Urena lobata (Gran Maho-Kouzen) : medicinal properties in alcoholic extraction

Urena lobata (Gran Maho-Kouzen, Kouzen-wouj, Kouzen Maho, Grand Mahaut-cousin, Red cousin, Cousin-Mahaut, Cousin rouge) — family Malvacées.

Scientific synonyms : Urena americana-L. f, U grandiflora-DC, U. Lobata-Vell, U. lobata-L, var. americana- (L.f)-Gürke..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 49 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Purnomo Y (2015)

     Excerpt Urena lobata is a plant which has been used to cure T2DM empirically but the inhibitory activity on DPP-IV has not been tested. Both of water & ethanolic extract from UL decrease DPP-IV level & blood glucose AUC compared to control group (p<0.05) whereas insulin level & GLP-1 are increased (p<0.05).

   • According to Yudi P (2015)

     Excerpt To evaluate the antidiabetic potential of leaf extract from Urena lobata (U. lobata showed stronger DPP-IV inhibitor activity than water extract with the IC50 values of 1 654.64 & 6 489.88 μg/mL, respectively.

   • According to Islam H (2015)

     Excerpt In oral glucose tolerance tests with methanolic extract of Urena lobata leaves (MEUL), the extract significantly & dose-dependently reduced blood glucose concentrations in glucose-loaded mice. In comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg, reduced blood glucose level by 61.2%.

   • According to OMONKHUA AA (2011)

     Excerpt Urena lobata is one of the medicinal plants used to treat diabetes in Nigeria. Its hypoglycaemic & anti- diabetic activities have been demonstrated.

   • According to Onoagbe IO (2010)

     Excerpt Onoagbe IO et al, A study of the Anti-diabetic effects of Urena lobata & Sphenostylis stenocarpa in streptozotocin-induced diabetic rats, Eur J Sci Res, 43 (1) (2010), 6-14.

2. 2

   Cancer: adjuvant treatment for squamous cell carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pieme CA (2012)

     Excerpt Pieme CA et al, In vitro antiproliferative & anti-oxidant activities of methanol extracts of Urena lobata & Viscum album against breast cancer cell lines Toxicol & Environ Chem, 2012-DOI: 10.1080/02772248.2012.674135,.

   • According to MAKANBILA MC (2011)

     Excerpt Thirty-three extracts were obtained in 3 different solvents (Water, Ethanol, DCM) from these ten plants selected after an ethnobotanic survey in the region of the Pool (Congo Brazzaville): Leonotis nepetaefolia (Lamiaceae), Manotes pruinosa (Connaraceae), Spilanthes uliginosa (Asteraceae), Hymenocardia ulmoides (Euphorbiaceae), Celosia trigyna (Amaranthaceae), Cogniauxia podolaena (Cucurbitaceae), Brillantaisia patula (Acanthaceae), Urena lobata (Malvaceae), Mitracarpus scaber (Rubiaceae), Triumfetta rhomboidea (Tiliaceae). The cytotoxicity of all the extracts was tested on KB (Human epidermoid Carcinoma) & Vero (African green monkey kidney) cell lines with Taxotere as positive control.

   • According to Author (2015)

     Excerpt The leaves of Urena lobata growing along the sides of busy roads of Oluku, Agbor & Sapele in Benin City were studied vis-à-vis those growing in forest areas of Ebvomodu, Eyaen & Ebvoneka villages in the outskirt of Benin City for the activity of air pollution. The epidermal cell walls of leaves of the polluted and non-polluted populations of this species were sinuous in both leaf surfaces and comprised of diacytic stomata.

   • According to Oladele G (2010)

     Excerpt The rats treated with Hyptis suaveolens also showed a significant decrease (p<0.05) in headless tail which may be of significant effect to their fertility, while the rats treated with U lobata extract showed a significant increase (p<0.05) in headless tail sperm cell abnormality,. The plants Hyptis suaveolens, Cleome viscosa & Urena lobata are herbs commonly found growing in pasture & also used as medicinal plant in Nigeria.

3. 3

   Hyperalgesia, pain

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Islam MT (2012)

     Excerpt lobata produced significant (p<0.05) pain relieving activity (number of writhing 32) at 500 mg/kg body weight as compared to standard diclofenac-Na. From this view point two Bangladeshi plants, Uraria lagopodies DC & Urena lobata have been evaluated for their possible pharmacological activities.

   • According to Islam H (2015)

     Excerpt In oral glucose tolerance tests with methanolic extract of Urena lobata leaves (MEUL), the extract significantly & dose-dependently reduced blood glucose concentrations in glucose-loaded mice. In analgesic activity tests with acetic acid induced pain model mice, the extract at the afore-mentioned four doses, significantly and dose-dependently reduced acetic acid induced abdominal constrictions in mice by 18.5, 22.2, 40.7, & 63.0% versus the 48.1 & 63.0% reductions obtained with a standard analgesic drug, aspirin, administered respectively, at doses of 200 & 400 mg per kg.

   • According to MAKANBILA MC (2011)

     Excerpt Thirty-three extracts were obtained in 3 different solvents (Water, Ethanol, DCM) from these ten plants selected after an ethnobotanic survey in the region of the Pool (Congo Brazzaville): Leonotis nepetaefolia (Lamiaceae), Manotes pruinosa (Connaraceae), Spilanthes uliginosa (Asteraceae), Hymenocardia ulmoides (Euphorbiaceae), Celosia trigyna (Amaranthaceae), Cogniauxia podolaena (Cucurbitaceae), Brillantaisia patula (Acanthaceae), Urena lobata (Malvaceae), Mitracarpus scaber (Rubiaceae), Triumfetta rhomboidea (Tiliaceae). The aim of this study was to assess ten plants from the Congolese Pharmacopeia for their analgesic activity as well as their cytotoxicity, in order to validate their traditional use.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.