Vitex negundo (Midjé-blé) : medicinal properties in alcoholic extraction

Vitex negundo (Midjé-blé, Blue lily of the valley, Muguet bleu) — family Verbenacées.

Scientific synonyms : Vitex agnus-castus auct. Non L, V paniculata auct non Lam.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 32 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 198 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: liver, breast, prostate and uterine carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kadir FA (2013)

     Excerpt Hepatocellular carcinoma is a common type of tumour worldwide with a high mortality rate & with low response to current cytotoxic & chemotherapeutic drugs. The prediction of activity spectra for the substances (PASS) software, which predicted that more than 300 pharmacological effects, biological & biochemical mechanisms based on the structural formula of the substance was efficiently used in this study to reveal new multitalented actions for Vitex negundo (VN) constituents.

   • According to Author (2005)

     Excerpt Tandon VR, Medicinal Uses & Biologic Activities of Vitex negundo, Nat Prod Radiance, 2005-Abstrct: Vitex negundo Linn. is credited with innumerable medicinal activities like analgesic, antiinflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc.

   • According to Tandon VR (2008)

     Excerpt Hepatoprotective (HP) activity of Vitex negundo (VN) leaf ethanolic extract was investigated against hepatotoxicity (HT) produced by administering a combination of three anti-tubercular drugs isoniazid (INH)-7.5 mg/kg, rifampin(RMP)-10 mg/kg & pyrazinamide (PZA)-35 mg/kg for 35 35 days by oral route in rats. Histology of the liver section of the animals treated with the VN leaf ethanolic extract in the doses of 250 & 500 mg/kg further confirms the HP activity,.

   • According to Mahalakshmi R (2010)

     Excerpt The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. These results suggest that leaves of VN having the hepatoprotective activity, which support the hepatic cells protection.

   • According to Zheng CJ (2010)

     Excerpt The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Zahura Falguni M (2017)

     Excerpt Ethyl alcohol extract of VN leaves in doses of 200 & 300 mgkg-1 body weights was daily administered orally by gavages to mice for 21 days to evaluate their antihyperglycemic & antihyperlipidemic effects on normal & streptozotocin-induced diabetic mice. The study validates scientifically the widely claimed use of VN leaves as an ethnomedicine to treat diabetes mellitus,.

   • According to Raja P (2012)

     Excerpt Aqueous and ethanol leaf extract of Vitex negundo was studied for its antidiabetic activity using alloxan induced diabetic model in rats. The aqueous extract showed (P<0.01) significant activity than the ethanol extract at the tested dose level, which were comparable to glibenclamide, a standard antidiabetic drug,.

   • According to Manikandan R (2011)

     Excerpt The aim of this study is to investigate the mechanism of an action of compound isolated from Vitex negundo in streptozotocin-induced diabetic mice. To understand the probable mechanism of action of 1, 2 di-substituted idopyranose, we analyzed proinflammatory inducible nitric oxide synthase (iNOS) & nuclear factor-kappa B (NF-κB) expression by immunohistochemistry & the results showed an increased iNOS and NF-κB levels in streptozotocin-induced diabetic liver, kidney and pancreas.

   • According to Gautam K (2013)

     Excerpt Aim: The objective of the present study was to evaluate the alpha amylase inhibitory activity of flavonoids extracts of different parts of Vitex negundo Linn & Andrographis paniculata Nees. One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose.

   • According to Pankaj M (2013)

     Excerpt Pankaj M et al, Phytochemical Investigation & Hypoglycemic effects of Vitex negundo.

3. 3

   Cirrhosis, hepatitis, liver fibrosis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2005)

     Excerpt Tandon VR, Medicinal Uses & Biologic Activities of Vitex negundo, Nat Prod Radiance, 2005-Abstrct: Vitex negundo Linn. is credited with innumerable medicinal activities like analgesic, antiinflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc.

   • According to Tandon VR (2008)

     Excerpt Hepatoprotective (HP) activity of Vitex negundo (VN) leaf ethanolic extract was investigated against hepatotoxicity (HT) produced by administering a combination of three anti-tubercular drugs isoniazid (INH)-7.5 mg/kg, rifampin(RMP)-10 mg/kg & pyrazinamide (PZA)-35 mg/kg for 35 35 days by oral route in rats. Histology of the liver section of the animals treated with the VN leaf ethanolic extract in the doses of 250 & 500 mg/kg further confirms the HP activity,.

   • According to Mahalakshmi R (2010)

     Excerpt The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. These results suggest that leaves of VN having the hepatoprotective activity, which support the hepatic cells protection.

   • According to Zheng CJ (2010)

     Excerpt The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn.

   • According to Sharmaa N (2016)

     Excerpt The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from VN against acetaminophen (APAP) & galactosamine (GalN) hepatotoxicity. Microscopic examination of histopathological sections of liver confirmed hepatoprotective potential of SF.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.