Terminalia arjuna (Karanbôl mawon) : vertus médicinales en extraction alcoolique

Terminalia arjuna (Karanbôl mawon, Carambole marron, Brown carambola) — famille Combretacées.

Synonymes scientifiques : Pentaptera arjuna -Roxb., ex DC.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 14 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 46 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique, de la leucémie

   Partie usitée : Écorce.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Sivalokanathan S (2006)

     Extrait The present investigation was carried out to evaluate the antioxidant nature of ethanolic extract of Terminalia arjuna bark (EETA) on N-nitrosodiethylamine (DEN) induced liver cancer in male Wistar albino rats. EETA extract (400 mg/kg) was given post-orally for 28 days to hepatocellular carcinoma-bearing rats.

   • Selon Ragavan B (2006)

     Extrait Terminalia arjuna bark, an indigenous plant used in ayurvedic medicine in India, primarily as a cardiotonic is also used in treating diabetes, anemia, tumors & hypertension. The present study examined the effect of ethanolic extract (250 & 500 mg/kg body weight) of TA stem bark in alloxan induced diabetic rats & its lipid peroxidation, enzymatic & nonenzymatic activity was investigated in the liver & kidney tissues.

   • Selon Chander R (2004)

     Extrait Terminalia arjuna (T. TA fractions at tested concentrations (50-500 μg/ml) inhibited the oxidative degradation of lipids in human low-density lipoprotein & rat liver microsomes induced by metal ions.

   • Selon Varghese A (2016)

     Extrait Terminalia arjuna is a tree having an extensive medicinal potential in cardiovascular disorders. Our study was to investigate the in vitro CYP2D inhibition potential of TA extracts in rat liver microsomes & to study the influence of aqueous bark extract of T.A on the oral pharmacokinetics & pharmacodynamics of metoprolol succinate in rats.

   • Selon Ganesan R (2011)

     Extrait An ethanolic herbal extract residue was prepared from the seeds of premature fruits of Terminalia arjuna. Low dosage of the herbal extract residue was able to control the tumour volume 35.1% & 32.9% increase in the lifespan was noted both at high & low dosages, respectively.

2. 2

   Diabète mellitus de type II

   Partie usitée : Écorce.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Tahsin R (2021)

     Extrait This study shows that different doses of TA bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, & inflammation. arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, & antidepressant agent, but in a dose-dependent manner.

   • Selon Ragavan B (2006)

     Extrait Terminalia arjuna bark, an indigenous plant used in ayurvedic medicine in India, primarily as a cardiotonic is also used in treating diabetes, anemia, tumors & hypertension. The present study examined the effect of ethanolic extract (250 & 500 mg/kg body weight) of TA stem bark in alloxan induced diabetic rats & its lipid peroxidation, enzymatic & nonenzymatic activity was investigated in the liver & kidney tissues.

   • Selon Chander R (2004)

     Extrait Terminalia arjuna (T. The lipid lowering activity of these four fractions A, B, C, & D was evaluated in vivo in two models viz., triton WR-1339 induced hyperlipemia in rats as well as fructose rich high fat diet (HFD) fed diabetic- dyslipidemic hamsters.

   • Selon MORSHED MA (2011)

     Extrait MORSHED MA et al, ANTIHYPERGLYCEMIC & LIPID LOWERING EFFECT OF TERMINALIA ARJUNA BARK EXTRACT ON STREPTOZOTOCIN INDICED TYPE 2 DIABETIC MODEL RATS, Int Jl of Pharm & Pharmaceut Sci, 3 :4, 2011,.

   • Selon Mohanty IR (2019)

     Extrait Hypothesis /purpose: Terminalia arjuna, a medicinal herb with antidiabetic & cardioprotective activities may represent a natural DPP-IV Inhibitor, the DPP-IV Inhibitory activity of which may translate into demonstrable therapeutic benefits in setting of diabetes with cardiovascular co-morbidities. Results: T arjuna demonstrated significant DPP-IV Inhibitory, antidiabetic (significant reduction in HbA1C) & cardioprotective effects (restoration of myocardial CPK-MB) in the experimental model of myocardial infarction co-existing with diabetes.

3. 3

   Colite ulcérative, inflammation du côlon irritable

   Partie usitée : Écorce.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Cota D (2019)

     Extrait In view of its anti-inflammatory, antidiarrheal & antioxidant potential, it could be beneficial for the treatment of inflammatory bowel disease (IBD), which is associated with interaction between genetic, environmental factors & intestinal microbiome leading to dysregulated immune responses. Conclusion: TAHA administration relieved the disease activity in TNBS induced colitis by reducing expression of pro-inflammatory cytokines & chemokine, decreasing oxidative stress, & improving plasma zinc level & structure of gut microbiota,.

   • Selon Tahsin R (2021)

     Extrait arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, & antidepressant agent, but in a dose-dependent manner. This study shows that different doses of TA bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, & inflammation.

   • Selon Patel NA (2011)

     Extrait Terminalia arjuna, Centella asiatica & Curcuma longa are reported to possess wound healing, anti-inflammatory, antioxidant & anti-bacterial activities.

   • Selon Kapoor D (2014)

     Extrait Results: Evidence from various in vitro, in vivo & clinical trials reveal the pleiotropic effects of Terminalia arjuna such as anti-atherogenic, hypotensive, inotropic, anti-inflammatory, anti-thrombotic & antioxidant actions for treatment of various cardiovascular disorders. This comprehensive review provides latest updates on traditional use, phytochemistry, pharmacological & toxicological data, clinical efficacy & safety of Terminalia arjuna as well as outlined strategies for future research and development to scientifically validate the therapeutic potential of this plant.

   • Selon Subramaniam S (2011)

     Extrait Terminalia arjuna is a herb of Combretaceae family which contains hypolipidemic compounds & flavonoids with high antioxidative properties. arjuna ethanolic fraction (100 and 200 mg kg(-1) body weight), respectively.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.