Vernonia cinerea (Zèb-lasand) : medicinal properties in alcoholic extraction

Vernonia cinerea (Zèb-lasand, Ti-zèb-a-fè-savann, Purple rabbit-food, Ash-grass, Small savannah ironweed, Purple rabbit food., Manjé-lapen violèt, herbe-à cendre, Petite herbe-à-fer à savane, Manger-à-lapin violet.) — family Asteracées.

Scientific synonyms : Cacalia Cinerea-(L)-Ktze, Conyza cinerea-L, C. Chinensis-L, Cyanthillium cinereum-(L)-H.Rob, Senecioides cinerea-(L)-Q. Ktze, Vernonia kroneana-M..

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 18 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 91 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Choudhary S (2013)

     Excerpt The present study was carried out to isolate & identify the potent antidiabetic compounds from whole plant of Vernonia cinerea. The standard drug Glibenclamide (10mg/kg) also produced significant (p<0.05) reduction in blood glucose level against alloxan-induced diabetic mice.

   • According to Shahdaat Bin Sayeed M (2013)

     Excerpt Shahdaat Bin Sayeed M et al, A Randomized, Placebo-Controlled, Crossover Study of an Herbal Preparation Containing Vernonia cinerea in the Treatment of Type 2 Diabetes, The J of Alter & Comp Med, 2013, 19(9): 767-771.

   • According to Chatterjee P (2014)

     Excerpt The different parts of Vernonia cinerea Less has been possess Hypoglycemic and antidiabetic activity, anti-pyretic activity, antibacterial activity, diuretic and antidiuretic activity, anti-inflammatory activity, free radicals and No scavenging activity, Analgesic activity. The alcoholic extracts of aerial parts of Vernonia cinerea has been examined for the effect of petroleum ether, ethyl acetate on cisplatin-induced nephrotoxicity at a dose of 6mg/kg, i.p.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to LEELAPRAKASH G (2011)

     Excerpt In the present study, we investigated the protective effect of Vernonia cinerea (F. There were general statistically significant losses in activities of SOD, CAT, GPx, GSH, Vit-C, & an increase in MDA in the liver of CCl4-treated group compared with the control group.

   • According to Iwalokun BA (2006)

     Excerpt Iwalokun BA et al Hepatoprotective & antioxidant activities of Vernonia amygdalina on acetaminophen induce hepatic damage in mice.

   • According to Gokilaveni C (2006)

     Excerpt Gokilaveni C et al, Ameliorative role of Vernonia cinerea in carbon tetrachloride induced hepatic dysfunction in rats, Ancient Science of Life, 25 :1-5, 2006.

   • According to Hernandez RCE (n.d.)

     Excerpt In previous studies, Vernonia cinerea was proven for its medicinal use as an anti-inflammatory, diuretic, hepatoprotective, & nephroprotective. Based on the results, there is sufficient evidence to suggest that the ethanolic leaf extract of Vernonia cinerea exhibits no angiogenic & genotoxic properties, but exhibits mutagenic properties.

   • According to ARUNA G (2012)

     Excerpt The present investigation was carried out to evaluate the safety of ethanol extract of Vernonia cinerea (EVC) whole plant by determining its potential toxicity after acute & chronic administration in rats. In view of the dose of V cinerea consumed in traditional medicine, there is a wide margin of safety for the therapeutic use of the ethanol extract of V cinerea whole plant.

3. 3

   Cancer: adjuvant treatment for metastatic melanoma

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Youn A (2012)

     Excerpt Bioassay-guided fractionation of the hexane extract from the flowers of Vernonia cinerea (Asteraceae) led to the isolation of a new sesquiterpene lactone, 8α-hydroxy-hirsutinolide (2), & a new naturally occurring derivative, 8α-hydroxyl-1-O-methylhirsutinolide (3), along with seven known compounds (1 & 4-9). The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor alpha (TNF-α)-induced NF-κB activity.

   • According to SANGHEETA T (2075)

     Excerpt The entire animals were evaluated for cancer cell count, Haematological parameters, serum enzyme & lipid profile, Body weight & Median Survival Time (MST) were compared with the same parameters of standard by collecting blood from retro orbital blood vessel of mice. The aim of the present study is to evaluate the effect of various extracts of Vernonia cinerea against Dalton's Ascitic Lymphoma (DAL) in Swiss Albino mice.

   • According to Pratheeshkumar P (2011)

     Excerpt There was 89.39% inhibition of lung tumor nodule formation & 88.51% increase in the life span of metastatic tumor-bearing animals. These results indicate that V-A could inhibit the metastatic progression of B16F-10 melanoma cells in mice.

   • According to Appadath Beeran A (2014)

     Excerpt MATERIALS & METHODS: Cytotoxicity of the ethanolic extract of VC (VC-ET), petroleum ether fraction (VC-PET), dichlorométhane fraction (VC-DCM), N-butyl alcohol fraction (VC-BT), and rest fraction (VC-R) was evaluated in cervical carcinoma (HeLa), lung adenocarcinoma (A549), breast cancer (MCF-7), & colon carcinoma (Caco-2) cells using Sulforhodamine B (SRB) assay. Interestingly, VC-DCM significantly inhibited functional activity of MDR transporters (ABC-B1 & ABC-G2), enhanced DNR-uptake in cancer cells, and sensitized cancer cells towards chemotherapeutic drug-mediated cytotoxicity, thus indicating the ability of VC-DCM to reverse MDR in cancer and enhance the cytotoxic effects of anticancer drugs.

   • According to Pratheeshkumar P (n.d.)

     Excerpt Administration of vernolide-A, enhanced natural killer (NK) cell activity, antibody-dependent cellular cytotoxicity (ADCC), & antibody-dependent complement-mediated cytotoxicity (ACC) & the activity was observed in treated group much earlier compared with the metastatic tumor-bearing control. Administration of vernolide-A significantly enhanced the production of interleukin (IL)-2 & interferon-gamma (IFN-γ) in metastatic tumor-bearing animals.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.