Andrographis paniculata (Lachirèt) : vertus médicinales en extraction alcoolique

LOHAR S et al, Hepatoprotective activity of polyherbal tablet containing Andrographis paniculata & Tephrosia purpurea extracts against paracetamol-induced toxicity in rats, AIMS, Mol Sci, 13(1) :10-22, 2026

Singh TB et al, Phytochemical evaluation & molluscicidal activity of Andrographis paniculata, Herba Polonica, 56:4, 2010.

HARTANI D, THE PHARMACOGNOSTIC STANDARDS, ANTIOXIDANT ACTIVITY, & HEPATIC SAFETY PROFILE OF AN INDONESIAN ANTIDIABETIC POLYHERBAL FORMULATION, Indonesian Jl of Pharm, 2022-Abstract: This study evaluated the selected pharmacognostic characters, antioxidant activities, total phenolic content, & the hepatic safety of a polyherbal formulation containing seven plant constituents used by Klinik Wisata Kesehatan Jamu Kalibakung, Tegal, Indonesia, to treat diabetes patients.

CHAO WW et al, Isolation & identification of bioactive compounds in Andrographis paniculata (Chuanxinlian), Chin Med, 5:17, 2010-Abstract: Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a medicinal plant used in many countries. Its major constituents are diterpenoids, flavonoids & polyphenols. Among the single compounds extracted from AA andrographolide is the major one in terms of bioactive properties and abundance. Among the andrographolide analogues, 14-deoxy-11,12-didehydroandrographolide is immunostimulatory, anti-infective & anti-atherosclerotic; neo-andrographolide is anti-…

BALAP A et al, Herb-drug interaction of Andrographis paniculata (Nees) extract & Andrographolide on pharmacokinetic &d pharmacodynamic of Naproxen in rats. Jl Ethnopharmacol. 2017, 4;195:214-21.-Abstract: Andrographis paniculata Nees (Acanthaceae) have broad range of pharmacological effects such as hepatoprotective, antifertility, antimalarial, antidiabetic, suppression of various cancer cells & anti-inflammatory properties & is widely used medicinal plant in the traditional Unani & Ayurvedic medicinal systems. Andrographolide (AN) is one of the active constituents of the A. paniculata Nees…

BALAP A et al, Pharmacokinetic & Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats. Phytother Res. 2017;31(1):75-80.-Abstract: The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) & Andrographolide (AN) with Nabumetone (NAB) in Wistar rats. Pharmacokinetic & pharmacodynamic interactions were studied after co-administration of APE & AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t & AUC0-∞ of 6-MNA after …

BALAP A et al, Herb-drug interaction of Andrographis paniculata (Nees) extract & Andrographolide on pharmacokinetic &d pharmacodynamic of Naproxen in rats. Jl Ethnopharmacol. 2017, 4;195:214-21.-Abstract: Andrographis paniculata Nees (Acanthaceae) have broad range of pharmacological effects such as hepatoprotective, antifertility, antimalarial, antidiabetic, suppression of various cancer cells & anti-inflammatory properties & is widely used medicinal plant in the traditional Unani & Ayurvedic medicinal systems. Andrographolide (AN) is one of the active constituents of the A. paniculata Nees…

BALAP A et al, Pharmacokinetic & Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats. Phytother Res. 2017;31(1):75-80.-Abstract: The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) & Andrographolide (AN) with Nabumetone (NAB) in Wistar rats. Pharmacokinetic & pharmacodynamic interactions were studied after co-administration of APE & AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t & AUC0-∞ of 6-MNA after …

BALAP A et al, Pharmacokinetic & Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats. Phytother Res. 2017;31(1):75-80.-Abstract: The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) & Andrographolide (AN) with Nabumetone (NAB) in Wistar rats. Pharmacokinetic & pharmacodynamic interactions were studied after co-administration of APE & AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t & AUC0-∞ of 6-MNA after …

BALAP A et al, Herb-drug interaction of Andrographis paniculata (Nees) extract & Andrographolide on pharmacokinetic &d pharmacodynamic of Naproxen in rats. Jl Ethnopharmacol. 2017, 4;195:214-21.-Abstract: Andrographis paniculata Nees (Acanthaceae) have broad range of pharmacological effects such as hepatoprotective, antifertility, antimalarial, antidiabetic, suppression of various cancer cells & anti-inflammatory properties & is widely used medicinal plant in the traditional Unani & Ayurvedic medicinal systems. Andrographolide (AN) is one of the active constituents of the A. paniculata Nees…

Woo AY et al, Andrographolide upregulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia/reoxygenation injury. Jl of Pharmacol & Experiment Therapeutics 325, 226–35, 2008.

