Vitex negundo (Midjé-blé) : vertus médicinales en extraction alcoolique

Vitex negundo (Midjé-blé, Muguet bleu) — famille Verbenacées.

Synonymes scientifiques : Vitex agnus-castus auct. Non L, V paniculata auct non Lam.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 32 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 198 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer: carcinome hépatique, mammaire, prostatique & utérin

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Kadir FA (2013)

     Extrait Hepatocellular carcinoma is a common type of tumour worldwide with a high mortality rate & with low response to current cytotoxic & chemotherapeutic drugs. The prediction of activity spectra for the substances (PASS) software, which predicted that more than 300 pharmacological effects, biological & biochemical mechanisms based on the structural formula of the substance was efficiently used in this study to reveal new multitalented actions for Vitex negundo (VN) constituents.

   • Selon Auteur (2005)

     Extrait Tandon VR, Medicinal Uses & Biologic Activities of Vitex negundo, Nat Prod Radiance, 2005-Abstrct: Vitex negundo Linn. is credited with innumerable medicinal activities like analgesic, antiinflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc.

   • Selon Tandon VR (2008)

     Extrait Hepatoprotective (HP) activity of Vitex negundo (VN) leaf ethanolic extract was investigated against hepatotoxicity (HT) produced by administering a combination of three anti-tubercular drugs isoniazid (INH)-7.5 mg/kg, rifampin(RMP)-10 mg/kg & pyrazinamide (PZA)-35 mg/kg for 35 35 days by oral route in rats. Histology of the liver section of the animals treated with the VN leaf ethanolic extract in the doses of 250 & 500 mg/kg further confirms the HP activity,.

   • Selon Mahalakshmi R (2010)

     Extrait The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. These results suggest that leaves of VN having the hepatoprotective activity, which support the hepatic cells protection.

   • Selon Zheng CJ (2010)

     Extrait The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn.

2. 2

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Zahura Falguni M (2017)

     Extrait Ethyl alcohol extract of VN leaves in doses of 200 & 300 mgkg-1 body weights was daily administered orally by gavages to mice for 21 days to evaluate their antihyperglycemic & antihyperlipidemic effects on normal & streptozotocin-induced diabetic mice. The study validates scientifically the widely claimed use of VN leaves as an ethnomedicine to treat diabetes mellitus,.

   • Selon Raja P (2012)

     Extrait Aqueous and ethanol leaf extract of Vitex negundo was studied for its antidiabetic activity using alloxan induced diabetic model in rats. The aqueous extract showed (P<0.01) significant activity than the ethanol extract at the tested dose level, which were comparable to glibenclamide, a standard antidiabetic drug,.

   • Selon Manikandan R (2011)

     Extrait The aim of this study is to investigate the mechanism of an action of compound isolated from Vitex negundo in streptozotocin-induced diabetic mice. To understand the probable mechanism of action of 1, 2 di-substituted idopyranose, we analyzed proinflammatory inducible nitric oxide synthase (iNOS) & nuclear factor-kappa B (NF-κB) expression by immunohistochemistry & the results showed an increased iNOS and NF-κB levels in streptozotocin-induced diabetic liver, kidney and pancreas.

   • Selon Gautam K (2013)

     Extrait Aim: The objective of the present study was to evaluate the alpha amylase inhibitory activity of flavonoids extracts of different parts of Vitex negundo Linn & Andrographis paniculata Nees. One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose.

   • Selon Pankaj M (2013)

     Extrait Pankaj M et al, Phytochemical Investigation & Hypoglycemic effects of Vitex negundo.

3. 3

   Cirrhose, hépatite, fibrose hépatique, stéatose hépatique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Auteur (2005)

     Extrait Tandon VR, Medicinal Uses & Biologic Activities of Vitex negundo, Nat Prod Radiance, 2005-Abstrct: Vitex negundo Linn. is credited with innumerable medicinal activities like analgesic, antiinflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc.

   • Selon Tandon VR (2008)

     Extrait Hepatoprotective (HP) activity of Vitex negundo (VN) leaf ethanolic extract was investigated against hepatotoxicity (HT) produced by administering a combination of three anti-tubercular drugs isoniazid (INH)-7.5 mg/kg, rifampin(RMP)-10 mg/kg & pyrazinamide (PZA)-35 mg/kg for 35 35 days by oral route in rats. Histology of the liver section of the animals treated with the VN leaf ethanolic extract in the doses of 250 & 500 mg/kg further confirms the HP activity,.

   • Selon Mahalakshmi R (2010)

     Extrait The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. These results suggest that leaves of VN having the hepatoprotective activity, which support the hepatic cells protection.

   • Selon Zheng CJ (2010)

     Extrait The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn.

   • Selon Sharmaa N (2016)

     Extrait The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from VN against acetaminophen (APAP) & galactosamine (GalN) hepatotoxicity. Microscopic examination of histopathological sections of liver confirmed hepatoprotective potential of SF.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.