Camellia sinensis (Té verde) : propiedades medicinales en extracción alcohólica

Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate, Brain Res, 1124(1) :176-87, 2006-Abstract: The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) & glaucoma. Initial in vitro studies on brain membranes showed that EGCG was approximately 10 times more potent than trolox (vitamin E analogue) at attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SN…

Aqueous extracts of Crinum latifolium (L.) & Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells. Int Immuno-Pharmacol; 1:2143–50. 2001-Abstract: In Vietnamese & Chinese traditional medicine, hot aqueous extract of Crinum latifolium is used because of its antitumor activity. The genus Crinum is thought to possess antiviral & immunostimulative properties. Green & black tea derived from Camellia sinensis have similar qualities. A growing body of evidence suggests that moderate consumption of green & black tea may protect, e.g., against several forms …

Tamoxifen & epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. Anticancer Drugs 2004; 15:889–97.-Abstract: High concentrations of specific catechins [epigallocatechin gallate (EGCG), epigallocatechin (EGC) & epicatechin gallate (ECG)] inhibit the proliferation of many different cancer cell lines. The aim of this work was to determine if low concentrations of catechins with & without 4-hydroxytamoxifen (4-OHT) co-treatment would cause significant cytotoxicity in estrogen receptor-positive (ERalpha+) & -negative (ERalpha-) human breast cancer cells…

Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitro. Anticancer Res 2000; 20:3459–65-Abstract: Epidemiologic evidence indicates that both black & green tea is a rich source of flavonoids & other polyphenolic antioxidants which protects against heart disease and cancer. In the current investigation, utilizing human oral squamous carcinoma cell line SCC-25, we have evaluated the effect of three major tea constituents, (-)-epigallocatechin-3-gallate (EGCG), (-)-epicatechin-3-gallate (ECG) & (-)-epigallocatechin (EGC) on cell growth and DNA synthesis. Test agents in co…

Photochemoprotective Activity of Alcoholic Extract of Camellia sinensis, Int Jl of Pharmacog, 7(3) : 400-4, 2011.-Abstract: The main antioxidant polyphenols present in Camellia sinensis (green tea) are known as epicatechins which function as anti-inflammatory or anticarcinogenic agents. There are various évidences in the literature for the protective effects that green tea polyphenols exert on the skin’s immune system on oral & topical application. The aim of this study was to produce green tea extract & to evaluate its Photochemoprotective ability. The alcoholic extract of green tea leaves…

Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors, Molecules, 2019-Abstract: Due to changes in the dietary structure of individuals, the incidence of digestive tract tumors has increased significantly in recent years, causing a serious threat to the life & health of patients. This has in turn led to an increase in cancer prevention research. Many studies have shown that epigallocatechin-3-gallate (EGCG), an active ingredient in green tea, is in direct contact with the digestive tract upon ingestion, which allows it to elicit a significant an…

Antioxidant Activity from the Combination of Ethanolic Extract of Tea Leaves (Camellia sinensis) & Soursop Leaves (Annona muricata) & Optimation of the Effervescent Granule Production, Mutiaka Medika, 19 :2, 2019.-Abstract : Soursop Leaves (Annona muricata) & Tea Leaves (Camellia sinensis) are plants that contain flavonoids which are considered to act as antioxidants & can become chemopreventive agents. This study aims to identify the potential of Soursop Leaves & Tea Leaves as chemopreventive agents. The first stage of this research was to determine the presence of flavonoids in both of et…

Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene. Int JL Cancer. 2006;119(1):33-40--Abstract : To more clearly understand the molecular mechanisms involved in synergistic enhancement of cancer preventive activity with the green tea polyphenol (-)-epigallocatechin gallate (EGCG), we examined the effects of cotreatment with EGCG plus celecoxib, a cyclooxygenase-2 selective inhibitor. We specifically looked for induction of apoptosis & expression of apoptosis related genes, with emphasis on growth arrest & DNA dam…

Green tea polyphenols block endotoxin-induced tumor necrosis factor-production & lethality in a murine model. Jl Nutr. 1998;128(12):2334-40-Abstract :Green tea polyphenols are potent antioxidants. They have both anti-cancer & anti-inflammatory effects. However, their mechanisms of actions remain unclear. In inflammation, tumor necrosis factor-alpha(TNFalpha) plays a pivotal role. NF-KB, an oxidative stress -sensitive nuclear transcription factor, controls the expression of many genes including the TNFalpha gene. We postulated that green tea polyphenols regulate TNFalpha gene expression by m…

Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma & herpes simplex: Review Article, J der Deutschen Dermatologischen Gesellschaft, 8(10):788-96, 2010-Abstract:Plant extracts & isolated compounds are increasingly used in cosmetics & food supplements to improve skin conditions. We first introduce the positive plant monographs with dermatological relevance of the former German Commission E. Subsequently clinical studies with botanicals for atopic dermatitis, psoriasis, acne, condylomata acuminata & herpes simplex are discussed. The best studies have bee…

Mechanism of Action & Interactions between Thyroid Peroxidase & Lipoxygenase Inhibitors Derived from Plant Sources, Biomolecules, 9(11), 663, 2019-Abstract: This study focused on the effect of kaempferol, catechin, apigenin, sinapinic acid, & extracts from plants (i.e., parsley, cumin, mustard, green tea, & green coffee) on thyroid peroxidase (TPO) & lipoxygenase (LOX) activity, antiradical potential, as well as the result of interactions among them. Catechin, sinapinic acid, & kaempferol acted as a competitive TPO inhibitors, while apigenin demonstrated an uncompetitive mode of inhibitory …

Anti-inflammatory properties of oolong tea (Camellia sinensis) ethanol extract & epigallocatechin gallate in LPS-induced RAW 264.7 cells, Asian Pacific Jl of Trop Biomed, 1005-9, 2017-Abstract: To evaluate the anti-inflammatory activity of oolong tea ethanol extract (OTEE) & epigallocatechin gallate (EGCG) on lipopolysaccharide-induced murine macrophage cell line (RAW 264.7). Methods: A cytotoxic assay using MTS tetrazolium was conducted to find a nontoxic level of OTEE & EGCG toward RAW 264.7 cells. Interleukins (IL-6, IL-1β), tumor necrosis factor-α (TNF-α), & cyclooxigenase-2 (COX-2) lev…