Sirisha MNVL et al, Isolation of Diterpenoid Lactones from the Leaves of Andrographis Paniculata & Its Anticancer Activity. Inter Jl of Pharmacogn & Phytochem Res 3:39-42, 2011.

Kumarappan C et al, Antihaemolytic & snake venom neutralizing effect of some Indian medicinal plants, Asian Pacific Jl of Trop Med, 4(9):743-7, 2011-Abstract: To validate traditional claims of usefulness of the Indian plants in management of poisonous snakebite & evaluate the Antivenom properties displayed by the alcoholic extracts of Andrographis paniculata, Crataeva magna (C. magna), Gloriosa superba & Hydrocotyle javanica. Methods: These plants were collected; identified & the extracts were prepared by using conventional Soxhlet ethanol extraction technique. The venom neutralization acti…

Zakaria Z et al, In vitro studies of Asian medicinal plants with potential activity against breast cancer, Jl of Applied Biol & Biotechnol, 6(04) :49-55, 2018.-Abstract: Breast cancer is the most common cause of cancer in women, and the side effects reported for conventional treatments have motivated scientists to investigate the anticancer properties of natural products such as medicinal plants. This review summarizes the in vitro studies on medicinal plants available in Asian countries, including Aloe vera, Alpinia galanga, Centella asiatica, Andrographis paniculata, Curcuma longa, Morind…

BOSCO F et al, The Effects of Andrographis paniculata (Burm.f.) Wall. Ex Nees & Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases, Nutrients, 15(15):3428.2023-Abstract: Neurodegenerative diseases (NDs) affect millions of people worldwide, & to date, Alzheimer's & Parkinson's diseases are the most common NDs. Of the many risk factors for neurodegeneration, the aging process has the most significant impact, to the extent that it is tempting to consider neurodegenerative disease as a manifestation of accelerated aging. However, genetic & environmental factors …

GONG P et al, Andrographolide Attenuates Blood-Brain Barrier Disruption, Neuronal Apoptosis, & Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage, Neurotox Res, 40(2):508-519.2022-Abstract: Andrographolide (Andro), a diterpene of the labdane family extracted from the Asian plant Andrographis paniculata, is neuroprotective against stroke & Alzheimer's disease. However, whether Andro protected the brain against subarachnoid hemorrhage (SAH) was still unknown. Thus, we explored whether Andro attenuated blood-brain barrier (BBB) disruption & neuronal a…

Fatmawathi A et al, Combination Effects of Moringa oleifera Leaf Ethanol Extract & Andrographis paniculata Herb on Blood Glucose Levels & Pancreas Histopathology of Diabetic Rats Induced by Streptozotocin, Majalah Obat Tradisional 24(2):85, 2019-Abstract:Type 2 diabetes mellitus is a non-contagious disease, can damage the glucose metabolic system in the body, & is characterized by hyperglycemic conditions. Moringa leaves (Moringa oleifera) & Andrographis herbs (Andrographis paniculata) have been studied to have antihyperglycemic activity in diabetic rats. The purpose of this study was to de…

Komai-Kul J et al, Effect of andrographolide & deep eutectic solvent extracts of Andrographis paniculata on human coronavirus organ culture 43 (HCoV-OC43), Phytomed, 112:1540708, 2023-Abstract: Andrographis paniculata (Burm. f.) Nees has demonstrated potential for treating infections caused by coronaviruses. However, no antiviral activity of andrographolide or AP extracts against human coronavirus organ culture 43 (HCoV-OC43) has been reported. Purpose: This study aimed to evaluate the anti-HCoV-OC43 effect of andrographolide & AP as well as the correlation between andrographolide concentra…

KERDSIRI J et al, In silico & Bioassay-guided identification of potential anti-SARS-CoV-2 tentative candidate compounds from Andrographis paniculata extract, Comput & Struct Biotechnol, 27: 2025-Abstract: COVID-19, caused by the SARS-CoV-2 virus. This infectious disease significantly targets the upper & lower respiratory tracts of humans and animals. The mechanisms of SARS-CoV-2 infection are crucially mediated by specific viral proteins, such as the spike protein, as well as various enzymes, including proteases & transferases, & host proteins, including the ACE2 receptor. These proteins fa…

