with high antioxidative properties. arjuna ethanolic fraction (100 and 200 mg kg(-1) body weight), respectively.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.