Tinospora crispa (Lyenn-Kayenn’) : vertus médicinales en extraction alcoolique

Tinospora crispa (Lyenn-Kayenn’, Lyenn sèpan, Liane de Cayenne, Liane à-serpent) — famille Menispermacées.

Synonymes scientifiques : Tinospora crispa -(L)-Hook f & Thomson.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 19 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 121 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Thomas A (2016)

     Extrait Cell culture & animal studies suggest that the herb stimulates secretion of insulin from β-cells. Tinospora crispa is a medicinal plant belonging to the botanical family Menispermaceae.

   • Selon Abu NM (2015)

     Extrait The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine & rich in antioxidant, were explored based on obesity-linked insulin resistance condition. crispa ameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet,.

   • Selon Abu MN (2014)

     Extrait Tinospora crispa, a local herbal plant used as folklore medicine, contains natural insulin enhancer & possesses antiproliferative effects. crispa in compensating insulin resistance thus inducing apoptosis in HepG2 cancer cell line.

   • Selon Ounjaijean S (2019)

     Extrait It can be concluded that TC stem extract may have beneficial properties in protecting against hypoglycemia, & in increasing survival time during malaria infection. During Plasmodium malaria parasite infection in a human, the intraerythrocytic stages lead to the clinical manifestations of the disease, especially hypoglycemia.

   • Selon SUTRISNA EM (s.d.)

     Extrait The aim of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. Conclusion: The present study shows that the 70% EETC at dose of 100 & 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.

2. 2

   Cirrhose, hépatite, stéatose hépatique

   Partie usitée : Tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Thomas A (2016)

     Extrait Tinospora crispa is a medicinal plant belonging to the botanical family Menispermaceae. However, in view of the reported hepatotoxicity, this herb may be used with caution.

   • Selon Cachet X (2018)

     Extrait We report here a new case of toxic hepatitis in a 57-year-old male patient in the French West Indies following the consumption of two aqueous extracts of fresh Tinospora crispa stems. Tinospora crispa is a popular traditional herbal plant commonly used throughout the world for treatment of various diseases, in particular type 2 diabetes mellitus.

   • Selon Huang WT (2019)

     Extrait Given that the two herbs were misidentified in these two reports, we investigated the frequency of erroneous identification by using three keywords ("Guduchi", "Tinospora cordifolia", "Tinospora crispa") to search images from the Google Images database. It indicated that TCF exerted liver protection, TCP had a contrary effect, suggesting its cis-Clerodane-type furano-diterpenoids might be an important factor of inducing hepatotoxicity.

   • Selon Rakib A (2016)

     Extrait This research describes an investigation of the antipyretic & hepatoprotective properties of both a crude organic extract & various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In CCl4‐induced hepatotoxicity studies, METC ameliorated elevated hepatic markers including serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), & total bilirubin.

   • Selon SUTRISNA EM (s.d.)

     Extrait The aim of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. Conclusion: The present study shows that the 70% EETC at dose of 100 & 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.

3. 3

   Fibrose hépatique

   Partie usitée : Tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Thomas A (2016)

     Extrait Tinospora crispa is a medicinal plant belonging to the botanical family Menispermaceae. However, in view of the reported hepatotoxicity, this herb may be used with caution.

   • Selon Rakib A (2016)

     Extrait This research describes an investigation of the antipyretic & hepatoprotective properties of both a crude organic extract & various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In CCl4‐induced hepatotoxicity studies, METC ameliorated elevated hepatic markers including serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), & total bilirubin.

   • Selon SUTRISNA EM (s.d.)

     Extrait The aim of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. Conclusion: The present study shows that the 70% EETC at dose of 100 & 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.

   • Selon PRANEE C (1997)

     Extrait Acute toxicity study of ethanolic extract of Tinospora crispa stem in mice showed that the extract at the highest oral dose of 4.0 g/kg of body weight (g/kg BW), which was equivalent to powdered crude drug 28, 95 g/kg BW, did not produce any signs of toxicity. crispa in humans should be avoided or if signs of liver or renal toxicities occur while using T.

   • Selon Kadir FA (2011)

     Extrait This study was conducted to determine the effect of ethanolic extract of the dried stems of Tinospora crispa in a male rat model of hepatic fibrosis caused by the hepatotoxin, thioacetamide. To assess the effectivity of extract, against thioacetamide, the activity of aminotransferases (alanine aminotransferase, aspartate aminotransferase), alkaline phosphatase (AP); & bilirubin were measured, together with morphological & histopathological indices in the liver of healthy & thioacetamide-treated rats.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.