Terminalia chebula (Tibetan Mirobolan) : medicinal properties in alcoholic extraction

Terminalia chebula (Tibetan Mirobolan, Mirobolan du Tibet) — family Combretacées.

Scientific synonyms : Buceras chebula (Retz.) Lyons, Combretum argyrophyllumK.Schum, Myrobalanus chebula (Retz.) Gaertn, M gangetica (Roxb.) Kostel, M tomentella Kuntze, Terminalia acutae Walp, T argyrophylla King & Prain, T gangetica Roxb., T glandulipetiolata De Wild., T parviflora Th, T reticulata Roth, T tomentella Kurz, T zeylanica Van H & Müll. Arg..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 208 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Singh MP (2009)

     Excerpt Chebula fruit was evaluated for its wound healing activity in alloxan induced diabetic rats using excision and dead space wound models. TC promotes significant wound healing in diabetic rats & further evaluation of this activity in humans is suggested,.

   • According to HUANG YN (2012)

     Excerpt In the present study, we firstly compared rat intestinal α-glucosidase inhibitory activity by different ethanol-aqueous extractions from the dried fruits of Terminalia chebula Retz. Further animal studies revealed that the oral administration of chebulagic acid (100 mg/kg body weight) significantly reduced postprandial blood glucose levels by 11.1% in maltose-loaded Sprague-Dawley (SD) rats compared with the control group, whereas the oral administration of chebulagic acid did not show a suppressive effect on postprandial hyperglycemia in sucrose- or glucose-loaded SD-rats.

   • According to Senthil Kumar GP (2006)

     Excerpt The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats.

   • According to LEE HS (2010)

     Excerpt The aqueous extract of Terminalia chebular fruits was reported to have anti-hyperglycemia & anti-diabetic complication effects. Conclusions: The present study shows the effects of chebulic acid against the progression of AGE-induced endothelial cell dysfunction suggesting that this compound may constitute a promising intervention agent against diabetic vascular complications.

   • According to SHYNI GL (2014)

     Excerpt The thiazolidinedione (TZDs) class of drugs are very effective for the treatment of type 2 diabetes mellitus (T2DM). The comparison of results of various parameters of adipogenesis, insulin sensitivity, endocrine function & molecular docking experiments of roziglitazone & chebulagic acid indicate that the latter behaves like partial PPARγ agonist which could be exploited for phytoceutical development against T2DM.

2. 2

   Cancer: adjuvant treatment for adenocarcinoma: colorectal, breast, oral squamous cell and lung

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to DEVI ST (2025)

     Excerpt This study aims to explore the therapeutic potential of the hydroalcoholic extract of TC fruits & its fractions against oral squamous cell carcinoma (OSCC) using SCC9 cells focusing on their cytotoxicity, anti-proliferative effect & the synergistic action of its ethyl-acetate fraction with cisplatin (CP). chebula against oral cancer has not been explored, warranting further investigation into its bioactive properties.

   • According to MEHRABANI M (2021)

     Excerpt The current research work was intended to explore the cytotoxic activity of ethanol & ethyl acetate extracts of dried fruit of Terminalia chebula Retz. These data represent that Tc may be a valuable medicinal resource in the regulation of breast cancer proliferation, growth, & metastasis.

   • According to DEVI ST (2023)

     Excerpt The hydroalcoholic extract obtained from four fruit samples of TC collected from different locations in Manipur were analyzed using gas chromatography-mass spectrometry (GC-MS) & high-performance thin-layer chromatography (HPTLC) for their chemical constituents & evaluated for their anticancer activity against the colon cancer cell HCT 116. Terminalia chebula Retz.

   • According to Pfundstein B (2010)

     Excerpt Thirty-four polyphenolic substances in methanol extracts of the fruits of Terminalia bellerica, Terminalia chebula & Terminalia horrida, three plants used in Egyptian folk medicine, were initially identified by HPLC-ESI-MS & quantitated by analytical HPLC after column chromatography on Sephadex LH-20. Antioxidant capacities of the raw fruit extracts & the major isolated substances were determined using the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), oxygen radical absorbance capacity (ORAC) & ferric reducing ability of plasma (FRAP) in vitro assays & indicated that chebulic ellagitannins have high activity which may correlate with high potential as cancer chemopreventive agents.

   • According to WANG C (2024)

     Excerpt Terminalia chebula Retz., known for its dried fruit, namely Chebulae Fructus, is a medicinal plant with a long-standing global reputation, which was initially recognized for its therapeutic properties during the Jin Dynasty. These compounds confer a broad spectrum of biological activities in vitro & in vivo, such as antioxidant, anti-inflammatory, antiviral, anticancer, antibacterial, hepatoprotective, nephroprotective, neuroprotective, & anti-diabetic, some of which are already integrated into clinical practice.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ekambaram SP (2020)

     Excerpt Terminalia chebula Retz. The anti-inflammatory efficacy of HTF was further demonstrated by morphological observation, histopathological , & radiological evaluations.

   • According to Bag A (n.d.)

     Excerpt Arthritis is inflammation of one or more joints. Terminalia chebula Retz.

   • According to Rahimi VB (2018)

     Excerpt Our results suggest that TC extract reduces inflammation in microglial cells & can be used as a potential anti-inflammatory agent in central nervous system inflammatory diseases. Teminalia chebula (TC) has been traditionally used in the Iranian traditional medicine (ITM) and Ayurvedic medicine primarily for neurologic disorders and inflammation.

   • According to Lee J (2017)

     Excerpt The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. In the quest for materials that will prove useful in the treatment & prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of TC(EETC) on DPB-induced inflammation & bone resorption.

   • According to Gaire BP (2013)

     Excerpt chebula might protect neuronal cells against ischemia & related diseases by reduction of oxidative damage & inflammation in rat pheochromocytoma cells (PC12) using in vitro oxygen-glucose deprivation followed by reoxygenation (OGD-R) ischemia & hydrogen peroxide (H2O2) induced cell death. Terminalia chebula, native to Southeast Asia, is a popular medicinal plant in Ayurveda.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.