Epigallocatechin Gallate Slows Retinal Degeneration, Reduces Oxidative Damage, & Modifies Circadian Rhythms in P23H Rats, Antioxidants (Basel), 9(8):718, 2020-Abstract: Retinitis pigmentosa (RP) includes a group of genetic disorders that involve the loss of visual function due to mutations mainly in photoreceptors but also in other retinal cells. Apoptosis, retinal disorganization, & inflammation are common in the progression of the disease. Epigallocatechin gallate (EGCG) has been proved as beneficial in different eye diseases. Pigmented heterozygous P23H rat was used as an animal model of…

Quantitation of the Total Catechin Content in Oils Extracted from Seeds of Selected Tea (Camellia sinensis (L) O. Kuntze, Theaceae) Clones by RP-HPLC, Am Jl of Plant Sciences, 6(7):1080-9, 2015-Abstract: Catechins (flavan-3-ols) are polyphenolic plant secondary metabolites that have been strongly associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. This study reports findings on the content of catechins in tea seed oil (TSO) extracted by Soxhlet extraction from seeds of different clones of Kenyan tea. Extraction of catechins from the crude oils was a…

Protective Role of Black Tea against Oxidative Damage of Human Red Blood Cells. Biochem & Biophysical Res Communications. 244, 903-7. 1998.

Protective Effects of Tea Polyphenols against Oxidative Damage to Red Blood Cells. Biochem Pharmacol. 54, 973-8.1997.

Apoptosis induction by epigallocatechin gallate involves its binding to Fas. Biochem Biophys Res Commun. 2001, 285: 1102-Abstract:

Epigallocatechin-3-gallate in AL amyloidosis: a new therapeutic option? Blood 110:2216, 2007-

Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols. Jpn Jl Cancer Res 1997; 88: 639–43.

Formulation & evaluation of herbal anti-acne moisturizer. Pak J Pharm Sci. 2012, 25(4):867-70.-Abstract: The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Acne vulgaris is one of the most commonly seen diseases among the youth. The present study is focused on the use of herbs as moisturizer for acne treatment. The anti-acne moisturizer was formulated from herbal crude extracts and investigated the Physico-chemical parameters as well as antibacterial activity of the formulation. The study re…

The in Vitro Antibacterial Efficacy of Persian Green Tea Extract as an Intracanal Irrigant on Enterococcus faecalis Biofilm, Iranian Endodontic J. 11(4):304-8, 2016--Abstract: The aim of this study was to compare the antibacterial effect of Persian green tea extract (GTE) & 2.5% sodium hypochlorite (NaOCl) against Enterococcus faecalis (E. faecalis) as an intracanal irrigant. Methods & Materials Thirty freshly extracted teeth were instrumented & sectioned into mesial & distal segments. The specimens were put into wells containing 2 mL of E. faecalis-containing medium. After 3 weeks, the sp…

Orthogonal analytical methods for botanical standardization: Determination of green tea catechins by qNMR & LC–MS/MS. Jl Pharm. Biomed. Anal. 2013,93, 59–67-

Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells. Biol Pharm Bull 2002; 25:1238–40.

Safety studies on epigallocatechin gallate (EGCG) preparations, part 1: genotoxicity. Food Chem Toxicol. 2006;44: 626-35.

Epigallocatechin-3-Gallate as a Potential Therapeutic Drug for TTR-Related Amyloidosis: “In Vivo” Evidence from FAP Mice Models, Plos-One, 2012-Abstract: Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease caused by the extracellular deposition of mutant transthyretin (TTR), with special involvement of the peripheral nervous system (PNS). Currently, hepatic transplantation is considered the most efficient therapy to halt the progression of clinical symptoms in FAP since more than 95% of TTR is produced by the liver. However, less invasive & more reliable therapeutic app…

Inhibitory effect of six green tea catechins & caffeine on the growth of four selected human tumor cell lines. Anticancer Drugs 1996; 7:461–8.

Epigallocatechin-3-gallate (EGCG): chemical & biomedical perspectives. Phytochemistry, 2006; 67:1849–55.

Effect of variable pressure-assisted immersion process using (−)-epicatechin on the color, flavor, & polycyclic aromatic hydrocarbons content in roasted beef meat, LWT, 178:114602, 2023-Abstract: Polycyclic aromatic hydrocarbons (PAHs) are more easily formed in beef meat than other meats. A previous study confirmed the inhibitory effect of (−)-epicatechin on PAHs in a fat model system. However, (−)-epicatechin solution demonstrates colloidal properties at high concentrations. Hence a variable pressure immersion method was applied to infuse (−)-epicatechin in beef cubes. The fixed variable p…

Polyphenols from green tea & pomegranate for prevention of prostate cancer, Free Radicals Res, 40(10) : 1025-104, 2009.-Abstract : Prostate cancer (PCa) is the most common non-cutaneous cancer diagnosed in North America with similar trends in many Western countries. Geographic, epidemiological & laboratory studies suggest a role for dietary constituents in the etiology as well as prevention of PCa. The rising incidence of PCa in several countries appears to be coincidental with adoption of western lifestyle. Increase in the incidence of PCa has also been found in Asian populations migrating…

Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer & normal cells from the human oral cavity. Toxicol in Vitro, 2005; 19:231–42.

Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo & serine proteases, Biol Chem, 383(1) :101-5, 2002-Abstract: Several reports have attributed to green tea chemopreventive & therapeutic properties. Epidemiological studies have linked the regular use of CS to a reduced incidence of breast & colon carcinomas. Tea contains several antioxidants, including polyphenols of the catechin (green tea) & theaflavin (black tea) groups. CS derivatives have been shown to act in vitro & in vivo as anti-inflammatory, anti-viral & anti-tumor drugs…

Green tea catechins & their oxidative protection in the rat eye, Jl of Agric a Food Chem, 58 (3) :1523–34, 2010.

Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status & expression of inflammatory & apoptotic genes in the rat ocular tissues, The Jl of Nutritional Biochem, 26 (11) :1357–67, 2015.

