Acalypha wilkesiana (Jipon-kankan) : vertus médicinales en extraction alcoolique

Alade PI et al.  Anti-microbial activities of crude extracts of Acalypha wilkesiana, J.  Ethnopharmacol 1993; 39:  171-1.

Onuah CL et al, Ethanol Extract of Acalypha wilkesiana Muel Arg. Leaves Ameliorates Paracetamol-induced Hepatotoxicity in Rats, Intern J of Biochemistry Res & Review, 12 :2, -Objective: The effect of ethanol leaf extract of A. wilkesiana on the liver of paracetamol- induced hepatotoxicity was investigated in Wistar albino rats. Methods: Liver toxicity was induced with 2000 mg/kg body weight of paracetamol (PARA) orally. The extract was administered to paracetamol treated Wistar albino rats at a dose of 100 mg/kg, 200 mg/kg and 300 mg/kg body weight. Qualitative phytochemical analysis of the…

Ezekiel CN et al. antimicrobial activity of the methanolic & crude alkaloid extracts of Acalypha wilkesiana cv.  Macafeana Copper leaf, Res J of Microbiology 2009; 4(7): 269-77.

Ogbuehi I et al. Effect of Acalypha wilkesiana Muell Arg. leaf extract on the oxidative indices, liver enzymes & liver integrity of rats infected with Plasmodium berghei. British J of Pharmacology & Toxicology. 2014;5(2):68-74.

Abhinaya M et al ANTINOCICEPTIVE EFFECT OF ETHANOLIC FLOWER EXTRACT OF ACALYPHA WILKESIANA PLANT Ind Am J of Pharm Res Abstract: The flowers of Acalypha wilkesiana are commonly used for the treatment of pain, fever and ulcer by traditional medical practitioners without any scientific data to evaluate the appropriateness of some of the practices. Therefore, this present investigation was carried out to evaluate the ethanolic extract of flowers of A wilkesiana for analgesic & antiinflammatory activities using different models of pain & inflammation. The hot plate latency assay, Eddy’s hot pla…

Ogbo EM et al, Effects of three plants extract (Ocimum gratissimum, Acalypha wilkesiana & Acalypha Macrostachya) on post-Harvest pathogen of Persea Americana. J. Med Plants Res 2008; 2: 311-4.- Abstract: Disease assessment of Persea americana (Avocado) in a local market in Delta State Nigeria showed that only 7% of the fruits were healthy. 36% of the Avocado fruits had Cercospora spot; 28% had Diotherella rot & 29% had anthracnose. Plant extracts of three different species; Ocimum gratissimum, Acalypha wilkesiana & Acalypha Macrostachya were assessed for inhibitory effect on the radial grow…

Eugene NO et al. Quantitative high performance liquid chromatographic analysis of simple terpenes, carotenoids, phytosterols & flavonoids in the leaves of Acalypha wilkesiana Muell Arg. Pac J Sci Technol 2010;11:480-7.

HALIMAH E et al, CYTOTOXIC ACTIVITY FROM ETHANOL EXTRACT & FRACTIONS OF SABLO (ACALYPHA WILKESIANA) LEAVES, ON HeLa SERVICAL CANCER CELLS, , The 2th Int Seminar & Expo in JAMU, 2017.-Abstract : Cancer is still one of the main health problems in the world. Cervical cancer is a leading cause of cancer deaths in women worldwide. In parts of the developing world, cervical cancer is the major cause of death in women of reproductive age. Conventional therapies to treat cancer are still unsatisfied, so needed an alternative therapy that is by consuming preparations of natural ingredients. One of t…

Forcados GE et al, Acalypha wilkesiana: Therapeutic & Toxic Potential. J Med Surg Pathol 1:122, 2016.-Abstract :Acalypha wilkesiana is a plant that is attracting research interest due to its widely reported application in traditional health care systems. A wilkesiana is reportedly used in the treatment of a number of diseases including diarrhea, gastrointestinal disorders, fungal skin infections, hypertension and diabetes mellitus among others. Such claims are currently undergoing investigation by scientists in different Laboratories across the globe. Toxicologists are also examining safety…

