Terminalia chebula (Mirobolan du Tibet) : vertus médicinales en extraction alcoolique

Terminalia chebula (Mirobolan du Tibet, Tibetan Mirobolan) — famille Combretacées.

Synonymes scientifiques : Buceras chebula (Retz.) Lyons, Combretum argyrophyllumK.Schum, Myrobalanus chebula (Retz.) Gaertn, M gangetica (Roxb.) Kostel, M tomentella Kuntze, Terminalia acutae Walp, T argyrophylla King & Prain, T gangetica Roxb., T glandulipetiolata De Wild., T parviflora Th, T reticulata Roth, T tomentella Kurz, T zeylanica Van H & Müll. Arg..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 22 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 208 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Fruit. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Singh MP (2009)

     Extrait Chebula fruit was evaluated for its wound healing activity in alloxan induced diabetic rats using excision and dead space wound models. TC promotes significant wound healing in diabetic rats & further evaluation of this activity in humans is suggested,.

   • Selon HUANG YN (2012)

     Extrait In the present study, we firstly compared rat intestinal α-glucosidase inhibitory activity by different ethanol-aqueous extractions from the dried fruits of Terminalia chebula Retz. Further animal studies revealed that the oral administration of chebulagic acid (100 mg/kg body weight) significantly reduced postprandial blood glucose levels by 11.1% in maltose-loaded Sprague-Dawley (SD) rats compared with the control group, whereas the oral administration of chebulagic acid did not show a suppressive effect on postprandial hyperglycemia in sucrose- or glucose-loaded SD-rats.

   • Selon Senthil Kumar GP (2006)

     Extrait The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats.

   • Selon LEE HS (2010)

     Extrait The aqueous extract of Terminalia chebular fruits was reported to have anti-hyperglycemia & anti-diabetic complication effects. Conclusions: The present study shows the effects of chebulic acid against the progression of AGE-induced endothelial cell dysfunction suggesting that this compound may constitute a promising intervention agent against diabetic vascular complications.

   • Selon SHYNI GL (2014)

     Extrait The thiazolidinedione (TZDs) class of drugs are very effective for the treatment of type 2 diabetes mellitus (T2DM). The comparison of results of various parameters of adipogenesis, insulin sensitivity, endocrine function & molecular docking experiments of roziglitazone & chebulagic acid indicate that the latter behaves like partial PPARγ agonist which could be exploited for phytoceutical development against T2DM.

2. 2

   Cancer: traitement adjuvant de l’adénocarcinome: colorectal, mammaire, oral squameux & pulmonaire

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon DEVI ST (2025)

     Extrait This study aims to explore the therapeutic potential of the hydroalcoholic extract of TC fruits & its fractions against oral squamous cell carcinoma (OSCC) using SCC9 cells focusing on their cytotoxicity, anti-proliferative effect & the synergistic action of its ethyl-acetate fraction with cisplatin (CP). chebula against oral cancer has not been explored, warranting further investigation into its bioactive properties.

   • Selon MEHRABANI M (2021)

     Extrait The current research work was intended to explore the cytotoxic activity of ethanol & ethyl acetate extracts of dried fruit of Terminalia chebula Retz. These data represent that Tc may be a valuable medicinal resource in the regulation of breast cancer proliferation, growth, & metastasis.

   • Selon DEVI ST (2023)

     Extrait The hydroalcoholic extract obtained from four fruit samples of TC collected from different locations in Manipur were analyzed using gas chromatography-mass spectrometry (GC-MS) & high-performance thin-layer chromatography (HPTLC) for their chemical constituents & evaluated for their anticancer activity against the colon cancer cell HCT 116. Terminalia chebula Retz.

   • Selon Pfundstein B (2010)

     Extrait Thirty-four polyphenolic substances in methanol extracts of the fruits of Terminalia bellerica, Terminalia chebula & Terminalia horrida, three plants used in Egyptian folk medicine, were initially identified by HPLC-ESI-MS & quantitated by analytical HPLC after column chromatography on Sephadex LH-20. Antioxidant capacities of the raw fruit extracts & the major isolated substances were determined using the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), oxygen radical absorbance capacity (ORAC) & ferric reducing ability of plasma (FRAP) in vitro assays & indicated that chebulic ellagitannins have high activity which may correlate with high potential as cancer chemopreventive agents.

   • Selon WANG C (2024)

     Extrait Terminalia chebula Retz., known for its dried fruit, namely Chebulae Fructus, is a medicinal plant with a long-standing global reputation, which was initially recognized for its therapeutic properties during the Jin Dynasty. These compounds confer a broad spectrum of biological activities in vitro & in vivo, such as antioxidant, anti-inflammatory, antiviral, anticancer, antibacterial, hepatoprotective, nephroprotective, neuroprotective, & anti-diabetic, some of which are already integrated into clinical practice.

3. 3

   Arthrose, arthrite, rhumatisme, oedeme

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ekambaram SP (2020)

     Extrait Terminalia chebula Retz. The anti-inflammatory efficacy of HTF was further demonstrated by morphological observation, histopathological , & radiological evaluations.

   • Selon Bag A (s.d.)

     Extrait Arthritis is inflammation of one or more joints. Terminalia chebula Retz.

   • Selon Rahimi VB (2018)

     Extrait Our results suggest that TC extract reduces inflammation in microglial cells & can be used as a potential anti-inflammatory agent in central nervous system inflammatory diseases. Teminalia chebula (TC) has been traditionally used in the Iranian traditional medicine (ITM) and Ayurvedic medicine primarily for neurologic disorders and inflammation.

   • Selon Lee J (2017)

     Extrait The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. In the quest for materials that will prove useful in the treatment & prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of TC(EETC) on DPB-induced inflammation & bone resorption.

   • Selon Gaire BP (2013)

     Extrait chebula might protect neuronal cells against ischemia & related diseases by reduction of oxidative damage & inflammation in rat pheochromocytoma cells (PC12) using in vitro oxygen-glucose deprivation followed by reoxygenation (OGD-R) ischemia & hydrogen peroxide (H2O2) induced cell death. Terminalia chebula, native to Southeast Asia, is a popular medicinal plant in Ayurveda.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.