Green Tea Extract (Theaceae; Camellia sinensis L.): A Promising Antimicrobial, Anti-Quorum Sensing & Antibiofilm Candidate Against Multidrug-Resistant Campylobacter Species, Antibotics (Basel), 14(1):61. 2025-Abstract: Thermophilic Campylobacter species are among the main culprits behind bacterial gastroenteritis globally and have grown progressively resistant to clinically important antimicrobials. Many studies have been carried out to explore innovative and alternative strategies to control antibiotic-resistant campylobacters in animal reservoirs & human hosts; however, limited studies ha…

Profiling of phenolic composition in camellia oil & its correlative antioxidant properties analysis, Front Nutr, 23:11:1440279, 2024 -Abstract: Less research has been conducted on the association between camellia oil's (CO) phenolic composition & antioxidant capability. In this study, the phenolic profile of CO & its connection to antioxidant capacity were examined utilizing a combination of widely-targeted phenolic metabolomics & multivariate statistical analysis. A total of 751 phenolics were discovered. The WGCNA was used to link phenols to antioxidants, yielding 161 antioxidant-related …

Photoprotective effects of green tea polyphenols. Photodermatol Photoimmunol Photomed 2007; 23:48–56.

Green tea polyphenol epigallocatechin-3-gallate suppresses Toll-like receptor 4 expression via up-regulation of E3 ubiquitin-protein ligase RNF216, J of Biol Chem, 292 (10) :4077–8, 2017.

Assessment of aquo-ethanolic extract of Camellia sinensis against Carbapenem Resistant Escherichia coli: In Vivo Trials in a Murine Model, Biomed & Pharmacother, 79 : 273-83, 2013-Abstract : The prevalence of Carbapenem Resistant Escherichia coli (CRE) has increased considerably during the last décade, which can be ascribed to relative scarcity of effective non toxic antimicrobial agents. The present study was conducted to evaluate the antimicrobial activity of aquo-ethanolic (1:1) extract of leaves of Camellia sinensis against Carbapenem Resistant E coli at preclinical level using peritoni…

Anti-fibrotic effect of black tea (Camellia sinensis) extract in experimental pulmonary fibrosis. Tissue Cell 2019, 56, 14–22.Abstract: There is no effective therapy exists for Idiopathic pulmonary fibrosis (IPF) till now. Few studies have been done on protective effects of green tea in pulmonary fibrosis but there is no single report on CS extract (BTE) in pulmonary fibrosis so far. This study aims to investigate the anti-fibrotic effect of BTE against experimental pulmonary fibrosis. Four groups of animals were selected for this study. Group 1: control group mice. Group 2: mice exposed to…

Green tea constituent (-)-epigallocatechin-3-gallate inhibits Hep G2 cell proliferation and induces apoptosis through p53-dependent & Fas-mediated pathways. J Biomed Sci. 2003;10: 219-27.

Anticoccidial effect of green tea-based diets against Eimeria maxima. Vet Parasitol. 2007; 144(1-2):172-5.-Abstract: Anticoccidial effects of green tea (GT)-based diets were evaluated in chickens following oral infection with Eimeria maxima, an ubiquitous intestinal parasite of poultry that impairs the growth & feed efficiency of infected birds. Five-week-old chickens were assigned to four groups (GT 0.5%, GT 2.0%, untreated/infected and non-infected control) & each group consisted of 15 chickens. Chickens were fed a standard diet supplemented with ground green tea for 2 weeks prior to infe…

Antiviral activity of green tea & black tea polyphenols in prophylaxis & treatment of COVID-19: A review, Phytomed, 2021-Abstract: US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties. Method: We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea & theaflavins from black tea. Both green tea & black t…

Preparation & antioxidant activity of green tea extract enriched in epigallocatechin (EGC) & epigallocatechin gallate (EGCG), jl of Agric Food Chem, 57(4):319-53, 2009-Abstract:The present study investigated effects of solvents, temperature, & duration on extracting efficiency of catechins from green tea by an orthogonal test. The results suggested that extraction of epigallocatechin gallate (EGCG) was highly dependent on these factors, whereas that of epigallocatechin (EGC) was significantly affected by duration & solvent (P < 0.05). Effects of these factors on epicatechin (EC), catechin (…

Study on the antioxidant activity of tea flowers (Camellia sinensis). Asian Pac Jl Clin Nutr. 2007; 16 Suppl 1:148-52-Abstract: Major chemical compounds in different extracts from tea flowers (Camellia sinensis) were analyzed. Distilled water or 70% ethanol extracts were then fractionated with chloroform, ethyl acetate & n-butanol, respectively. Each extract fraction was tested its scavenging activities on 2, 2-diphenyl-1-picrylhydrazyl (DPPH) & hydroxyl free radicals. The results showed that ethyl acetate fraction of ethanol-extract of tea flower (EEA) exhibited the highest quenching activ…

EFFECT OF ALCOHOL EXTRACT OF GREEN TEA PLANT CAMELLIA SINENSIS AS A THERAPEUTIC TREATMENT OF PARASITE ENTAMOEBA HISTOLYTICA, Plant Archives 18(1), 2018-Abstract :This study aimed to investigate the effect of various concentrations of the extract of the green tea plant Camellia sinensis on the parasite causing the bloody diarrhea Entamoeba histolytica in laboratory mice where the extract of alcohol for green tea concentrations (100,150) mg/kg of the weight of the mouse has been used for 10 consecutive days It was found that the effect of the 100 mg / kg green extract of green tea reduced to …

Potential Utilization of Green Tea Leaves & Fenugreek Seeds Extracts as Natural Preservatives for Pacific White Shrimp During Refrigerated Storage, Foodborne Pathogens & Disease. 15(8): 2018.-Abstract: Ethanolic extracts of green tea leaves (GTE) & fenugreek seeds (FSE) were screened for their antibacterial activity against four food pathogenic strains using disc diffusion method. The two extracts revealed antimicrobial activity against selected bacterial strains. GTE showed the highest antibacterial activity to Escherichia coli & Staphylococcus aureus at a concentration of 1% with inhibiti…

Green tea catechins alleviate autoimmune symptoms & visual impairment in a murine model for human chronic intraocular inflammation by inhibiting Th17-associated pro-inflammatory gene expression. Sci Rep. 2019; 9 (1):2301-Abstract: Autoimmune uveitis is a sight-threatening disease mainly caused by dysregulation of immunity. We investigated the therapeutic effects of green tea extract (GTE) & its major component, epigallocatechin-3-gallate (EGCG), on a murine model of experimental autoimmune uveoretinitis (EAU). Oral administration of GTE, EGCG, dexamethasone, or water, which started 5 days b…

Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1. Int Jl Oncol 2002; 20:1233–9.