AZUBUIKE CP et al, Evaluation of antimicrobial properties of herbal ointments formulated with ethanolic extract of Acalypha wilkesiana.  J Biol Sci Opin 2013; 1(2): 41-4-Abstract: The antimicrobial activity of ethanolic extract of dried fresh leaves of Acalypha wilkesiana & also those of the ointments formulated with the extract was evaluated. The preliminary in vitro antimicrobial activity of the extract at concentrations of 2.5 mg/ml, 5 mg/ml and 10 mg/ml and those of the ointments was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, As…

Kingsley O et al, Toxicological implications of the therapeutic use of Acalypha wilkesiana leaves in traditional medicine;, Clin Phyto-Science, 2017-Abstract: In traditional medicine, Acalypha wilkesiana is frequently used solely or as a composite part of many herbal preparations for therapeutic purposes. This study was therefore conducted to evaluate the effects of oral administration of extracts of Acalypha wilkesiana leaves, on some serum diagnostic enzymes in normal experimental rabbits. Methods: Eighteen adult male experimental rabbits were randomized into three groups (A, B & C), comp…

Omage K et al, Implications of oral administration of extracts of Acalypha wilkesiana leaves on serum electrolytes, urea & creatinine in normal experimental rabbits, Nigerian Society for Expérimt Biol, 2015-The leaves of Acalypha wilkesiana are eaten as vegetables as part of the traditional management of hypertension in Nigeria. This study was therefore conducted to evaluate the implications of oral administration of extracts of Acalypha wilkesiana leaves, on serum electrolytes, urea & creatinine, in normal experimental rabbits. A total of eighteen (18) rabbits were randomized into three gr…

Oladunmoye MK.  Comparative evaluation of anti-microbial activities & phytochemical screening of two varieties of Acalypha wilkesiana. Trends Applied Sci.  Res 2006; 1:  538-41.

Omage K et al, Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets, Clinical Phyto sciences, 4(1):2018.-Abstract: This study was conducted to evaluate the therapeutic benefits of oral administration of extracts of A wilkesiana leaves on some serum parameters that are Indicators or risk factors of cardiovascular diseases, in salt loaded rabbits. Method: Thirty experimental rabbits used for this study were randomized into five groups (A to E) of six rabbits. Rabbits in groups A to D were given salt lo…

Makoshi MS et al, Safety evaluation of Acalypha wilkesiana in albino rats & BHK-21 cell line Comparative Clin Pathology. 2016.

Fawehinmi AB et al, Formulation a& Evaluation of Anti-Dermatophyte Creams from Ethanol Extract of Acalypha wilkesiana Leaves. JSM Clin Cyto Pathol 3 : 5-2019 Abstract : The aim of this study was to formulate herbal antifungal cream containing extract of Acalypha wilkesiana as an antidermatophytic preparation & evaluate its physicochemical properties, stability & efficacy of the product. The formulated creams containing 0.5, 1 & 2% w/w of extract were subjected to stability tests using temperature variation method at -10, 4, 30, 37 & 45oC. Freeze-thaw test, Centrifuge test, pH & exposure to …

Igwe KK et al, Studies on the Medicinal Plant Acalypha wilkesiana ethanol Extract Phytocomponents by GCMS Analysis, Global J of Sci Frontier Res, 3 :4, 2016-ABSTRACT: The ethanolic extract of the leaves of Acalypha wilkesiana plant was studied to find the phytochemical compounds using GCMS analysis. The result of the phytochemical analysis revealed the presence of 12 compounds. Among the 12 compounds, the most abundant were 2-Ethyl-1-hexene with 39.21 peak area %, RT 22.698 & molecular formula C8H16 ; n-Hexadecanoic acid or palmitic acid with 20.92 peak area %, RT:20.92 & molecular formula …

Ike Wuchi JC et al, Hepatoprotective effect of an aqueous extract of the leaves of Acalypha wilkesiana ‘godseffiana’ Muell Arg. (Euphorbiaceae) against carbon tetrachloride induced liver injury in rats. Excli Journal. 2011; 10:280-9.

