Tinospora crispa (Lyenn-Kayenn’) : medicinal properties in alcoholic extraction

Tinospora crispa (Lyenn-Kayenn’, Lyenn sèpan, Cayenne vine, Snake vine, Liane de Cayenne, Liane à-serpent) — family Menispermacées.

Scientific synonyms : Tinospora crispa -(L)-Hook f & Thomson.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 121 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: stem.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Thomas A (2016)

     Excerpt Tinospora crispa is a medicinal plant belonging to the botanical family Menispermaceae. Traditional healers of Thailand, Malaysia, Guyana, Bangladesh & the southern Indian province of Kerala use this plant in the treatment of diabetes.

   • According to Abu NM (2015)

     Excerpt The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine & rich in antioxidant, were explored based on obesity-linked insulin resistance condition. crispa ameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet,.

   • According to Abu MN (2014)

     Excerpt Tinospora crispa, a local herbal plant used as folklore medicine, contains natural insulin enhancer & possesses antiproliferative effects. crispa in compensating insulin resistance thus inducing apoptosis in HepG2 cancer cell line.

   • According to Ounjaijean S (2019)

     Excerpt It can be concluded that TC stem extract may have beneficial properties in protecting against hypoglycemia, & in increasing survival time during malaria infection. During Plasmodium malaria parasite infection in a human, the intraerythrocytic stages lead to the clinical manifestations of the disease, especially hypoglycemia.

   • According to SUTRISNA EM (n.d.)

     Excerpt The aim of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. Conclusion: The present study shows that the 70% EETC at dose of 100 & 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.

2. 2

   Cirrhosis, hepatitis, fatty liver disease

   Plant part used: stem.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Thomas A (2016)

     Excerpt Tinospora crispa is a medicinal plant belonging to the botanical family Menispermaceae. A related species Tinospora cordifolia is used in Ayurveda for treating a large spectrum of diseases.

   • According to Cachet X (2018)

     Excerpt We report here a new case of toxic hepatitis in a 57-year-old male patient in the French West Indies following the consumption of two aqueous extracts of fresh Tinospora crispa stems. Tinospora crispa is a popular traditional herbal plant commonly used throughout the world for treatment of various diseases, in particular type 2 diabetes mellitus.

   • According to Huang WT (2019)

     Excerpt Given that the two herbs were misidentified in these two reports, we investigated the frequency of erroneous identification by using three keywords ("Guduchi", "Tinospora cordifolia", "Tinospora crispa") to search images from the Google Images database. It indicated that TCF exerted liver protection, TCP had a contrary effect, suggesting its cis-Clerodane-type furano-diterpenoids might be an important factor of inducing hepatotoxicity.

   • According to Rakib A (2016)

     Excerpt This research describes an investigation of the antipyretic & hepatoprotective properties of both a crude organic extract & various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In CCl4‐induced hepatotoxicity studies, METC ameliorated elevated hepatic markers including serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), & total bilirubin.

   • According to SUTRISNA EM (n.d.)

     Excerpt The aim of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. Conclusion: The present study shows that the 70% EETC at dose of 100 & 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.

3. 3

   Liver fibrosis

   Plant part used: stem.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Thomas A (2016)

     Excerpt Tinospora crispa is a medicinal plant belonging to the botanical family Menispermaceae. A related species Tinospora cordifolia is used in Ayurveda for treating a large spectrum of diseases.

   • According to Rakib A (2016)

     Excerpt This research describes an investigation of the antipyretic & hepatoprotective properties of both a crude organic extract & various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In CCl4‐induced hepatotoxicity studies, METC ameliorated elevated hepatic markers including serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), & total bilirubin.

   • According to SUTRISNA EM (n.d.)

     Excerpt The aim of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. Conclusion: The present study shows that the 70% EETC at dose of 100 & 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.

   • According to PRANEE C (1997)

     Excerpt Acute toxicity study of ethanolic extract of Tinospora crispa stem in mice showed that the extract at the highest oral dose of 4.0 g/kg of body weight (g/kg BW), which was equivalent to powdered crude drug 28, 95 g/kg BW, did not produce any signs of toxicity. crispa in humans should be avoided or if signs of liver or renal toxicities occur while using T.

   • According to Kadir FA (2011)

     Excerpt This study was conducted to determine the effect of ethanolic extract of the dried stems of Tinospora crispa in a male rat model of hepatic fibrosis caused by the hepatotoxin, thioacetamide. To assess the effectivity of extract, against thioacetamide, the activity of aminotransferases (alanine aminotransferase, aspartate aminotransferase), alkaline phosphatase (AP); & bilirubin were measured, together with morphological & histopathological indices in the liver of healthy & thioacetamide-treated rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.