Anti-proliferative & proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. Int Jl Cancer 2005; 114:513–21.

Protective effect of green tea against ovarian & endometrial apoptosis in rats treated with depot medroxyprogesterone acetate, Biomarkers & Genomic Medicine, 7 (3): 105-9, 2015,-Abstract :This study aimed to investigate whether an extract of green tea (GT) modulates the apoptotic, superoxide-dismutase (SOD), & endothelial-nitric-oxide-synthase (eNOS) levels in rats treated with depot medroxyprogesterone acetate (DMPA). Twenty-five female Wistar rats were divided into the following groups (n = 5 rats each): control group, received DMPA, DMPA plus GT extract at doses of 10.8 mg/day (DMPA + GT…

New Dihydropyrrole-Substituted Epicatechins from Sun-Dried Dongting-Biluochun Tea Leaves & Their Inhibitory Activities on Acetylcholinesterase, ACS Publications, 1(3) :310-5, 2021-Abstract: Although Dongting-Biluochun tea is one of the top 10 teas in China, little research has been done on its chemical composition. The phytochemical study of leaves of Dongting-Biluochun tea resulted in the isolation of two new dihydropyrrole-substituted epicatechins, (−)-6-(5″R)-2″-ethoxy-3″,4″-dihydro-2H-pyrrole-epicatechin-3-gallate (1) & (−)-6-(5″R)-2″-ethoxy-3″,4″-dihydro-2H-pyrrole-epicatechin (2), alo…

Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006; 66:1234–40-Abstract: Green tea catechins (GTCs) proved to be effective in inhibiting cancer growth in several experimental models. Recent studies showed that 30% of men with high-grade prostate intraepithelial neoplasia (HG-PIN) would develop prostate cancer (CaP) within 1 year after repeated biopsy. This prompted us to do a proof-of-principle clinical trial to …

Neuroprotective & neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease, Neurobiol of Disease,22(2):421-31, 2003-ABSTRACT :In the present study, an attempt has been made to explore the neuroprotective & neuroreparative (neurorescue) effect of black tea extract (BTE) in 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (PD). In the neuroprotective (BTE + 6-OHDA) & neurorescue (6-OHDA + BTE) experiments, the rats were given 1.5% BTE orally prior to & after intrastriatal 6-OHDA lesion respectively. A significant recovery in d…

Anthelmintic activity of Tea (Camellia sinensis) extract, Inter Jl of Pharma Sci & Res.1(11), 2010, 451-3-ABSTRACT : The aim of present study was the evaluation of anthelmintic activity of Tea Powder (Camellia sinensis) extract in experimental adult earthworm’s Pheretima posthuma. The alcoholic & aqueous extract of Tea Powder (Camellia sinensis) show potent anthelmintic activity. Tea is the most popular drunk beverage in world. Tea contain more than 700 chemicals like caffeine polysaccharides, théobromine, gallotannic acid, vitamins (C, E & K), amino acids, which are closely related to hu…

Cancer prevention with green tea polyphenols for the general population, & for patients following cancer treatment. Current Cancer Therapy Reviews. 1, 109-14.205.

Green tea (Camellia sinensis) & its antioxidant property: A review. Int Jl Pharm Sci Res 2018;9:1723-36.

green tea halts progression of cardiac transthyretin amyloidosis: an observational report, Clin Res in Cardiology, 101:805-13, 2012-Abstract: Treatment options in patients with amyloidotic transthyretin (ATTR) cardiomyopathy are limited. Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea (GT), inhibits fibril formation from several amyloidogenic proteins in vitro. Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomyopathy. Methods: 19 patients with ATTR ca…

Influence of the addition & storage time of crude extract of tea leaves (camellia sinensis l.) toward value of free fatty acid in crude palm oil, IOP Conference Series: Earth & Environ Science,4:conf 1, 2012-Abstract : The purpose of this study was to determine the effect of the crude extract of tea leaves (Camellia sinensis L.) & storage time on the content of free fatty acid in palm oil. The dried tea leaves were macerated and concentrated by rotary evaporator. The extract obtained was added to crude palm oil with various added mass of the extract &various storage times. Phytochemical tes…

Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis), Acta Cirurgica Bras, 27(9):634-8, 2012.-Abstract: To evaluate the antitumor activity of alcoholic extracts of green tea (Camellia sinensis). Four groups of six Wistar rats were inoculated intramuscularly with 10(6) Walker tumor cells/mL. During 10 days, the animals received by gavage either 0.9% saline solution (Group I; negative control), solution containing 20 mg/Kg of tamoxifen (Group II; positive control), solution containing 0.07 g/Kg alcoholic extract of C. sinensis (Group II…

Anti-inflammatory & antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition, Sci Rep, 15(1):2371. 2025--Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by immune dysregulation & excessive cytokine production. This study aimed to explore the potential of Camellia sinensis L. water extract (CSE) as a treatment for AD by the impact of CSE on inflammatory responses in keratinocytes, particularly concerning the production of inflammatory cytokines & the modulation of signaling p…

Green tea polyphenols & cancer chemoprevention: multiple mechanisms and endpoints for phase II trials. Nutr Rev 2004; 62:204–11.