LEE et al, Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangial cell lines, Jl of Ethnopharm, 132 :497-505, 2010--Abstract: Extracts of Andrographis paniculata Nees are used for various ethnomedical conditions including hyperglycemia & hypertension complications. Aim of the study: The purpose of this study is to evaluate the Anti-diabetic nephropathy effect of diterpene lactones andrographolide (AP1) a&14-deoxy-11,12-didehydroandrographolide (AP2) from A paniculata. Materials …

ZHANG D et al, Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway, JL Basic Med Sci, 2023;26(6):653-61-Abstract: Paraquat (PQ), a highly effective &rapidly non-selective herbicide, mainly targets the lungs & causes acute lung injury (ALI). So far, the scarcity of effective drug candidates against PQ-induced ALI remains a big challenge. Andrographolide (Andro), with its anti-inflammatory & antioxidant activities, has been demonstrated to alleviate ALI. Nevertheless, whether Andro could alleviate the PQ-mediated ALI remains unknown. Therefore, th…

LI Z et al, Andrographolide contributes to spinal Cord injury repair via inhibition of apoptosis, oxidative stress & inflammation, Front Pharmacol, 13:949502. 2022-Abstract: Spinal cord injury (SCI) is a common disorder of the central nervous system with considerable socio-economic burden. Andrographolide (Andro), the main active component of Andrographis paniculata, has exhibited neuroprotective effects in different models of neurological diseases. The aim of this study was to evaluate the neuroprotective effects of Andro against SCI & explore the related mechanisms. Methods: SCI was induc…

Kothandan G et al, GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS & DOCKING STUDIES OF ANDROGRAPHIS PANICULATA AGAINST DENGUE FEVER, Semantic Scholars, 2018-Abstract: The nine compounds obtained from the ethanol extract of A. paniculata were characterized & docked. Among these nine compounds, vor-diazepam,3-[[N-hydroxy-methyl-] amino-carbonyloxy], dasycarpidan-1-methanol, acetate (ester), ethanol, 2-(9, 12-octadecadienyloxy)-, (Z, Z), & Gibb-2-ene-1,10-dicarboxylicacid4a,7-dihydroxy-1-methylene-1,4a-lactone,10 methyl ester, (1a,4aa, 4ba,10a) were found to show better interaction energeticall…

SUN LR et al, Extract from Dioscorea bulbifera L. rhizomes aggravate pirarubicin-induced cardiotoxicity by inhibiting the expression of P-glycoprotein & multidrug resistance-associated protein 2 in the mouse liver, Sci Rep, 11(1):19720. 2021-Abstract: Chinese herbal medicine is widely used because it has a good safety profile & few side effects. However, the risk of adverse drug reactions caused by herb-drug interactions (HDIs) is often overlooked. Therefore, the task of identifying possible HDIs & elucidating their mechanisms is of great significance for the prevention & treatment of HDI-r…

Zhang XF et al, Antihyperglycaemic & antioxidant properties of Andrographis paniculata in normal and diabetic rats. Lin Exp Pharm Physiol. 2000;27(5-6):358-63-Abstract. In the present study, we investigated the ethanolic extract of the aerial parts of Andrographis paniculata for anti-hyper-glycaemic and antioxidant effects in normal & streptozotocin-induced type I diabetic rats. 2. Normal & diabetic rats were randomly divided into groups & treated orally by gavage with vehicle (distilled water), metformin (500 mg/kg bodyweight) or the extract (400 mg/kg bodyweight), twice a day for 14 days.…

PAN YAN et al, In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19), Jl of Ethnopharm, 133 (2) :881-7, 2011-Abstract : Andrographis paniculata (AP), Centella asiatica (CA) & Orthosiphon stamineus (OS) are three popular herbs traditionally used worldwide. AP is known for the treatment of infections & diabetes and CA is good for wound healing & healthy skin while OS is usually consumed as tea to treat kidney and urinary disorders. Interaction of these herbs with human cytochrome P450 2C19 (CYP2C19), a major hepat…

Ziyadeh FN et al, Stimulation of collagen gene expression & protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor, Jl of Clin Investigations 93, 536–42, 1994.

