Vanilla planifolia (Vanniy) : medicinal properties in alcoholic extraction

Vanilla planifolia (Vanniy, vanilla, vanille) — family Orchidacées.

Scientific synonyms : Myrobroma fragrans-Salisb., Notylia planifolia (Andrews) Conz., N sativa (Schiede) Conz., N sylvestris (Schiede) Conz. Vanilla aromatica auct. non Sw., Vanilla bampsiana Geerinck, Vanilla domestica auct. non (L.) Druce, V fragrans auct. non Ames, V planifolia Andrews, 1808 var. planifolia, V planifolia var. sylvestris (Schiede) C, V planifolia Jacks.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 224 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for TEMOZOLOMIDE-resistant glioblastoma multiforme

   Plant part used: Shaft.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vijaybabu K (2019)

     Excerpt The aim of the present study is to reveal the antiproliferative property of vanilla leaf extract against A431 cells. This study revealed the cancer suppression capability of vanilla leaf extract in skin cancer cell lines,.

   • According to Ho K (2009)

     Excerpt Methods: Hence, this study investigated the cytolytic & cytostatic properties of vanillin against HT-29, a human colorectal cancer cell line. Conclusion: Cytolytic & cytostatic effects shown by vanillin showed that it could be a useful colorectal cancer preventive agent.

   • According to Jantaree P (2017)

     Excerpt Here, we evaluated the antimetastatic potential of the food additive divanillin, the homodimer of vanillin, & their structurally related compounds, apocynin & diapocynin, in hepatocellular carcinoma cells. The spread of cancer cells to distant organs, in a process called metastasis, is the main factor that contributes to most death in cancer patients.

   • According to Naz H (2018)

     Excerpt Vanillin is a natural compound, a primary component of the extract of the vanilla bean which possesses varieties of pharmacological features including anti-oxidant, anti-inflammatory, anti-bacterial & anti-tumor. We explored the utility of vanillin as anti-cancer agent and found that it inhibits the proliferation of human hepatocyte carcinoma (HepG2) & neuroblastoma (SH-SY5Y) cells in a dose-dependent manner.

   • According to LI G (2021)

     Excerpt A natural product library was screened, & it was found that vanillin, also known as 4-hydroxy-3-methoxybenzaldehyde, a plant secondary metabolite found in several essential plant oils, mainly Vanilla planifolia, Vanilla tahitensis, & Vanilla pompon, may be a promising anticancer compound targeted to NNMT. Considering that vanillin is an important flavor & aromatic component used in foods worldwide, vanillin is deemed to be a promising anticancer candidate by inhibiting NNMT & may attenuate NNMT-induced resistance to 5-Fu in human CRC therapy with few side effects.

2. 2

   Oral microbial infection: Staphylococcus aureus, Streptococcus mutans, and Enterococcus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kamath AK (2022)

     Excerpt Results: The ethanolic extracts of VP on the agar plates showed considerable anti-microbial activity in both the test methods against Staphylococcus aureus, Streptococcus mutans, & Enterococcus. Conclusions: This experimental study presents a medicinal plant, an orchid Vanilla planifolia, which demonstrates the presence of essential anti-microbial agents in it, making it a potent, potential dental biomaterial with a positive & benefitting effect on the oral micro-environment,.

3. 3

   Pain, hyperalgesia

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SARAK A (2023)

     Excerpt Objective: To evaluate the analgesic activity of ethanolic extract of Vanilla planifolia seeds. Vanilla planifolia (VP) as per literature has analgesic activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.