Inhibitory effects of polyphenol-enriched extract from Ziyang tea against human breast cancer MCF-7 cells through reactive oxygen species-dependent mitochondria molecular mechanism, Jl of Food & Drug Analysis, (2016)-Abstract: A polyphenol-enriched extract (ZTP) from sélénium-enriched Ziyang green tea was selected to evaluate its antitumor effects against human breast cancer MCF-7 cells. In ZTP, (−)-epigallocatechin gallate (28.2%) was identified as the major catechin, followed by (−)-epigallocatechin (5.7%) and (−)-epicatechin gallate (12.6%). ZTP was shown to inhibit MCF-7 cell proliferat…

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis, Clin Res Cardiol 99, 483–90 (2010)-Abstract: Amyloid light chain (AL) amyloidosis is a rare disease with poor prognosis & limited therapeutic alternatives. Recently, one clinical case with cardiac involvement, as well as a compelling evidence of green tea polyphenol, epigallocatechin-3-gallate (EGCG), inducing the formation of benign aggregation products that do not polymerize into fibrils were published. This is a report of the cardiac effects of green tea consumption…

Phenolic content & in vitro inhibitory effects on oxidation & protein glycation of some Thai medicinal plants, Pak jl of Pharm Sci, 23(4):403-8-Abstract: Fifteen medicinal plant extracts were investigated for: total phenolic content & free radical scavenging effect by DPPH & ABTS assays; anti-lipid peroxidation activity by TBARS; & for antiglycation activity. The results revealed that the total phenolic content showed good correlation with free radical scavenging by ABTS (r = 0.721) & anti-lipid peroxidation by TBARS (r = -0.659), but showed no correlation with antiglycation. Three extracts…

HR-MASNMR chemical profile & chemometric analysis as a tool for quality control of different cultivars of green tea (Camellia sinensis). Food Chem. 2023,408, 135016.

EGCG impedes human Tau aggregation & interacts with Tau, Scientific Reports, 2020-Abstract:Tau aggregation & accumulation is a key event in the pathogenesis of Alzheimer’s disease. Inhibition of Tau aggregation is therefore a potential therapeutic strategy to ameliorate the disease. Phytochemicals are being highlighted as potential aggregation inhibitors. Epigallocatechin-3-gallate (EGCG) is an active phytochemical of green tea that has shown its potency against various diseases including aggregation inhibition of repeat Tau. The potency of EGCG in altering the PHF assembly of full-length h…

Extraction of Epigallocatechin Gallate & Epicatechin Gallate from Tea Leaves Using β-Cyclodextrin, J of Food Sci, 82(2):394-400, 2017-Abstract: Use of organic solvents to extract phenolic compounds from plants may result in environmental pollution & cause health problems in persons. Replacing organic extraction solvents by green extracting agents without affecting the extraction yield is one of the most pressing problems to be solved. The aim of this study is to evaluate the capacity of β-cyclodextrin (β-CD) to recover phenolic compounds from tea leaves. The extract obtained using the ethan…

Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the Retina caused by ischemia/reperfusion, Brain Res, 1159 : 40–53, 2007-Abstract: The aim of this study was to examine whether the antioxidant epigallocatechin gallate (EGCG), a catechin-base flavonoid derived from green tea protects retina neurones in situ from ischemia/reperfusion & in vitro from an oxidative stress insult of hydrogen peroxide (H(2)O(2)). Similar results were obtained when rats were injected by two different regimes of EGCG. Ischemia was delivered by raising the intraocular p…

Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. BMBRep 2015; 48:461e6.

In-silico drug repurposing for targeting SARS-CoV-2 main protease (M pro), Jl Biomol Struct Dyn, 2020-Abstract: COVID-19, caused by novel coronavirus or SARS-CoV-2, is a viral disease which has infected millions worldwide. Considering the urgent need of the drug for fighting against this infectious disease, we have performed in-silico drug repurposing followed by molecular dynamics (MD) simulation & MM-GBSA calculation. The main protease (Mpro) is one of the best-characterized drug targets among coronaviruses, therefore, this was screened for already known FDA approved drugs & some natural …

Green tea catechins are potent antioxidants that ameliorate sodium iodate-induced retinal degeneration in rats, Scientific Reports, 6 (1) : art 29546, 2016.-Abstract: Green tea extracts exhibit anti-oxidative & anti-inflammatory actions in different disease conditions. We hypothesized that green tea extract & its catechin constituents ameliorate sodium iodate-induced retinal degeneration in rats by counteracting oxidative stress. In this study, adult Sprague-Dawley rats were intravenously injected with a single dose of sodium iodate. Green tea extract (GTE; Theaphenon-E) or combinations of …

EVALUATION OF IN VITRO & IN VIVO ACTIVITIES OF SOME MEDICINAL PLANTS EXTRACTS AGAINST TRYPANOSOMIASIS. Inter Jl of Advanced Res, 1169 – 78. 2016.-Abstract: This study aimed to assess the Antitrypanosomal activity of leaf ethanolic extracts against Trypanosoma evansi experimental infection. Seven medicinal plants: Camellia sinensis, Thymus vulgaris, Mentha longifolia, Azadirachta indica, Olea europaea, Rosmarinus officinalis & Saliva officinalis, were selected based on information from traditional healers on their curative effect against parasites. They were investigated for phytochemical sc…

Potential roles of circulating microRNAs in the healing of type 1 diabetic wounds treated with green tea extract: molecular & biochemical study, Heliyon, 9(1):e22020, 2023--Abstract: Circulating miRNAs have been implicated in various aspects of diabetic wound healing, including inflammation, angiogenesis, & extracellular matrix remodeling. Thus, in alternative herbal medicine strategies, miRNAs will be potential therapeutic molecular targets in nonhealing wounds. These could be valuable elements for understanding the molecular basis of diabetic wound healing & could be used as good elements…

green tea polyphenols & its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro & in vivo, Cancer Letters, 245(1-2) :232-41, 2007-Abstract: Epidemiologic evidence indicates that both black & green tea is a rich source of flavonoids and other polyphenolic antioxidants which protects against heart disease & cancer. In the current investigation, utilizing human oral squamous carcinoma cell line SCC-25, we have evaluated the effect of three major tea constituents, (-)-epigallocatechin-3-gallate (EGCG), (-)-epicatechin-3-gallate (EC (-)-epigallocate…

Extraction of antioxidants & caffeine from green tea (Camelia sinensis) leaves: kinetics & modeling, Food Chem Int, 16(6):505-10, 2010-abstract:The effects of temperature (50, 60, 70, 80, 90 °C) & time (5, 10, 20, 40, 80 min) on catechins & caffeine solubility in water from Iranian green tea were investigated, The best combinations of temperature & time extraction with water were 20-40 min, 80 °C for epigallocatechin (EGC), epicatechin (EC) & caffeine (Caff), & 80 min, 90 °C for catechin (C), epicatechin gallate (ECG) & epigallocatechin gallate (EGCG). A mathematical model derived from Fick…

Inhibitory effect of epigallocatechin from Camellia sinensis leaves against proinflammatory mediator release in macrophages, Jl Appl Biol Chem; 60(3): 199-205. 2017-Abstract : To investigate the anti-inflammatory activity of natural products, we determined the anti-inflammatory activity of purified epigallocatechin (EGC) from Camellia sinensis leaves. In the present study, we found that EGC inhibited the production of proinflammatory mediators (IL-6, TNF-α, NO & PGE2) in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells. Suppression of IL-6 seems to be at least partly attributable to the …

Metabolomics of green-tea catechins on vascular-endothelial-growth-factor-stimulated human-endothelial-cell survival, Jl of Agric & Food Chem, 66 (48) :12866–75, 2018.