SUBRAMANIAN R et al, Effect of Andrographolide & Ethanol Extract of Andrographis paniculata on Liver Glycolytic, Gluconeogenic, & Lipogenic Enzymes in a Type 2 Diabetic Rat Model, https://www.researchgate.net/publication/232035561-Abstract: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) (AP), containing the major active principle, Andrographolide, (AG) has been used ethnomedically in the treatment of diabetes & hypertension in Malaysia & India. Type 2 diabetes mellitus was induced by administering nicotinamide (NA) 180 mg/kg i.p. followed by streptozotocin (STZ) 45 mg/kg i.p. 15 min l…

Lindawati NY et al, The Effect of Combination from Purified Extract of Sambiloto Herb (Andrographis Paniculata (Burm.f.) Nees) & Pegagan Herb (Centella Asiatica (L.) Urban) Of Translocation of Glut-4 Protein in Type 2 Diabetes Mellitus-Insulin Resistance Rats. Tradit Med Jl, 19(2). 2014-Abstract: Sambiloto herb (Andrographis paniculata (Burm. f.) Nees.) & Pegagan herb (Centella asiatica (L.) Urban) are excellent medicinal plants which are being developed as traditional for antidiabetic. The research aims to see the effect of combination from purified extract of AP herb & CA of translocation…

Shi MD et al, Inhibition of cell cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chemico Biol Interactions 174, 201–10, 2008.

WANG DP et al, Andrographolide enhances hippocampal BDNF signaling & suppresses neuronal apoptosis, astroglial activation, neuroinflammation, & spatial memory deficits in a rat model of chronic cerebral hypoperfusion, Naunyn Schmiedebergs Arch Pharmacol, 392(10):1277-1284.2019-Abstract: Andrographolide is a medical herbal compound with documented anti-inflammatory activity & therapeutic efficacy in animal models of Alzheimer's disease, traumatic brain injury, & ischemic stroke. The present study examined the potential therapeutic effects of andrographolide on chronic cerebral hypoperfusion …

RAJESHKUMAR S et al, ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA LEAVES EXTRACT AGAINST NEUROBLASTIMA (IMR-32) & HUMAN COLON (HT-29) CANCER CELL LINE, World Jl of Pharm & Pharmaceut Sci, 4(06) :25-75, 2015-Abstract: In this report, we studied the Invitro anticancer properties of Andrographis paniculata leaves against neuroblastoma (IMR-32) & human colon (HT-29) cancer cell line. The leaves were shade dried & extracted with water, ethanol & acetone solvents. Anticancer property of A. paniculata leaf extract was analyzed by Spectrophotometric MTT assay method. The results were found that e…

WANG DP et al, Neuroprotective effects of andrographolide on chronic cerebral hypoperfusion-induced hippocampal neuronal damage in rats possibly via PTEN/AKT signaling pathway, Acta Histochem, 122(3):151514, 2020-Abstract: to study the effects of andrographolide on chronic cerebral hypoperfusion (CCH)-induced neuronal damage as well as the underlying mechanisms. Rat CCH model was established by 2-vessel occlusion (2VO). The CCH rats received andrographolide treatment for 4 weeks. The neuron loss was detected by using neuronal nuclei (NeuN) immunofluorescent staining. The expression levels o…

Chun JY et al. andrographolide, an herbal medicine, inhibits interleukin-6 expression & suppresses prostate cancer cell growth, Genes Cancer, 1(8):868-76, 2010-Abstract: Elevated interleukin-6 (IL-6), a major mediator of the inflammatory response, has been implicated in androgen receptor (AR) activation, cellular growth & differentiation, plays important roles in the development & progression of prostate cancer, & is a potential target in cancer therapy. Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lact…

Warditiani N K et al, Antiatherosclerosis Effect of Purified Andrographis paniculata Extract, Thailand 4° Int Conf on Pharm & Pharmaceut Sci, 8(5):2015-Abstract: the antiatherosclerosis effect of purified Andrographis paniculata extract (PAE) was studied on atherosclerotic Wistar male albino rats. A fat-rich diet containing 10% yolk, 15% fat of pig, 1% calcium, 20,000 IU vitamin D3 was administered to albino male Wistar rats for 60 days to induce atherosclerosis. The two groups’ atherosclerosis rats were treated orally with PAE for 30 days at doses of 24 a&70 mg/kg body weight, respectively…

