Thymus vulgaris (Diten-frans) : medicinal properties in alcoholic extraction

Thymus vulgaris (Diten-frans, Ti-diten, French thyme, Small thyme, Thym de France, Petit thym) — family Lamiacées.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 24 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 106 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for prostate cancer, lung cancer and leukaemia

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jaafari A (2007)

     Excerpt vulgaris has effective anticancer activity against human lung cancer cells and Human prostate cancer cells and hence could be a potential source of chemotherapeutics for treatment of cancer. The samples were tested for possible anticancer activity by using MTT assay on Human lung(A549) and prostate Cancer (IGR-CAP1) Cell Lines The results of these studies have shown that the ethanolic extract T.

   • According to Soomro S (2019)

     Excerpt Furthermore, for anticancer potential butanol fraction was found to be slightly effective against HeLa cancer cells with percent inhibition of 25%. The current studies are aiming to further explore the phytoconstituents of Thymus vulgaris & its biological activity.

   • According to Zeng Q (2020)

     Excerpt Results: In this study, we tested the antitumor activity of thymol extracted from a Chinese medicinal herb, TV. Increasing evidence has indicated that thymol exerts prominent antitumor effects in a variety of cancers, including CRC.

   • According to Sertel S (2011)

     Excerpt Sertel S et al: Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma. However, it is unknown whether the medicinal plant Thymus vulgaris L.

   • According to Ayesh (2014)

     Excerpt Methods : Ethanol extracts were prepared from Thymus vulgaris. vulgaris represents a potential selective cytostatic & safe target for future anticancer agents’ development.

2. 2

   Bacterial infection: Staphylococcus aureus, Bacillus cereus, Shigella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2008)

     Excerpt Essential oils (EOs) & methanol extracts obtained from aerial parts of Thymus vulgaris & Pimpinella anisum seeds were evaluated for their single & combined antibacterial activities against nine Gram-positive & Gram-negative pathogenic bacteria: Staphylococcus aureus, Bacillus cereus, Escherichia coli, Proteus vulgaris, Proteus mirabilis, Salmonella typhi, Salmonella typhimurium, Klebsiella pneumoniae & Pseudomonas aeruginosa. Maximum activity of TV & PA essential oils & methanol extracts (MIC 15.6 & 62.5mug/ml) were observed against Staphylococcus aureus, Bacillus cereus & Proteus vulgaris.

   • According to Mathkoor MM (2024)

     Excerpt It evaluated their ability to inhibit pathogenic & antibiotic-resistant bacteria, including Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P aeruginosa),& Escherichia coli (E.coli) isolated from skin ulcers. P.aeruginosa was very weak compared to the effectiveness of these EOs o other bacterial species used in the study, where the highest diameter of inhibition of these bacteria was by SA oil & reached 15 mm.

   • According to Micucci M (2020)

     Excerpt The solid EO exhibits antimicrobial activity against different strains (Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli, Salmonella Thyphimurium, Candida albicans) similarly to liquid oil, with activity against pathogen, but not commensal strains (Bifidobacterium Breve, Lactobacillus Fermentum) in intestinal homeostasis. A new Thymus vulgaris L.

   • According to TAHA SM (2024)

     Excerpt This study aimed to evaluate the antimicrobial, antioxidant, & immunomodulatory activities of Lagenaria siceraria, Thymus vulgaris, & their chitosan nanocomposites against extensive drug-resistant (XDR) Pseudomonas aeruginosa & vancomycin-resistant Staphylococcus aureus (VRSA) using both in vitro & in vivo assays. These values returned to the normal range after treatment by chitosan nanoparticles, either loaded with Lagenaria siceraria or Thymus vulgaris.

   • According to Soomro S (2019)

     Excerpt Our results demonstrated that ethanolic extract of TV possesses significant activity against Salmonella typhi, Staphylococcus aureus, & Bacillus subtilis. The current studies are aiming to further explore the phytoconstituents of Thymus vulgaris & its biological activity.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vassiliou E (2023)

     Excerpt Thymus comprises numerous molecular species exhibiting diverse therapeutic properties that are dependent on their biologically active concentrations in the extracted oil. Furthermore, the phenophase of the same plant species has been shown to yield different anti-inflammatory properties.

   • According to Ocaña A (2012)

     Excerpt Properties of thyme extracts from three different species (Thymus vulgaris, Thymus zygis & Thymus hyemalis) were examined. Thyme extracts significantly reduced production & gene expression of the proinflammatory mediators TNF-α, IL-1B & IL-6 & highly increased these parameters on the anti-inflammatory IL-10 cytokine.

   • According to SHALLANGW AGA (2012)

     Excerpt These findings showed that both Moringa oleifera and Thymus vulgaris possessed marked in vitro antiinflammatory effect against the denaturation of protein when compared with the standard anti-inflammatory drug, Ibuprofen. The aim of the present study is to evaluate and compare thein vitro anti-inflammatory effects of ethanol extracts of M oleifera and T vulgaris and a 1:1 blend of the two extracts against the denaturation of proteins.

   • According to Author (2017)

     Excerpt All Thymus vulgaris parts, which bought from Gharian-Libya, were dried, then macerated 3 times, & its ethanol was evaporated. The Thymus vulgaris extracts are effective as anti-inflammatory, Immunomodulatory, antioxidant, antibacterial and antifungal.

   • According to Soomro S (2019)

     Excerpt The current studies are aiming to further explore the phytoconstituents of Thymus vulgaris & its biological activity. Thymus vulgaris (za‟atar) is one of the most famous and traditional spices of Arab countries.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.