Phenolic content & antioxidative capacity of green & white tea extracts depending on extraction conditions & the solvent used, Food chem, 110:4, 852-8, 2008-Abstract:The efficiencies of different solvents in the extraction of phenolics from bagged & loose leaves of white & green tea, after different extraction times, as well as the antioxidative capacity of the obtained extracts, were investigated. The developed HPLC method has the potential to separate & determinate 17 phenolics widely distributed in plants, but in investigated tea extracts only four catechins & traces of three flavonols &…

Effects of black tea consumption on plasma catechins & markers of oxidative stress & inflammation in patients with coronary artery disease, Free Rad Biol Med, 38(4):499-506, 2004-Abstract:We previously demonstrated that black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. To investigate potential mechanisms of this effect, we examined plasma catechins & systemic markers of oxidation, inflammation, & antioxidant protection from 66 subjects enrolled in that study. We collected samples at baseline, 2 h after 450 ml of black tea (acute), after 4 weeks…

Antimicrobial & Antitumor Activities of Seed Extracts of Camellia sinensis L. Korean Society of Food Sci & Technol, 37(1) : 108-12, 2005-Abstract : Antimicrobial & antitumor activities of Camellia sinensis L seed extracts were investigated. Seed extracts showed antifungal activities against Candida albicans IFO 1594 & Cryptococcus neoformans. Inhibition zone of 20 mm was shown by 70% ethanol extract against C. albicans IFO 1594 at 100 mg/mL. Antifungal activity of seed extract was not decreased by heating at 80 & 100∘C100∘C for 30 min or at 121∘C121∘C or 15 min, indicating heat-stability of…

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: An observational study. Drug Des. Devel. Ther. 2015;9:6319–25. doi: 10.2147/DDDT.S96893-Abstract: Causative treatment of patients with wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM) is lacking. Recent reports indicate the potential use of epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, to inhibit amyloid fibril formation. We sought to investigate changes of cardiac function & morphology in patients with wtATTR-CM after consumption of green tea extract (GTE). Method…

Synergisms in Alpha-glucosidase Inhibition & Antioxidant Activity of Camellia sinensis L. Kuntze & Eugenia uniflora L. Ethanolic Extracts, Pharmacognosy Res, 9(1):101-7.2017-Abstract: Camellia sinensis, the most consumed & popular beverages worldwide, and Eugenia uniflora, a Brazilian native species, have been already confirmed to have beneficial effects in the treatment of diabetes mellitus. However, their potential acting together against an enzyme linked to this pathology has never been exploited. Objective: The aim of this study was to evaluate the inhibitory properties of individual & …

In vitro antibacterial activity of Camellia sinensis extract against cariogenic microorganisms. Jl Basic Clin Pharma 2015; 6:35-9-Abstract: The aim was to evaluate the in vitro antimicrobial activity of Camellia sinensis extract on S. mutans & L. acidophilus. Materials & Methods: Aqueous, acetone & ethanolic extracts of C. sinensis were subjected to antioxidant analysis. The ethanolic extract was used for assessment of antimicrobial properties. Ethanolic green tea extract at ten different concentrations & 0.2% chlorhexidine was used. Microbiological investigations were carried out to determ…

Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines. Jpn Jl Cancer Res, 1999; 90:733–9.-Abstract :It is now well accepted that (-)-epigallocatechin gallate (EGCG) inhibits carcinogenesis in the digestive tract in rodents. To understand the mechanisms of anticarcinogenesis, we first studied growth inhibition by EGCG in human stomach cancer cell lines established at Seoul National University (SNU cell lines). Inhibition by EGCG of [3H]thymidine incorporation into eight SNU cell lines was examined, in relation to transforming growth …

Green tea & its polyphenolic catechins: medicinal uses in cancer & non-cancer applications. Life Sci 2006; 78:2073–80-Abstract: Can drinking several cups of green tea a day keep the doctor away? This certainly seems so, given the popularity of this practice in East Asian culture & the increased interest in green tea in the Western world. Several epidemiological studies have shown beneficial effects of green tea in cancer, cardiovascular, & neurological diseases. The health benefits associated with green tea consumption have also been corroborated in animal studies of cancer chemoprevention,…

Antitumor activity of cell suspension culture of green tea seed (Camellia sinensis L.), Biotechnol & Bioprocess Engineering, 11: 39, 2006-Abstract: The objective of this study was to investigate the antitumor activity of suspension cultures of tea callus cells grown in the presence of different concentrations of the growth regulator 2,4-dichlorophenoxy acetic acid (2,4-D) with or without light irradiation. The methanol & ethanol extracts of precipitated cells (MEP, EEP) exhibited stronger inhibitory effects on the growth of tumor cell lines than the water extract of precipitated cells (WEP)…

Cymbopogon citratus & Camellia sinensis extracts selectively induce apoptosis in cancer cells & reduce growth of lymphoma xenografts in vivo. Oncotarget. 8(67):110756-73. 2017.-Abstract: Cymbopogon citratus (lemongrass) & Camellia sinensis (white tea) extracts have been shown to have medicinal properties, however, their activity against lymphoma & leukemia, as well as mechanistic details, have not been fully characterized. Herein, we report potent anti-cancer properties in dose & time-dependent manners of ethanolic lemongrass & hot water white tea extracts in lymphoma & leukemia models. Bot…

Medicinal plants & natural products in amelioration of arsenic toxicity: a short review. Pharm Biol. 2017;55(1):349–54-Abstract:  Chronic arsenic toxicity (arsenicosis) is considered a serious public health menace worldwide, as there is no specific, safe, & efficacious therapeutic management of arsenicosis. Objectives: To collate the studies on medicinal plants & natural products with arsenic toxicity ameliorative effect, active pre-clinically and/or clinically. Methods: Literature survey was carried out by using Google, Scholar Google & Pub-Med. Only the scientific journal articles found o…

