Vernonia cinerea (Zèb-lasand) : vertus médicinales en extraction alcoolique

Vernonia cinerea (Zèb-lasand, Ti-zèb-a-fè-savann, Manjé-lapen violèt, herbe-à cendre, Petite herbe-à-fer à savane, Manger-à-lapin violet.) — famille Asteracées.

Synonymes scientifiques : Cacalia Cinerea-(L)-Ktze, Conyza cinerea-L, C. Chinensis-L, Cyanthillium cinereum-(L)-H.Rob, Senecioides cinerea-(L)-Q. Ktze, Vernonia kroneana-M..

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 18 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 91 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Plante entière. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Choudhary S (2013)

     Extrait The present study was carried out to isolate & identify the potent antidiabetic compounds from whole plant of Vernonia cinerea. The standard drug Glibenclamide (10mg/kg) also produced significant (p<0.05) reduction in blood glucose level against alloxan-induced diabetic mice.

   • Selon Shahdaat Bin Sayeed M (2013)

     Extrait Shahdaat Bin Sayeed M et al, A Randomized, Placebo-Controlled, Crossover Study of an Herbal Preparation Containing Vernonia cinerea in the Treatment of Type 2 Diabetes, The J of Alter & Comp Med, 2013, 19(9): 767-771.

   • Selon Chatterjee P (2014)

     Extrait The different parts of Vernonia cinerea Less has been possess Hypoglycemic and antidiabetic activity, anti-pyretic activity, antibacterial activity, diuretic and antidiuretic activity, anti-inflammatory activity, free radicals and No scavenging activity, Analgesic activity. The alcoholic extracts of aerial parts of Vernonia cinerea has been examined for the effect of petroleum ether, ethyl acetate on cisplatin-induced nephrotoxicity at a dose of 6mg/kg, i.p.

2. 2

   Hépatite, cirrhose, stéatose hépatique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon LEELAPRAKASH G (2011)

     Extrait In the present study, we investigated the protective effect of Vernonia cinerea (F. There were general statistically significant losses in activities of SOD, CAT, GPx, GSH, Vit-C, & an increase in MDA in the liver of CCl4-treated group compared with the control group.

   • Selon Iwalokun BA (2006)

     Extrait Iwalokun BA et al Hepatoprotective & antioxidant activities of Vernonia amygdalina on acetaminophen induce hepatic damage in mice.

   • Selon Gokilaveni C (2006)

     Extrait Gokilaveni C et al, Ameliorative role of Vernonia cinerea in carbon tetrachloride induced hepatic dysfunction in rats, Ancient Science of Life, 25 :1-5, 2006.

   • Selon Hernandez RCE (s.d.)

     Extrait In previous studies, Vernonia cinerea was proven for its medicinal use as an anti-inflammatory, diuretic, hepatoprotective, & nephroprotective. Based on the results, there is sufficient evidence to suggest that the ethanolic leaf extract of Vernonia cinerea exhibits no angiogenic & genotoxic properties, but exhibits mutagenic properties.

   • Selon ARUNA G (2012)

     Extrait The present investigation was carried out to evaluate the safety of ethanol extract of Vernonia cinerea (EVC) whole plant by determining its potential toxicity after acute & chronic administration in rats. In view of the dose of V cinerea consumed in traditional medicine, there is a wide margin of safety for the therapeutic use of the ethanol extract of V cinerea whole plant.

3. 3

   Cancer : traitement adjuvant du mélanome métastasé

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Youn A (2012)

     Extrait Bioassay-guided fractionation of the hexane extract from the flowers of Vernonia cinerea (Asteraceae) led to the isolation of a new sesquiterpene lactone, 8α-hydroxy-hirsutinolide (2), & a new naturally occurring derivative, 8α-hydroxyl-1-O-methylhirsutinolide (3), along with seven known compounds (1 & 4-9). The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor alpha (TNF-α)-induced NF-κB activity.

   • Selon SANGHEETA T (2075)

     Extrait The entire animals were evaluated for cancer cell count, Haematological parameters, serum enzyme & lipid profile, Body weight & Median Survival Time (MST) were compared with the same parameters of standard by collecting blood from retro orbital blood vessel of mice. The aim of the present study is to evaluate the effect of various extracts of Vernonia cinerea against Dalton's Ascitic Lymphoma (DAL) in Swiss Albino mice.

   • Selon Pratheeshkumar P (2011)

     Extrait Vernolide-A was administered in three different modalities such as simultaneously with tumor, prophylactic to tumor & after tumor development. There was 89.39% inhibition of lung tumor nodule formation & 88.51% increase in the life span of metastatic tumor-bearing animals.

   • Selon Appadath Beeran A (2014)

     Extrait MATERIALS & METHODS: Cytotoxicity of the ethanolic extract of VC (VC-ET), petroleum ether fraction (VC-PET), dichlorométhane fraction (VC-DCM), N-butyl alcohol fraction (VC-BT), and rest fraction (VC-R) was evaluated in cervical carcinoma (HeLa), lung adenocarcinoma (A549), breast cancer (MCF-7), & colon carcinoma (Caco-2) cells using Sulforhodamine B (SRB) assay. Interestingly, VC-DCM significantly inhibited functional activity of MDR transporters (ABC-B1 & ABC-G2), enhanced DNR-uptake in cancer cells, and sensitized cancer cells towards chemotherapeutic drug-mediated cytotoxicity, thus indicating the ability of VC-DCM to reverse MDR in cancer and enhance the cytotoxic effects of anticancer drugs.

   • Selon Pratheeshkumar P (s.d.)

     Extrait Administration of vernolide-A, enhanced natural killer (NK) cell activity, antibody-dependent cellular cytotoxicity (ADCC), & antibody-dependent complement-mediated cytotoxicity (ACC) & the activity was observed in treated group much earlier compared with the metastatic tumor-bearing control. In addition, vernolide-A significantly down-regulated the serum levels of proinflammatory cytokines such as IL-1β, IL-6, tumor necrosis factor-alpha (TNF-α) & granulocyte-macrophage colony-stimulating factor (GM-CSF) during metastasis.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.