Trigonella foenum (Fenugreek) : medicinal properties in alcoholic extraction

Trigonella foenum (Fenugreek, Fenugrec) — family Fabacées.

Scientific synonyms : Foenum-graecum officinale, var Tibetanum-Alef, Trigonella tibetana-(A)-Vass..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 157 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type 1 diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gupta M (2018)

     Excerpt Alloxan (dissolved in 0.1 M citrate buffer (pH = 4.5); intraperitoneally injected @ 130 mg/kg body weight) induced type I diabetic rats were treated with individual & combined doses of ethanol extracts of CQ & TFG for consecutive 30 days @ 250 & 500 mg per kg body weight, orally. CQ & TFG combination therapy showed a marked improvement in bone microarchitecture & can be given together as a potential alternative medicine to insulin for prevention of type I diabetes induced osteopathy.

   • According to Bafadam S (2020)

     Excerpt Bafadam S et al, Trigonella foenum-graceum seed (Fenugreek) hydroalcoholic extract improved the oxidative stress status in a rat model of diabetes-induced memory impairment, Horm Mol Biol Invest, 2020-Abstrac: The antidiabetic & antioxidant effects of Trigonella foenum-graceum have been suggested. foenum-graceum seed prevented memory deficits resulting from diabetes.

   • According to Yadav MM (2009)

     Excerpt In present study, we investigated hypoglycemic & antihyperglycemic potential of five extracts (water, ethanol, methanol, hexane, & chloroform) of four plants (i.e., seeds of Eugenia jambolana, fruits of Momordica charantia, leaves of Gymnema sylvestre, & seeds of Trigonella foenum graecum) alone and/or in combination with glimepiride in rats. The combination of most active extracts (200 mg/kg BW) & lower dose of glimepiride (5 mg/kg BW) showed safer & potent hypoglycemic as well as antihyperglycemic activities without creating severe hypoglycemia in normal rats, while higher doses (200 mg/kg bw of most active extracts, & 10 & 20 mg/kg bw of glimepiride) were generated lethal hypoglycemia in normal rats.

   • According to Abdel-Barry JA (1997)

     Excerpt The aqueous & alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. & 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal & alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed.

   • According to Singh P (2014)

     Excerpt The plant Trigonella foenum-graceum (TFG) is used as antidiabetic & diuretic.

2. 2

   Memory impairment associated with diabetes

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bafadam S (2020)

     Excerpt Bafadam S et al, Trigonella foenum-graceum seed (Fenugreek) hydroalcoholic extract improved the oxidative stress status in a rat model of diabetes-induced memory impairment, Horm Mol Biol Invest, 2020-Abstrac: The antidiabetic & antioxidant effects of Trigonella foenum-graceum have been suggested. The effects of hydroalcoholic extract of the plant seeds & metformin against the diabetes-induced memory impairment were investigated.

   • According to Yadav MM (2009)

     Excerpt In present study, we investigated hypoglycemic & antihyperglycemic potential of five extracts (water, ethanol, methanol, hexane, & chloroform) of four plants (i.e., seeds of Eugenia jambolana, fruits of Momordica charantia, leaves of Gymnema sylvestre, & seeds of Trigonella foenum graecum) alone and/or in combination with glimepiride in rats. The combination of most active extracts (200 mg/kg BW) & lower dose of glimepiride (5 mg/kg BW) showed safer & potent hypoglycemic as well as antihyperglycemic activities without creating severe hypoglycemia in normal rats, while higher doses (200 mg/kg bw of most active extracts, & 10 & 20 mg/kg bw of glimepiride) were generated lethal hypoglycemia in normal rats.

   • According to Abdel-Barry JA (1997)

     Excerpt The aqueous & alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. & 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal & alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed.

   • According to Gupta M (2018)

     Excerpt Alloxan (dissolved in 0.1 M citrate buffer (pH = 4.5); intraperitoneally injected @ 130 mg/kg body weight) induced type I diabetic rats were treated with individual & combined doses of ethanol extracts of CQ & TFG for consecutive 30 days @ 250 & 500 mg per kg body weight, orally. CQ & TFG combination therapy showed a marked improvement in bone microarchitecture & can be given together as a potential alternative medicine to insulin for prevention of type I diabetes induced osteopathy.

   • According to Singh P (2014)

     Excerpt The plant Trigonella foenum-graceum (TFG) is used as antidiabetic & diuretic.

3. 3

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bafadam S (2020)

     Excerpt Bafadam S et al, Trigonella foenum-graceum seed (Fenugreek) hydroalcoholic extract improved the oxidative stress status in a rat model of diabetes-induced memory impairment, Horm Mol Biol Invest, 2020-Abstrac: The antidiabetic & antioxidant effects of Trigonella foenum-graceum have been suggested. foenum-graceum seed prevented memory deficits resulting from diabetes.

   • According to Yadav MM (2009)

     Excerpt In present study, we investigated hypoglycemic & antihyperglycemic potential of five extracts (water, ethanol, methanol, hexane, & chloroform) of four plants (i.e., seeds of Eugenia jambolana, fruits of Momordica charantia, leaves of Gymnema sylvestre, & seeds of Trigonella foenum graecum) alone and/or in combination with glimepiride in rats. The combination of most active extracts (200 mg/kg BW) & lower dose of glimepiride (5 mg/kg BW) showed safer & potent hypoglycemic as well as antihyperglycemic activities without creating severe hypoglycemia in normal rats, while higher doses (200 mg/kg bw of most active extracts, & 10 & 20 mg/kg bw of glimepiride) were generated lethal hypoglycemia in normal rats.

   • According to Abdel-Barry JA (1997)

     Excerpt The aqueous & alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. & 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal & alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed.

   • According to Gupta M (2018)

     Excerpt Alloxan (dissolved in 0.1 M citrate buffer (pH = 4.5); intraperitoneally injected @ 130 mg/kg body weight) induced type I diabetic rats were treated with individual & combined doses of ethanol extracts of CQ & TFG for consecutive 30 days @ 250 & 500 mg per kg body weight, orally. CQ & TFG combination therapy showed a marked improvement in bone microarchitecture & can be given together as a potential alternative medicine to insulin for prevention of type I diabetes induced osteopathy.

   • According to Singh P (2014)

     Excerpt The plant Trigonella foenum-graceum (TFG) is used as antidiabetic & diuretic.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.