Kaushik S et al, Identification & characterization of new potent inhibitors of dengue virus NS5 proteinase from Andrographis paniculata supercritical extracts on in animal cell culture & in silico approaches, Jl Ethnopharmacol, 267:113541. 2021-Abstract:  The whole plant of Andrographis paniculata used traditionally over past decades for health promotion. Andrographolide isolated from AP is used as natural remedy for the treatment of various diseases in different parts of the world. Andrographolide has been reported to have antiviral activity against hepatitis B virus, hepatitis C virus, he…

Akbarsha MA et al, Aspects of the male reproductive toxicity/male antifertility property of Andrographolide in albino rats: effect on the testis & the cauda Epididymal spermatozoal. Phytother Res 2000;14(6):432-5-Abstract: Previous work has shown that Andrographis paniculata leaf, when fed to male albino rats, causes the arrest of spermatogenesis. The present study was undertaken to investigate whether andrographolide, one of the major constituents of this plant, is responsible for such an effect. The compound was administered to 3-month-old male Wistar albino rats at two dose levels, for 4…

Kishore V et al, Inhibition of group IIA secretory phospholipase A & its inflammatory reactions in mice by ethanolic extract of Andrographis paniculata, a well-known medicinal food. Phcog Res 2016; 8:213-6- Abstract: Andrographis paniculata Nees is an important medicinal plant found in the tropical regions of the world, which has been traditionally used in Indian & Chinese medicinal systems. It is also used as medicinal food. AP is found to exhibit antiinflammatory activities; however, its inhibitory potential on inflammatory Group IIA phospholipases A2(PLA2)&d its associated inflammatory r…

ISLAM A et al, In-silico study unveils potential phytocompounds in Andrographis paniculata against E6 protein of the high-risk HPV-16 subtype for cervical cancer therapy, Sci Rep, 14(1):17182, 2024-Abstract: Despite therapeutic advancements, cervical cancer caused by high-risk subtypes of the human papillomavirus (HPV) remains a leading cause of cancer-related deaths among women worldwide. This study aimed to discover potential drug candidates from the Asian medicinal plant Andrographis paniculata, demonstrating efficacy against the E6 protein of high-risk HPV-16 subtype through an in-silic…

Jadav AK et al, Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties Phytother Res, 35(10):5365-73, 2021-Âbstract: Andrographis paniculata is home to a rich variety of molecules especially andrographolide & its derivatives. Clinical properties of the andrographolide are multifarious and include: analgesic, antipyretic, antiretroviral, antiproliferative, antimalarial, antithrombotic, antihyperglycemic, antiurolethial, antilesihmaniasis, hepatoprotective, immune-modulatory, protective against alcohol induced toxicity & cardioprotective activity & anticancer activity. Andrograp…

Zhou J et al, Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochem Pharmacol 79, 1242–50, 2010.

Gonde DP et al, Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, & pharmacology, Ann Pharm FR, 82(1):15-43, 2024-Abstract: Andrographis paniculata (Kalmegh) is also known as "king of bitters", is an herbaceous plant belongs to family Acanthaceae. The therapeutic effect is due to presence of diterpenoid lactone derivatives of AP mainly andrographolide. The main purpose of this review includes detailed (past & present) study of AP & its most important component andrographolide a diterpenoid lactone with respect …

Huang TK: Handbook of compositions & pharmacology of traditional Chinese medicine; Beijing: China Medical & Technol Press, 1994.

Kumar S et al, Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties & quality control/quality assurance, Jl of Ethnopharmacol, 2021-Abstract: Andrographis paniculata (Burm.f.) Nees is a medicinal herb of the Asian countries used in many traditional medicinal systems for the treatment of diarrhea, flu, leprosy, leptospirosis, malaria, rabies, upper respiratory infections, sinusitis, syphilis, tuberculosis and HIV/AIDS etc. AIM OF THE STUDY: This review aims to provide the comprehensive, accurate & authentic information on traditional uses, phyt…

Mkrtchyan A et al A phase I clinical study of Andro. Paniculata fixed combination Kan Jang versus ginseng and Valerian on the Semen quality of healthy male subjects. Phytomed 2005;12(6-7):403-9.

Prabha N et al, Gas Chromatography Mass Spectrometry Analysis of Andrographis paniculata. Asian Jl. Research Chem. 12(1): 01-06. 2019-

Saxena S, Chemistry & pharmacology of Andrographis species. Indian Drugs. 1998; 35:458-67.