Kingsley O et al, Phytochemical, proximate & elemental analysis of acalypha wilkesiana leaves, Sci J of Pure & Applied Sci, 2;9, 2013-Abstract: Acalypha wilkesiana, commonly called Irish petticoat, is native to the south pacific islands & belongs to the family Euphorbiaceae. Apart from its use as a vegetable, theplant is also used in traditional medicine as a diuretic plant &  is eaten in the management of hypertension. In this study, three samples (ethanol extract,aqueous extract and dried powder) of A wilkesiana leaves were analyzedfor the presence of phytochemicals according to standard …

Olaribigbe M S et al, Formulation of Acalypha Wilkesiana Muell. Arg. Ethanol Leaf Extract into Creams for the Treatment of Microbial Skin Infections, Inter J of Pharmaceut Sci Invention, 3 :10, 2014-ABSTRACT: Acalypha wilkesiana leaf has been used by the local populace for the treatment of skin diseases for ages. Ethanol extract of the dried leaves of A wilkesiana was investigated for in vitro antimicrobial activities by agar diffusion & broth dilution techniques using Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi & a dermatitis fungus, Candida albicans. Strep…

SANTIAGO C et al, Reversal of Ampicillin Resistance in MRSA via inhibition of Penicillin-binding protein by Acalypha Wilkesiana, Biomed Res Int, 7, 2014.-Abstract: The inhibitory activity of a semi pure fraction from the plant, Acalypha wilkesiana assigned as 9EA-FC-B, alone and in combination with ampicillin, was studied against methicillin-resistant Staphylococcus aureus (MRSA). In addition, effects of the combination treatment on PBP2a expression were investigated. Microdilution assay was used to determine the minimal inhibitory concentrations (MIC). Synergistic effects of 9EA-FC-B with …

OKOKON et al, Antiulcerogenic Activity of Ethanolic Leaf Extract of Acalypha wilkesiana, Asian J of Pharmaceut & Biol Res, 1(4):464 -8, 2011.-Abstract: Acalypha wilkesiana Mull. Arg. is often used in traditional medicine by Ibi bios of Niger Delta region of Nigeria for the treatment of several diseases including Gastrointestinal disorders especially ulcer. Methods: In this study, the antiulcer activity of the ethanolic extract of the crude leaf extract was investigated against indomethacin, ethanol and histamine – induced ulcer models in rats. Results: The crude leaf extract of A. wilkesian…

Omage K et al, Medicinal Potential of Acalypha wilkesiana leave, Adv. in Res, 2(11):655-65, 2014.-Conclusion: comparatively, ethanol is a better extraction solvent than water. This may be due to the fact that most of the phytochemicals are more soluble in ethanol than in water. Hence, they are more readily extracted by ethanol than water. The plant (Acalypha wilkesiana) studied here can be seen as a potential source of useful drugs.

Olayinka MO et al, Inhibitory effects of oil extract of green Acalypha (Acalypha wilkesiana) on antioxidant and neurotransmitter enzymes in Callosobruchus maculatus, The J of Basic & Applier Biol, 80:1, 2019-abstract: Callosobruchus maculatus is an important insect pest of cowpea. The inhibitory effects of oil extract of Acalypha wilkesiana (Muell Arg.) leaves on antioxidant, neurotransmitter, and detoxifying enzyme in adult Callosobruchus maculatus (Fabricius) were evaluated under laboratory condition. The leaves of the plant were collected fresh and air-dried before the oil was extracted …

