Uncaria guianensis (Cat scratcher) : medicinal properties in alcoholic extraction

Uncaria guianensis (Cat scratcher, Grif-chat, Griffe-à-chat) — family Rubiacées.

Scientific synonyms : Nauclea aculeata (Willd.) Willd., N guianensis (Aubl.) Poir., Ourouparia guianensis Aubl. Uncaria aculeata Willd. U spinosa Raeusch.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 21 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rahmawati N (2023)

     Excerpt This study aims to determine the cytotoxic effect of ethanolic extract from the leaves & stem bark of Uncaria Spp on T47D breast cancer cells. The ethanolic extract of U nervosa leaves had a strong cytotoxic effect on T47D breast cancer cells, which was 64.42 µg/mL.

   • According to Urdanibia I (2013)

     Excerpt Uncaria guianensis (Aublet) Gmel (Rubiaceae) is a medicinal plant from the jungles of South & Central America, used to treat cancer, arthritis, diabetes, & inflammation. Materials & methods: Bio-guided fractionation of a hydroethanolic extract of UG was performed, evaluating the fractions & subfractions for their effect on inflammatory mediators, tumour necrosis factor alpha (TNF-α), interleukin 6 (IL-6) & prostaglandin E2 (PGE2) by ELISA & nitric oxide (NO) by the Griess reaction in cultured supernatant from RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS).

   • According to Paixão D (2021)

     Excerpt The Amazonian Rubiaceae species Uncaria guianensis (UG) is locally used as anti-inflammatory, antitumor, antidiabetic, anti-ulcers, & others.

2. 2

   Inflammation: osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Carvalho MC (2006)

     Excerpt Carvalho MC et al, Investigations on the anti-inflammatory & anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. We investigated the anti-inflammatory & antiallergic properties of an ethanolic extract of UG leaves, containing alkaloids, flavonoids & phenol carboxylic acids, as revealed by thin layer chromatography (TLC).

   • According to Miller (2004)

     Excerpt Cartilage degradation, a hallmark of both rheumatoid arthritis & osteoarthritis, contributes to the dysmobility, pain & compromised quality of life associated with these conditions. Vincaria, an alkaloid depleted aqueous extract of cat’s claw (Uncaria guianensis) was studied in combination with SierraSil (final concentra- tions of 2.5, 5 & 10 ng/ml).

   • According to Urdanibia I (2013)

     Excerpt Uncaria guianensis (Aublet) Gmel (Rubiaceae) is a medicinal plant from the jungles of South & Central America, used to treat cancer, arthritis, diabetes, & inflammation. The effect of UG on the inflammatory response in vivo was assessed in BALB/c mice stimulated with LPS, on rat paw oedema induced by carrageenan, & on tumour growth & lung metastasis in BALB/c mice inoculated with 4T1 mammary tumour cells.

   • According to Piscoya J (2001)

     Excerpt The purpose of this investigation was to evaluate the ability of cat's claw, an Amazonian medicinal plant, to treat osteoarthritis of the knee, collect safety & tolerance information & compare the antioxidant, & anti-inflammatory actions of Uncaria guianensis & Uncaria tomentosa in vitro. Materials & methods: Forty-five patients with osteoarthritis of the knee were recruited, 30 were treated with freeze-dried U guianensis, & 15 with placebo.

   • According to Da Silva Zanetti L (2020)

     Excerpt Uncaria guianensis (Aubl.) J. (“cat’s claw”, Rubiaceae) is a plant with potential to treat asthma because of its anti-inflammatory & antioxidant activities.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Carvalho MC (2006)

     Excerpt Carvalho MC et al, Investigations on the anti-inflammatory & anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. We investigated the anti-inflammatory & antiallergic properties of an ethanolic extract of UG leaves, containing alkaloids, flavonoids & phenol carboxylic acids, as revealed by thin layer chromatography (TLC).

   • According to Miller (2004)

     Excerpt Cartilage degradation, a hallmark of both rheumatoid arthritis & osteoarthritis, contributes to the dysmobility, pain & compromised quality of life associated with these conditions. Vincaria, an alkaloid depleted aqueous extract of cat’s claw (Uncaria guianensis) was studied in combination with SierraSil (final concentra- tions of 2.5, 5 & 10 ng/ml).

   • According to Piscoya J (2001)

     Excerpt The purpose of this investigation was to evaluate the ability of cat's claw, an Amazonian medicinal plant, to treat osteoarthritis of the knee, collect safety & tolerance information & compare the antioxidant, & anti-inflammatory actions of Uncaria guianensis & Uncaria tomentosa in vitro. Materials & methods: Forty-five patients with osteoarthritis of the knee were recruited, 30 were treated with freeze-dried U guianensis, & 15 with placebo.

   • According to Urdanibia I (2013)

     Excerpt Uncaria guianensis (Aublet) Gmel (Rubiaceae) is a medicinal plant from the jungles of South & Central America, used to treat cancer, arthritis, diabetes, & inflammation. The effect of UG on the inflammatory response in vivo was assessed in BALB/c mice stimulated with LPS, on rat paw oedema induced by carrageenan, & on tumour growth & lung metastasis in BALB/c mice inoculated with 4T1 mammary tumour cells.

   • According to Da Silva Zanetti L (2020)

     Excerpt Uncaria guianensis (Aubl.) J. (“cat’s claw”, Rubiaceae) is a plant with potential to treat asthma because of its anti-inflammatory & antioxidant activities.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.