Wedelia sphagneticola (Brenbal) : medicinal properties in alcoholic extraction

Wedelia sphagneticola (Brenbal, boyo-tôti, Flè, solèy, Brimbale, Turtle gut, Sunflower, Boyau-à-tortue, Fleur soleil) — family Asteracées.

Scientific synonyms : Acmella spilanthoides Cass., Buphthalmum procumbens Desf., Wedelia trilobata –(L)-Hitchcrenata.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 78 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Buddhhakala N (2020)

     Excerpt The antidiabetic activity was examined by orally administering ST extract of 250 mg/kg body weight to streptozotocin-induced diabetic rats on a daily basis for eight weeks; & the body weight, blood glucose, serum insulin, & lipid profiles were determined. trilobata, METHODS: This research investigates the toxicity and antidiabetic activity of Sphagneticola trilobata flower ethanolic extract in rats.

   • According to Kade IJ (2010)

     Excerpt Kade IJ et al, Aqueous extracts of Sphagneticola trilobata attenuates streptozotocin-induced hyperglycaemia in rat models by modulating oxidative stress parameters Biol & Med, 2010; 2(3):1-13,.

   • According to Schmitz P (n.d.)

     Excerpt Cissus verticillata & Sphagneticola trilobata have been used in Brazilian folk medicine for Diabetes Mellitus treatment, although their pharmacological & toxicological profile has not been clearly established.

   • According to Mizokami SS (2012)

     Excerpt Furthermore, the analgesic effect of 1 was inhibited by l-NAME, ODQ, KT5823, & glibenclamide treatment, demonstrating that such activity also depends on activation of the NO–cyclic GMP–protein kinase G–ATP-sensitive potassium channel signaling pathway, respectively. Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants including Sphagneticola trilobata.

   • According to Chethan J (2014)

     Excerpt Artimisia vulgaris, Eclipta alba, Glossocardia bosvallea, Wedelia chinensis & Wedelia trilobata showed inhibition of α-amylase and α- glucosidase enzymes that are responsible for the breakdown of oligosaccharides into monosaccharides. Antidiabetic & Antihypertensive activity of 10 ethnobotanically known plants of Asteraceae family was investigated using in vitro glucose diffusion, α-amylase, α-glucosidase & Angiotensin I converting enzyme (ACE) inhibition methods.

2. 2

   Inflammation: inflammatory pain

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Masuma R (2021)

     Excerpt The present study was investigated to evaluate the analgesic, anti-inflammatory & antipyretic effect of Wedelia trilobata. Treatment with WT at both the doses reduced pyrexia very highly significantly (p<0.001) in yeast induced antipyretic test.Results from the studies suggested that the WT extract showed potent analgesic, anti-inflammatory & antipyretic effects in various animal models.

   • According to Fucina G (2016)

     Excerpt The aerial parts of Sphagneticola trilobata (L.) Pruski (Asteraceae) are popularly used to treat topical inflammation, but have not been fully investigated. The extent of ear edema induced by applying 20 μL of croton oil (2.5%), arachidonic acid (AA; 2 mg/ear) & decanoylphorbol-13-acetate (TPA; 2.5 mg/ear) in mice was used to evaluate the biological activity of the semisolids, which were applied 30 min before the phlogistic agents.

   • According to Meena AK (2011)

     Excerpt It is an interesting source of potential bioactive molecules, as iridoids compounds, flavonoids, diterpenoids derivatives, phytosteroids, with antioxidant, anti-inflammatory, antimicrobial, Hepatoprotective activity, analgesic & antihistamine ,Anti-implantation, antiasthmatic activities & anticancer activity. This work reviews the pharmacological evidence of extracts of plants from the genus Wedelia, giving an overview of the most studied biological effects & the known phytochemical composition.

   • According to Lang K (2017)

     Excerpt the aim of this work was to investigate the thermostability of herbal derivatives of the aerial parts of Sphagneticola trilobata, a reputed medicinal plant; to biomonitor its oral anti-hyperalgesic effect; & to elucidate the degradation pathways of the major components by UHPLC-ESI-QTOF-MS. These results provide a relevant guide for the extraction process of ST, aimed at preserving the antinociceptive effect.

   • According to Sureshkumar S (2007)

     Excerpt Wedelia trilobata (EEWT), Wedelia biflora (EEWB) & Eclipta alba (EEEA) was evaluated by acetic acid induced writhing method & hot plate assay to assess analgesic activity in mice. The results reflects that analgesic effects & therapeutic efficacy of the extract on animal models which are comparable with those of standard drugs such as Aspirin & Morphine,.

3. 3

   Cancer: adjuvant treatment for myeloid leukaemia and sarcoma

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Murali M (2022)

     Excerpt In addition, the cytotoxic ability of the StZnO-NPs against the HT-29 colon cancer cells & human erythrocytes revealed that the particles were cytotoxic towards HT-29 cells, while insignificant effect against the human erythrocytes. the same the present study was designed to biosynthesize zinc oxide nanoparticles (ZnO-NPs) from the aqueous leaf extract (ALE) of medicinally important plant Sphagneticola trilobata L.

   • According to Mardina V (2020)

     Excerpt The antioxidant and anticancer activities were assessed by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay methods, respectively. In this study, the antioxidant & anticancer properties of the ethyl acetate extract from S.

   • According to Surbaki Juanda B (2021)

     Excerpt The use of plant extracts as a preventive or curative in cases of tumors/cancer has been reported, however there is no reports about the in vivo study for Sphagneticola trilobata plant. This study aims to examine the anticancer effect of the methanol extract of ST leaves using histology observation on Wistar rat (Rattus novergicus) kidney which was induced by 7,12 dimethylbenz [α] anthracene (DMBA).

   • According to Author (2012)

     Excerpt Since WT 4-4 could significantly inhibit the growth of S-180 cell line, in vivo antitumor assay using Sarcoma 180 tumor-bearing BALB/c mice was also carried out. After screening the antitumor activity of water extracts of four Compositae species, Wedelia thlobata was chosen for detailed investigation in this project.

   • According to Zhang B (2023)

     Excerpt All eudesmanolides were evaluated for their anti-proliferative activities against four human tumor cell lines (HepG2, HeLa, SGC-7901, & MCF-7). Twenty-six eudesmanolides including six undescribed compounds were isolated from the flowers of Sphagneticola trilobata (L.) Pruski.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.