Omage K et al, Toxicological implications of the therapeutic use of Acalypha wilkesiana leaves in traditional medicine, Inter J of Phytomed & Phytother, 2017, 3:15 -Abstract: In traditional medicine, Acalypha wilkesiana is frequently used solely or as a composite part of many herbal preparations for therapeutic purposes. This study was therefore conducted to evaluate the effects of oral administration of extracts of Acalypha wilkesiana leaves, on some serum diagnostic enzymes in normal experimental rabbits. Methods: Eighteen adult male experimental rabbits were randomized into three groups …

Owoyele B et al, Antiinflammatory & antipyretic effects of the ethanol extract of Acalypha wilkesiana leaves in rats. Montréal, 13th World Congress on Pain; 2010.-Abstract: The leaves of Acalypha wilkesiana are commonly used for the treatment of pain, fever and ulcer by traditional medical practitioners without any scientific data to evaluate the appropriateness of some of the practices. Therefore, this study was carried out to determine whether the ethanol extract of A. wilkesiana has analgesic, anti-inflammatory & antipyretic as well as antiulcer effects. The hot plate latency assay and f…

Oyebode OE et al, Acalypha Wilkesiana ‘Java White’: Identification of Some Bioactive Compounds by GC-Ms & Their Effects on Key Enzymes Linked to Type 2 Diabète, Acta Pharma, 68: 425-39, 2018.-Abstract: In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark & root bark of Acalypha wilkesiana through GC-MS analysis & investigated the effects of these extracts on some of the enzymes linked to type 2 diabetes. Plant parts were extracted sequentially with ethyl acetate, ethanol & water. GC-MS analysis revealed the presence of long-chain alkyl acids,…

Udobang JA et al, Analgesic & antimalarial activities of crude leaf extract & fractions of Acalypha wilkesiana, J of Ethnopharmacol, 2010; 127:  373–8-Abstract: Antiplasmodial & analgesic activities of leaf extract & fractions of Acalypha wilkensiana were evaluated to ascertain the folkloric claim of its antimalarial a& analgesic activities. The crude leaf extract (220-659 mg/kg) & fractions (chloroform & aqueous; 440 mg/kg) of Acalypha wilkensiana were investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice and for analgesic activity aga…

Adesina SK et al, antimicrobial constituents of the leaves of Acalypha wilkesiana &Acalypha Hispida. Phytother Res 2000; 14:371-4.

Awe FA et al, Antibacterial Activity of Ethanolic Extract of Acalypha wilkesiana & Peperomia pellucida on Fish Pathogens, Inter J of Trend in Res & Dev, 4(3), ISSN: 2394-9333. -Abstract: The study was conducted to investigate the antibacterial activity of ethanolic extract of Acalypha wilkesiana & Peperomia pellucida leaves against Catfish infected with bacterial fin-rot. The menace of fin-rot in Fingerlings of Clarias gariepinus is becoming high and this can impair on fish productivity. Agar well diffusion assay was used and Whatman filter paper soaked in plant extracts was placed on inocu…

Babatunde S et al, Comparative effectiveness of chemical biocides & Acalypha wilkesiana leaf extract against postharvest fungal deteriogens of sweet orange (Citrus sinensis) fruits, Eur J of Applied Sci, 2017.

DIN W et al, Antioxidant & Cytoprotective Effects of an Ethanol extract of Acalypha wilkesiana var. macafeana from Malaysia. Nat Prod Commun, 8(3): 375-80, 2013.-Abstract: In the Annals of Biomedical theory perhaps no single class of natural product has enjoyed more ingenious speculation than antioxidants formally aimed at counteracting oxidative insults which are involved in the pathophysiology of Alzheimer's and Parkinson's disease, cancer, amyotrophic lateral sclerosis, skin ageing and wound healing. In pursuing our study of Malaysian traditional medicines with antioxidant properties, we…