Rao YK et al, Flavonoids & andrographolides from Andrographis paniculata. Phytochem, 65, 2317–21, 2004.

Agbonlahor O et al, Harnessing the medicinal properties of Andrographis paniculata for diseases & beyond: a review of its Phytochemistry & Pharmacology. Asian Pac Jl Trop Dis 2014; 4(3): 213-22.

Niranjan A et al, biological activities of Kalmegh (Andrographis paniculata Nees) & its active principles: A review. Indian Jl Nat Prod Res 2010; 1:125-35.

Puspitasari A et al, Optimization of Extraction Process & Dechlorophyllation of Ethanolic Extract of Andrographis Paniculata Ness, Thailand 4° Int Conf on Pharm & Pharmaceut Sci, 8(5):2015-Abstract: In the recent development, natural product industry has utilized extracts as raw material despite crude drugs. This phenomenon is due to the simplicity of extract to formulate & standardize. In order to enhance the effectiveness & efficiency, it is necessary to optimize extraction process which produces extract with high active compound content. Andrographis paniculata has been widely used in tr…

Zhao J et al, Determination of Andrographolide, deoxy-andrographolide & neoandrographolide in the Chinese herb Andrographis paniculata by micellar electrokinetic capillary chromatography. Phytochem Anal. 2002;13 (4): 222-7-Abstract: In this paper a micellar electrokinetic capillary chromatographic (MEKC) method has been developed for determining the active components (Andrographolide, deoxy-andrographolide & neoandrographolide) in water: ethanol extracts of the Chinese crude herb Andrographis paniculata & its preparations (Chuan xin Lian &X Xiaoyan Lidan tablets). The optimum separation con…

Vasantha S et al, Gas Chromatography‐Mass Spectrometry (GC‐Ms) Analysis of Ethanolic Leaf Extract of Andrographis paniculata Nees. Int Jl Med Biosci. 2(1): 16 ‐207, 2013-abstract: Andrographis paniculata is traditionally used for treating different aliments. The present investigation was carried out to determine the possible chemical components from Andrographis paniculata by GC-MS technique. This analysis revealed that the ethanol extract contains 2,5-Octa-decadiynoic acid, methyl ester(27.83%), 1,2,3,5-Cyclohexanetetrol, (1à,2á,3à,5á)-(14.78%), 10-12-Pentacosadiynoic acid(12.25%), 2H-Pyr…

Jarukamjorn K et al. Pharmacological aspects of Andrographis paniculata on Health & its major diterpenoid constituent Andrographolide. Jl. Health Sci. 2008, 54, 370-81.

POMPICHANARONG C et al, Development & Optimization of Andrographis paniculata Extract-Loaded Self-Micro Emulsifying Drug Delivery System Using Experimental Design Model, Pharmaceutics, 16(2):166, 2024-Abstract: the objective of this study was to develop an optimized formulation for an Andrographis paniculata extract (AGPE)-loaded self-micro emulsifying drug delivery system (SMEDDS) using an experimental design & evaluate the characteristics of the developed SMEDDS. The solubility of andrographolide (AGP) in various solvents was investigated. The pseudo-ternary phase was constructed to provi…

Mishra SK et al, Andrographis paniculata (Kalmegh): A review. Pharmacogn Rev 2007; 1:283-98.

TABBOON P et al, Intestinal Permeation Characteristics via Non-Everted Gut Sac of Diterpene Lactones from Pure Andrographolide & Three Different Andrographis Extracts: An Investigation into Liqui-Mass with Different Solvents, Pharmaceut, 18(1):90, 2026-Abstract:This study aimed to assess the intestinal permeation behaviors of andrographolide (AG) & 14-deoxy-11,12-didehydro-andrographolide (DDAG), diterpene lactones from Andrographis paniculata extract (APE), pure AG, & three distinct source APEs. The effects of different solvents were also investigated. Methods: Solubility investigation was…

Sreevani, P, Phytochemical & pharmacological activities of Andrographis Paniculata Nees.: A Review. Inter Jl of Sci & Res, 1887-90 2013-

Radhika P et al, Antiinflammatory activity of chloroform extract of Andrographis paniculata Nees Stem. Res Jl Biotechnol 2009; 4:35-8.

