Thevetia peruviana (Nwa-sèpan) : medicinal properties in alcoholic extraction

Thevetia peruviana (Nwa-sèpan, Snake nut, Noix-à-serpent) — family Apocynacées.

Scientific synonyms : Cascabela peruviana (Pers.) Raf., C Thevetia-(L), Cerbera thevetia Linn., Thevetia linearis A. DC.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 61 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for uterine carcinoma

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Managit C (2017)

     Excerpt Managit C et al, Ethanolic extract of Thevetia peruviana flowers enhances TNF-α & TRAIL-induced apoptosis of human cervical cancer cells via intrinsic & extrinsic pathways, Oncol Lett. peruviana flowers on TNF-α- & TRAIL-induced apoptosis of human cervical cancer HeLa cells were investigated in vitro by determining cell viability & apoptosis using a WST-1 cell proliferation assay and immunoblot analysis, respectively.

   • According to Rajhans S (2020)

     Excerpt has been used against the Triple Negative Human Breast Cancer cell line MDA-MB-231 for the current experiment All the 5 parts (leaf, stem, flower, fruit seed) had been selected for the experiment and the extracts of the various parts were made in hydro-alcoholic solvent i.e., methanol: Water. The plant extracts of Thevetia peruviana (Pers.) K.

   • According to Khang PV (2020)

     Excerpt this study, The essential oil of flowers, fruits, & leaves of Thevetia peruviana, which were collected in Viet Nam, were being reported for the first time. The activities of total essential oil extracts of the T peruviana exhibit inhibitory activities against five cancer cell lines.

   • According to Van Khang P (2020)

     Excerpt in this study, the essential oil of flowers, fruits, & leaves of Thevetia peruviana, which were collected in Vietnam, were being reported for the first time. The essential oil of flowers was extracted by different methods: n-hexane extraction, distillation water, & supercritical CO2 extraction.

   • According to Ramos-Silva A (2017)

     Excerpt peruviana methanolic extract exhibited cytotoxic activity on four human cancer cell lines: prostate, breast, colorectal & lung, with values of IC50 1.91 ± 0.76, 5.78 ± 2.12, 6.30 ± 4.45 & 12.04 ± 3.43 μg/mL, respectively. peruviana methanolic extract was carried out on human breast, colorectal, prostate & lung cancer cell lines & non-tumorigenic control cells (fibroblast & Vero), using the MTT assay.

2. 2

   Diarrhoea

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hassan MM (2011)

     Excerpt This study screened the antidiarrhoeal, antimicrobial & cytotoxic effects of ethanol-extracted leaves of Thevetia peruviana The extract was tested against castor oil-induced diarrhoea in a model of albino rats & showed significant antidiarrhoeal activity (P<0.01).

   • According to Author (n.d.)

     Excerpt Thevetia peruviana / Poisonous Plants-IPCS INCHEM : Main risks & target organs: The main toxic effects of glycosides found in Thevetia peruviana are related to its digitalis-like action on the heart & severe gastrointestinal irritation. Summary of clinical effects: The common presenting symptoms are: numbness, burning of the mouth, nausea, vomiting, abdominal pain & diarrhoea.

3. 3

   Bacterial infection: Shigella flexineri, Salmonella typhi, Klebsiella sp., Staphylococcus aureus and Shigella sonnei

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hassan MM (2011)

     Excerpt Ethanol-extracted leaves of TP showed narrow zone of inhibition in the bacterial lawns of Shigella flexneri, Salmonella typhi, Klebsiella sp, Staphylococcus aureus & Shigella sonnei. This study screened the antidiarrhoeal, antimicrobial & cytotoxic effects of ethanol-extracted leaves of Thevetia peruviana The extract was tested against castor oil-induced diarrhoea in a model of albino rats & showed significant antidiarrhoeal activity (P<0.01).

   • According to Al-Rajhi AMH (2022)

     Excerpt TEM examination exhibited ultrastructure changes in cell walls & cell membranes of Staphylococcus aureus & Pseudomonas aeruginosa treated with latex. The study of anticancer, anticoagulant, & antimicrobial activities of Thevetia peruviana latex were the aim of the current research.

   • According to Kareru PG (2010)

     Excerpt From these results, it was concluded that the Thevetia peruviana-based oil paint was self-preserving against microbes & substantially protected wood from subterranean termite attack. The paint exhibited inhibitory activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis & Candida albicans in a concentration dependent manner.

   • According to Ravikumar Patil HS (2008)

     Excerpt The antimicrobial activity of ethanol extract obtained from Thevetia peruviana was tested against bacterial species of Escherichia coli ATCC 69314, Streptococcus lactis NCIM 50038, Enterobacter aerogenes NCIM 2340, Alcaligenes faecalis ATCC 15246, Pseudomonas aeruginosa NCIM 2200, Proteus vulgaris ATCC 6380 and fungal species of Fusarium oxysporum NCIM 1008, Alternaria helianthi ATCC 201540, Curvularia lunata ATCC 34477, Aspergillus niger NCIM 1207 & Penicillium spp NCIM 741.

   • According to Gupta R (2011)

     Excerpt This study was conducted to evaluate the antifertility potential of Thevetia peruviana (Apocynaceae) in male albino rats with their phytochemical evaluations. peruviana stem bark methanol extract (TPMtE) administered orally to male rats at the dose level of 100 mg/rat/day did not cause any significant reduction in body weight, while the weight of reproductive organs reduced significantly.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.