Evaluation of Anticancer Activity of Camellia Sinensis in the Caco-2 Colorectal Cancer Cell Line, Asian Pac Jl Cancer Prev. 19(6):1697-701. 2018-Abstract: Camellia sinensis, whose leaves are used to produce green tea was evaluated for anticancer effects in cell culture. MATERIALS & METHODS: A hydroalcoholic extract of C sinensis young leaves was prepared by percolation & compared with Cisplatin as a known anticancer drug for effects on two cell lines: Caco-2, colon carcinoma cells, & mouse normal fibroblasts (L929). Cytotoxicity of 50, 100, 200, 400 & 800 μg/ml of C sinensis extract was ev…

Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential & other therapeutic application, Arabian Jl of Chem, 16(5) :104680, 2023-Abstract: The aim of this updated & comprehensive review is to bring together the latest data on the phytochemistry & pharmacological properties of Camellia sinensis & to highlight the therapeutic prospects of the bioactive compounds in this plant so that the full medicinal potential of CS can be realised. A review of published studies on this topic was performed by searching PubMed/MedLine, Scopus, Google scho…

Effects & molecular mechanisms of selenium-containing tea polysaccharides on human breast cancer MCF-7 cells. Jl Agric Food Chem 2013; 61:579e88.-Abstract : Dietary supplementation of selenium-enriched tea is known to have an anticancer health benefit. This study was to investigate the inhibitory effect of selenium-containing tea polysaccharides (Se-GTPs) from a new variety of selenium-enriched Ziyang green tea against human MCF-7 breast cancer cells. Se-GTPs dose-dependently exhibited an effective cell growth inhibition with an IC(50) of 140.1 μg/mL by inducing MCF-7 cancer cells to underg…

Differential Growth Suppression of Human Melanoma Cells by Tea (Camellia sinensis) Epicatechins (ECG, EGC & EGCG), Evidence-based Comp &Alter Med, 6(4):523-30, 2008.-Abstract: We previously reported that catechins of green tea have different antiproliferative effects on cell lines derived from gender-dependent cancers; epicatechin 3-gallate (ECG) had the strongest inhibitory effect. In the present study, we examined the effects of epigallocatechin (EGC), epicatechin-gallate (ECG) & EGC 3-gallate (EGCG) on the viability, density, doubling time & cycle number of cell lines derived from melano…

Prostate cancer chemoprevention by green tea: In vitro & in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase, Cancer Research, 59(9):2115-20,1999-Abstract : Green tea polyphenols (GTPs) possess strong chemopreventive properties against a variety of animal tumor models & in some human epidemiological studies. At least two epidemiological studies have suggested that people who consume tea regularly may have a decreased risk of PCA. In this study, we investigated the effect of GTPs against testosterone-mediated induction of ODC in human prostate carcinoma cells, LN…

The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovarian Syndrome in Rat. Iran Jl Pharm Res. 2015. Fall; 14(4):1215-33.-Abstract: Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which the level of oxidative elements in blood rises. Green tea is a potent antioxidant since it contains catechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined. For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, the rats were divided into four groups incl…

Effects of Camellia sinensis Ethanolic Extract on Histometric & Histopathological Healing Process of Burn Wound in Rat, Middle-Est Jl of Sci Res, 13(1): 148, 2013.-Abstract: GT- Camellia sinensis that were used as an ancient herbal drug in Asia, with having anti-oxidant & anti-inflammatory properties, may can improve wound healing process, therefore the present study were design to determinate the effect of green tea ethanolic extract on burn wound healing process in rat. For this experimental study, 36 healthy male Wistar rats were randomly selected into three groups of A, B & C which, res…

Bioavailability & antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals. Jl Nutr Biochem 16:610–6, 2005-Abstract:Tea polyphenols have strong in vitro antioxidant activity. Due to their limited bioavailability, however, their contribution to in vivo antioxidant activity may depend on the form of administration. A human intervention study was performed to evaluate the bioavailability & antioxidant capacity of (−)-epigallocatechin-3-gallate (EGCG) administered as a single large dose in the form of either purified EGCG or…

Study of Cytotoxic Activity of Olive & Green Tea Extracts on Breast Tumor Cell Line, Jl Ardabil Univ Med Sci 2010, 10(4): 287-94-Abstract: There are many problems in treatment of different kinds of tumors. Many studies were carried out for finding suitable antitumor materials in different countries. The aim of this study is to evaluate the antitumor effects of olive & green tea extracts on human breast tumor cell line (BT474). Methods: Water & ethanol extracts of green tea & olive were prepared. BT474 cells were treated with determined concentration of extracts at different incubation times…

Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors Jl of Biomel Struc & Dynamics, 39:10, 2021 -Abstract: The main protease (Mpro) is a well characterized & attractive drug target because of its crucial role in processing of the polyproteins which are required for viral replication. In order to provide potential lead molecules against the Mpro for clinical use, we docked a set of 65 bioactive molecules of Tea plant followed by exploration of the vast conformational space of protein-ligand complexes by long term molecular dynamics (MD) simulations (1.5…

Green tea extract attenuates LPS-induced rétinal inflammation in rats, Scientific Reports, 8 (1):429, 2018.-Abstract: Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness & visual impairment. We have previously demonstrated that Green Tea Extract (GTE) is a potent anti-inflammatory agent for anterior uveitis. Here we investigated the anti-inflammatory effect of GTE on lipopolysaccharides (LPS)-induced retinal inflammation in rats & explored the underlying mechanism. Adult rats were injected with LPS and GTE was administered intra-gastrically at 2, 8, 26 & 3…

Green Tea (Camellia sinensis) Extract Induces p53-Mediated Cytotoxicity & Inhibits Migration of Breast Cancer Cells, Foods 10(12):3154, 2021-Abstract: Green tea (GT) has been shown to play an important role in cancer chemoprevention. However, the related molecular mechanisms need to be further explored, especially regarding the use of GT extract (GTE) from the food matrix. For this study, epigallocatechin gallate (EGCG) & epigallocatechin (EGC) were identified in GTE, representing 42 & 40% of the total polyphenols, respectively. MDA-MB-231 (p53-p.R280K mutant) & MCF-7 (wild-type p53) breast…