YUE GGL et al, Multiple modulatory activities of Andrographis paniculata on immune responses & xenograft growth in esophageal cancer preclinical models, Phytomed, 60:152886. 2019-Abstract:  Esophageal cancer (EC) is a malignant gastrointestinal cancer w high morbidity worldwide & is the fourth leading cause of cancer-related deaths in China. Even though surgery and/or chemotherapy/chemoradiation might achieve good therapeutic response, recurrence rate is high due to cancer metastasis. Hence, the use of alternative adjuvant treatments, such as herbal medicines, for metastatic EC remains a gr…

AL-KHAYRI JM et al, In Silico Identification of 1-DTP Inhibitors of Corynebacterium diphtheriae Using Phytochemicals from Andrographis paniculata, Mol, 28(2):909. 2023-Abstract: A number of phytochemicals have been identified as promising drug molecules against a variety of diseases using an in-silico approach. The current research uses this approach to identify the phyto-derived drugs from Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) for the treatment of diphtheria. In the present study, 18 bioactive molecules from AP (obtained from the PubChem database) were docked against the di…

Kumar RA et al: Anticancer & immunostimulatory compounds from Andrographis paniculata, Jl of Ethnopharmacol, 2004; 92(2-3): 291-ABSTRACT: Andrographis paniculata extract is traditionally used as a medicine to treat different diseases in India, China & Southeast Asia. In the present study, we evaluated the anticancer & immunomodulatory activity of the methanolic extract of AP in human cancer & immune cells. The methanolic extract of AP was fractionated into dichloromethane, petroleum ether & aqueous extracts & screened for bioactivity. Our results indicate that the dichloromethane fraction o…

Siripong G et al, Cytotoxic diterpenoid constituents from Andrographis paniculata Nees leaves. Jl Sci Soc Thailand 1992; 18:187-94.

PETRUS RISKY P et al, PENGARUH KOMBINASI DAUN STEVIA (STEVIA REBAUDIANA BEST) & EKSTRAK ETANOL DAUN SAMBILOTO (ANDROGRAPHIDIS FOLIUM) TERHADAP STRESS OKSIDATIF PADA TIKUS DIABETES MILITUS YANG DIINDUKSI ALOXAN, Jl Kusuma Husada, 2017-Abstract: Diabetes Mellitus ABSTRACT Global Diabetes Statistic reports that in 2003 there were 194 million people in the world suffering from DM & would increase to 333 million by 2025. The hyperglycemic state is also involved in the free radical free radical process which is marked by elevated levels of lipid peroxide (LPO) & decreased Glutathion (GSH). Treatm…

WAHYUNI LET ert al, The Effect of Administering Herbal Extract Of Sambiloto Leaves (Andrographis Paniculata) On Blood Sugar Levels In Male White Rats (Rattus Norvegicus) Induced by alloxan, The Indonesian Jl of Med Lab Tech, 1(1):20-7, 2024-Abstract: Currently, people prefer alternative treatments using herbal medicines because they have few side effects & are easy to obtain both in terms of price & availability. Sambiloto (Andrographis paniculata Ness) is a traditional medicine used by Indonesians to lower blood glucose because it contains andrographolide & flavonoids. Objectives & Method…

BALAP A et al, Pharmacokinetic & Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats. Phytother Res. 2017;31(1):75-80.-Abstract: The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) & Andrographolide (AN) with Nabumetone (NAB) in Wistar rats. Pharmacokinetic & pharmacodynamic interactions were studied after co-administration of APE & AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t & AUC0-∞ of 6-MNA after …

LI H et al, Mechanism of Andrographis paniculata on lung cancer by network pharmacology and molecular docking, Technol Health Care, 31(4):1407-27. 2023-Abstract: Traditional Chinese medicine (TCM) has been widely recognized & accepted worldwide to provide favorable therapeutic effects for cancer patients. As Andrographis paniculata has an anti-tumor effect, it might inhibit lung cancer. Objective: The drug targets & related pathways involved in the action of Andrographis paniculata against lung cancer were predicted using network pharmacology, & its mechanism was further explored at the mol…

Jiang M et al, Andrographis paniculata (Burm.f.) Nees & its major constituent andrographolide as potential antiviral agents, Jl of Ethnopharmacol, 272:113954, 2021-Abstract: Andrographis paniculata (Burm.f.) Nees is widely used all over the world, especially in subtropical regions such as India, Thailand, Vietnam, & China. As a traditional folk Chinese medicine, A. paniculata has been extensively utilized for the treatment of cold, fever, sore throat, cough, carbuncle, and sores, and it is commonly employed for 'clearing heat and resolving toxicity'. Typical symptoms of 'heat and toxicity' …

