Thevetia peruviana (Nwa-sèpan) : vertus médicinales en extraction alcoolique

Thevetia peruviana (Nwa-sèpan, Noix-à-serpent, Snake nut) — famille Apocynacées.

Synonymes scientifiques : Cascabela peruviana (Pers.) Raf., C Thevetia-(L), Cerbera thevetia Linn., Thevetia linearis A. DC.

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 9 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 61 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome utérin

   Partie usitée : Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Managit C (2017)

     Extrait Managit C et al, Ethanolic extract of Thevetia peruviana flowers enhances TNF-α & TRAIL-induced apoptosis of human cervical cancer cells via intrinsic & extrinsic pathways, Oncol Lett. peruviana flowers on TNF-α- & TRAIL-induced apoptosis of human cervical cancer HeLa cells were investigated in vitro by determining cell viability & apoptosis using a WST-1 cell proliferation assay and immunoblot analysis, respectively.

   • Selon Rajhans S (2020)

     Extrait has been used against the Triple Negative Human Breast Cancer cell line MDA-MB-231 for the current experiment All the 5 parts (leaf, stem, flower, fruit seed) had been selected for the experiment and the extracts of the various parts were made in hydro-alcoholic solvent i.e., methanol: Water. The plant extracts of Thevetia peruviana (Pers.) K.

   • Selon Khang PV (2020)

     Extrait this study, The essential oil of flowers, fruits, & leaves of Thevetia peruviana, which were collected in Viet Nam, were being reported for the first time. The activities of total essential oil extracts of the T peruviana exhibit inhibitory activities against five cancer cell lines.

   • Selon Van Khang P (2020)

     Extrait in this study, the essential oil of flowers, fruits, & leaves of Thevetia peruviana, which were collected in Vietnam, were being reported for the first time. The essential oil of flowers was extracted by different methods: n-hexane extraction, distillation water, & supercritical CO2 extraction.

   • Selon Ramos-Silva A (2017)

     Extrait peruviana methanolic extract exhibited cytotoxic activity on four human cancer cell lines: prostate, breast, colorectal & lung, with values of IC50 1.91 ± 0.76, 5.78 ± 2.12, 6.30 ± 4.45 & 12.04 ± 3.43 μg/mL, respectively. peruviana methanolic extract was carried out on human breast, colorectal, prostate & lung cancer cell lines & non-tumorigenic control cells (fibroblast & Vero), using the MTT assay.

2. 2

   Diarrhée

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hassan MM (2011)

     Extrait This study screened the antidiarrhoeal, antimicrobial & cytotoxic effects of ethanol-extracted leaves of Thevetia peruviana The extract was tested against castor oil-induced diarrhoea in a model of albino rats & showed significant antidiarrhoeal activity (P<0.01).

   • Selon Auteur (s.d.)

     Extrait Thevetia peruviana / Poisonous Plants-IPCS INCHEM : Main risks & target organs: The main toxic effects of glycosides found in Thevetia peruviana are related to its digitalis-like action on the heart & severe gastrointestinal irritation. Summary of clinical effects: The common presenting symptoms are: numbness, burning of the mouth, nausea, vomiting, abdominal pain & diarrhoea.

3. 3

   Infection bactérienne : Shigella flexineri, Salmonella typhi, Klebsiella sp, Staphylococcus aureus & Shigella sonnei

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hassan MM (2011)

     Extrait Ethanol-extracted leaves of TP showed narrow zone of inhibition in the bacterial lawns of Shigella flexneri, Salmonella typhi, Klebsiella sp, Staphylococcus aureus & Shigella sonnei. This study screened the antidiarrhoeal, antimicrobial & cytotoxic effects of ethanol-extracted leaves of Thevetia peruviana The extract was tested against castor oil-induced diarrhoea in a model of albino rats & showed significant antidiarrhoeal activity (P<0.01).

   • Selon Al-Rajhi AMH (2022)

     Extrait TEM examination exhibited ultrastructure changes in cell walls & cell membranes of Staphylococcus aureus & Pseudomonas aeruginosa treated with latex. The study of anticancer, anticoagulant, & antimicrobial activities of Thevetia peruviana latex were the aim of the current research.

   • Selon Kareru PG (2010)

     Extrait From these results, it was concluded that the Thevetia peruviana-based oil paint was self-preserving against microbes & substantially protected wood from subterranean termite attack. The paint exhibited inhibitory activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis & Candida albicans in a concentration dependent manner.

   • Selon Ravikumar Patil HS (2008)

     Extrait The antimicrobial activity of ethanol extract obtained from Thevetia peruviana was tested against bacterial species of Escherichia coli ATCC 69314, Streptococcus lactis NCIM 50038, Enterobacter aerogenes NCIM 2340, Alcaligenes faecalis ATCC 15246, Pseudomonas aeruginosa NCIM 2200, Proteus vulgaris ATCC 6380 and fungal species of Fusarium oxysporum NCIM 1008, Alternaria helianthi ATCC 201540, Curvularia lunata ATCC 34477, Aspergillus niger NCIM 1207 & Penicillium spp NCIM 741.

   • Selon Gupta R (2011)

     Extrait This study was conducted to evaluate the antifertility potential of Thevetia peruviana (Apocynaceae) in male albino rats with their phytochemical evaluations. peruviana stem bark methanol extract (TPMtE) administered orally to male rats at the dose level of 100 mg/rat/day did not cause any significant reduction in body weight, while the weight of reproductive organs reduced significantly.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.