Activity of Antioxidant & Inhibitor α-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) & Tea Benalu (Scurulla atropurpureea BL Dans), Jl OF SCI INNOVARE, 01 :01, 2018-Abstract. Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants & anti diabetic. The α-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by disso…

in vitro Anthelmintic Activity of Ethanolic Extracts of Camellia sinensis L. & Albizia lebbeck L. against Haemonchus contortus, Panjab Univ Jl of Zoology, 34(1): 41-5, 2019-Abstract: The aim of this study was to evaluate the anthelmintic potential of two local plants, Albizia lebbeck L. & Camellia sinensis L against Haemonchus contortus using Adult Motility Assay (AMA). Crude Ethanolic Extracts (CEE) of dried leaves of A. lebbeck & whole plant of C sinensis were prepared by cold maceration method. The anthelmintic activity was analyzed by adult motility assay (AMA). Levamisole was used as p…

Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity & therapeutic implications, Am Soc of Hematol, 2006-Abstract:Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive & chemotherapeutic actions. Based on its ability to modulate growth factor-mediated cell proliferation, we evaluated its efficacy in multiple myeloma (MM). EGCG induced both dose- & time-dependent growth arrest & subsequent apoptotic cell death in MM cell lines including IL-6-dependent cells & primary…

Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies. Leuk Res 30:707–712, 2006-Abstract : Green tea or its constituents have long been touted as a health promoting substance including claims it may have cancer prevention properties. We previously reported the in vitro ability of one tea polyphenol, epigallocatechin gallate (EGCG), to induce apoptotic cell death in the leukemic B-cells from a majority of patients with chronic lymphocytic leukemia (CLL). After the publication of our findings many patients with CLL & other low grade lymphomas began u…

Appetite-Suppressing & Satiety-Increasing Bioactive Phytochemicals: A Systematic Review. JL M. Nutrients. 2019, 11(9):2238-Abstract: The prevalence of obesity is increasing worldwide. Bioactive phytochemicals in food supplements are a trending approach to facilitate dieting & to improve patients' adherence to reducing food & caloric intake. The aim of this systematic review was to assess efficacy & safety of the most commonly used bioactive phytochemicals with appetite/hunger-suppressing and/or satiety/fullness-increasing properties. To be eligible, studies needed to have included at least …

Mechanism-based inhibition of cancer metastasis with (−)-epigallocatechin gallate, Biochem & Biophysical Res Com, 454(1):1-6, 2014-Abstract: Cell motility & cell stiffness are closely related to metastatic activity of cancer cells. (−)-Epigallocatechin gallate (EGCG) has been shown to inhibit spontaneous metastasis of melanoma cell line into the lungs of mice, so we studied the effects of EGCG on cell motility, cell stiffness, and expression of vimentin and Slug, which are molecular phenotypes of epithelial–mesenchymal transition (EMT). Treatments of human non-small cell lung cancer cell li…

Prooxidant property of green tea polyphenols epicatechin & epigallocatechin-3-gallate: implications for anticancer properties, Toxicol in Vitro, 18(8) :555-61, 2004-Abstract: It is believed that anticancer & apoptosis inducing properties of green tea are mediated by its polyphenolic constituents particularly catechins. A number of reports have shown that green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) is among the most effective chemopreventive & apoptosis-inducing agents present in the beverage. Plant polyphenols are naturally occurring antioxidants but they also exhibit prooxid…

Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. Pre prints 2020, 2020030226 (doi: 10.20944/ preprints 202003.0226.v1)-Abstract : COVID-19 a new strain of coronavirus (CoV), was identified in Wuhan, China, in 2019. No specific therapies are available & investigations regarding COVID-19 treatment are lacking. Liu et al. (2020) successfully crystallized the COVID-19 main protease (Mpro), which is a potential drug target. The present study aimed to assess bioactive compounds found in medicinal plants as potential COVID-19 M…

Combined Inhibitory Effects of Green Tea Polyphenols & Selective Cyclooxygenase-2 Inhibitors on the Growth of Human Prostate Cancer Cells Both In vitro & In vivo, Clin Cancer Res, 13(5):1611-9, 2007-Abstract : Cyclooxygenase-2 (COX-2) inhibitors hold promise for cancer chemoprevention; however, recent toxicity concerns suggest that new strategies are needed. One approach to overcome this limitation is to use lower doses of COX-2 inhibitors in combination with other established agents with complementary mechanisms. In this study, the effect of (-)epigallocatechin-3-gallate (EGCG), a promisin…

Green Tea Constituent Epigallocatechin-3-Gallate & Induction of Apoptosis & Cell Cycle Arrest in Human Carcinoma Cells, Jl of the Nat Cancer Institute, 89(24):1881-6, 1998.-Abstract : The polyphenolic compounds present in green tea show cancer chemopreventive effects in many animal tumor models. Epidemiologic studies have also suggested that green tea consumption might be effective in the prevention of certain human cancers. We investigated the effect of green tea polyphenols & the major constituent, epigallocatechin-3-gallate, on the induction of apoptosis (programmed cell death) & regulat…

Effect of Ethanolic Extract of Green Tea (Camellia Sinensis) on Intra-Abdominal Adhesions in Rats, Jl of Zanjan Univ of Med Sci & Health Services, 21(86):86-96, 2013.-Abstract: Adhesion bands comprise the most important unpleasant consequences of pelvic surgeries. Camellia sinensis, due to its anti-oxidant & anti-inflammatory effects & prevention of production & accumulation of collagen seems to be beneficial in this event. Therefore, the present study was designed to elicit the effect of alcoholic extract of green tea on intra-abdominal adhesions. Materials & Methods: In this experimental …

Herbal composition for treatment of hyperlipidemia & the inhibition of myocardial infarction: Abstract: A pharmaceutical or medicinal herbal composition and method of making the composition comprised of a mixture of the following herbal ingredients: Glycine max, Plumbago zeylanica, Terminalia Arjuna, Trigonella-foenum-graecum, Coleus forskohlii, Commiphora mukul, Camellia sinensis & Azadirachta indica. . Composition detaillée: -Glycine max seed extract in an amount of 10-15% by weight of the composition, wherein the Glycine max seed extract contains about 40% isoflavones; -Plumbago zeylanic…