Vitis vinifera (Rézen) : medicinal properties in alcoholic extraction

Vitis vinifera (Rézen, grape, raisin) — family Vitacées.

Scientific synonyms : ---.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 56 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to NERMIEN Z (2016)

     Excerpt This study aim to determine the protective effect of Grape seeds (Vitis vinifera) ethanolic extract against streptozotocin-induced diabetic rats. Also, it can be speculated that Grape seed (Vitis vinifera) ethanolic extract has a hypoglycemic effect possibly related to the phytochemical compounds of Vitis vinifera plant seeds include Gallic acids, Catechin, Ρ-hydroxy Benzoic acid, Vanillin, Ferulic acid, Ρ-Coumaric acid, Euganol , as well as, 5,7- Dihydroxy 4-methoxy isoflavone which can optimize sugar uptake in the liver.

   • According to Margină D (2015)

     Excerpt The results of the present study may be translated into clinical practice & demonstrate that C longa extracts may be effective in both the prevention of diabetes mellitus & in attenuating the development of complications associated with the disease. In the present study, we aimed to obtain & characterize certain extracts from Vitis vinifera L., Aesculus hippocastanum L.

   • According to GIRIBABU N (2015)

     Excerpt Methods : VV seed ethanolic extract (250 & 500 mg/kg/day) or Glibenclamide (600 μg/kg/day) was administered to streptozotocin-induced male diabetic rats for 28 consécutive days. vinifera seeds on carbohydrate metabolizing enzymes and other enzymes of the liver in diabetes is currently unknown.

   • According to KORKMAZ N (2025)

     Excerpt Objective: In this study, the protective potential of grape (Vitis vinifera L.) seed extract (GSE) against the toxic effects of cadmium (Cd) on growth hormone, stress hormones, & thyroid hormones in common carp (Cyprinus carpio L.) was investigated for the first time. Results: Cadmium exposure caused significant hormonal disruptions in common carp, including reductions in growth hormone, insulin-like growth factor 1, thyroid-stimulating hormone, & triiodothyronine levels, along with elevations in cortisol & thyroxine levels during both acute & subchronic exposure periods (P < 0.05).

   • According to Zeytünlüoğlu A (2015)

     Excerpt Results: Among the tested plants Vitis vinifera L., Artemisia dracunculus L., Prunus laurocerasus L., Rubus caesius L. Dipeptidyl peptidase IV (DPP IV) is a serine amino (exo) peptidase which regulates various processes most notably plasma glucose homeostasis by cleaving incretin peptide hormones as glucagon-like peptide-1 (GLP-1) & glucose-dependent insulin releasing polypeptide (GIP).

2. 2

   Cirrhosis, hepatitis, fatty liver disease

   Plant part used: leaf. Mentioned synergistic association: Centella asiatica-plante entière.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Munakarmi S (2023)

     Excerpt Liver injury can be acute or chronic, resulting from a variety of factors, including viral hepatitis, drug overdose, idiosyncratic drug reaction, or toxins, while the progression of pathogenesis in the liver rises due to the involvement of numerous cytokines & growth factor mediators. (VE) & Centella asiatica (CE) are well-known medicinal plants that possess anti-inflammatory & antioxidant properties.

   • According to ORHAN DD (2007)

     Excerpt The hepatoprotective effect of ethanolic extract and its four different fractions (CHCl3, EtOAc, n-BuOH, & remaining water fraction) of Vitis vinifera L. The ethanolic extract was fractionated through successive solvent–solvent extractions & the n-BuOH fraction in 83 mg/kg dose possessed remarkable antioxidant and hepatoprotective activities.

   • According to SHARMA SKR (2012)

     Excerpt The ethanolic extract of the root of Vitis vinifera (Vitaceae) was evaluated for hepatoprotective activity in rats with liver damage induced by carbon tetrachloride. These biochemical observations were supplemented by histopathological examination of liver sections.

   • According to NERMIEN Z (2016)

     Excerpt Also, it can be speculated that Grape seed (Vitis vinifera) ethanolic extract has a hypoglycemic effect possibly related to the phytochemical compounds of Vitis vinifera plant seeds include Gallic acids, Catechin, Ρ-hydroxy Benzoic acid, Vanillin, Ferulic acid, Ρ-Coumaric acid, Euganol , as well as, 5,7- Dihydroxy 4-methoxy isoflavone which can optimize sugar uptake in the liver. This study aim to determine the protective effect of Grape seeds (Vitis vinifera) ethanolic extract against streptozotocin-induced diabetic rats.

   • According to GIRIBABU N (2015)

     Excerpt vinifera seed ethanolic extract was able to prevent the decrease in ICDH, SDH, MDH, and G-6-PDH & the increase in LDH activity levels in liver homogenates. vinifera seeds on carbohydrate metabolizing enzymes and other enzymes of the liver in diabetes is currently unknown.

3. 3

   Cancer: adjuvant treatment for breast cancer

   Plant part used: seed. Mentioned synergistic association: Ixora coccinea-fleur, Piper longum-racine.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Balea SS (2020)

     Excerpt Because grape pomace is a rich source of antioxidant compounds, the purpose of the study was to evaluate the antioxidant, anti-inflammatory, & antiproliferative effects of fresh & fermented grape pomace extracts of two Vitis vinifera L. Thirdly, the antiproliferative properties were evaluated on human lung carcinoma (A549), human breast adenocarcinoma (MDA-MB-231), murine melanoma (B164A5), & keratinocyte (HaCat) cell lines.

   • According to PERIYANAYAGAM P (2013)

     Excerpt To prescreen the in vivo antimitotic & antiproliferative activity of the leaves of Vitis vinifera. vinifera (Vitaceae), Common Grape Vine was selected for phytochemical & pharmacological screening of antimitotic & antiproliferative activity.

   • According to Balea ŞS (2020)

     Excerpt Thirdly, the antiproliferative properties were evaluated on human lung carcinoma (A549), human breast adenocarcinoma (MDA-MB-231), murine melanoma (B164A5), & keratinocyte (HaCat) cell lines. Because grape pomace is a rich source of antioxidant compounds, the purpose of the study was to evaluate the antioxidant, anti-inflammatory, & antiproliferative effects of fresh & fermented grape pomace extracts of two VV varieties Fetească neagră & Pinot noir cultivated in Romania.

   • According to Nelson S.S (2019)

     Excerpt The anticancer potentials of the seed extracts of edible fruits pomegranate (Punica granatum L.), guava (Psidium guajava L.) & grapes (Vitis vinifera L.) were evaluated. Among the selected edible fruit seeds & their different organic solvent extracts, the ethyl acetate extract of P granatum possessed a higher inhibitory effect against lung cancer cell line, compared to other solvent extracts of P guajava & V vinifera fruit seeds, & the IC 50 value was 51.25 ± 1.25 μg/ml, 60.21 ± 1.35 μg/ml & 61.21±1.45μg/ml, respectively.

   • According to Urolagin DK (2018)

     Excerpt Here, we investigated the anti-cancer effects of 3 drug extracts-Vitis vinifera-Grape seeds (GSE), Ixora coccinea flower & Piper longum root extract against breast cancer treatment. The percentage inhibition of V vinifera (10–320 µg/ml), I coccinea (10–320 µg/ml) & P longum (10–320 µg/ml) treatment of cells resulted in 10–90%, 6-53% & 14-90% growth inhibition respectively.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.