THAKUR AK et al, Beneficial effects of an Andrographis paniculata extract & andrographolide on cognitive functions in streptozotocin-induced diabetic rats, Biol, 54(9):1528-38. 2016- Abstract Andrographolide containing Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae) extracts is often used for treatments of diabetes and other inflammatory disorders commonly accompanying cognitive & other psychiatric disorders. Objective To compare the efficacies of a standardised A. paniculata extract (AP) & pure andrographolide on cognitive functions, oxidative stress & cholinergic function i…

Sheeja K. et al, Activation of cytotoxic T lymphocyte responses & attenuation of tumor growth in vivo by Andrographis paniculata extract & andrographolide. Immunopharm & Immunotoxicol 29, 81–93, 2007-Abstract: The stimulatory effect of Andrographis paniculata extract & andrographolide on cytotoxic T lymphocyte (CTL) production was determined in BALB/c mice by Winn's neutralization assay using CTL sensitive EL4 thymoma cells as target cell. Extract and andrographolide showed a significant increase in CTL production in both the in vivo and in vitro models. The survival time of EL4 cells alone…

TERHEMEN MM et al, Neuropharmacological potentials (antipsychotic-, anxiolytic-, & antidepressant-like activities) of methanol leaf extract of Andrographis paniculata Nees in vivo: Possible mechanisms, antioxidant activity, & in silico supportive evidence, JL of Ethnopharmacol, 355(Pt A):120653. 2026--Abstract: In Asia & parts of Africa, extracts from Andrographis paniculata Nees (Acanthaceae) are used as traditional remedies for a number of ailments such as tuberculosis, sinusitis, syphilis, leprosy, diarrhea, & malaria. There has been extensive research detailing the various pharmacologic…

Robbani S et al, Alpha-glucosidase & DPP-IV Inhibitory Activities of Ethanol Extract from Caesalpinia sappan, Andrographis paniculata, & Syzygium cumini. Pharmacogn Jl. 2022;14(3): 702-9-Abstract: Diabetes is one of the fastest-growing global health problems of the 21st century. Antidiabetic medicine has been widely marketed with various mechanisms of action. However, there are side effects from these drugs. Therefore, most diabetic patients consume herbal as complementary. Plants that have been shown to have potential as an antidiabetic are Caesalpinia Sappan, Andrographis Paniculata & Syz…

LAPMANCE S et al, Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors & hippocampal damage in TNF alpha induced neuroinflammatory mice, Rep, 15(1):11939, 2025--Abstract: This study aimed to improve the delivery efficacy of andrographolide (Andro) by encapsulating it in nanostructured lipid carriers (NLCs) & to evaluate its effectiveness in reducing systemic inflammation. These Andro-NLCs exhibited homogeneity with a particle size of 131.40 ± 1.30 nm & approximately 89% encapsulation efficiency. Andro NLCs potentially enhanced oral efficacy by improving gastrointestinal…

FENG D et al, Exploring multifunctional components from Andrographis paniculata by affinity ultrafiltration with three molecular targets, Food Chem, 404(Pt A):134515. 2023-Abstract: Andrographis paniculata (Burm. F.) Nees (AP) was a typical plant resource that has the concomitant function of both foodstuff & medicine, while the action mechanisms of its immune regulation, anti-inflammatory & anti-viral effects & the specific components remain unclear. In this work, a screening approach combining bio-affinity ultrafiltration with liquid chromatography mass spectrometry (UF-LC/MS) was hired to…

Chien CF et al, Herb-drug interaction of Andrographis paniculata extract & Andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact. 2010;184(3):458-65-Abstract: Herb-drug interaction has become a serious problem since herbal medicine is extensively used in the modern world. This study investigates effects of Andrographis paniculata extract (APE) and its major component, Andrographolide (AG), on the pharmacokinetics of theophylline, a typical substrate of cytochrome P450 1A2 enzyme, in rats. After APE or AG pretreatment for 3 days, on the fourth day rats were admi…

Lin TP et al, Inhibition of the Epstein-Barr virus lytic cycle by Andrographolide. Biol Pharm Bull 2008, 31(11):2018-23-Abstract: Andrographis paniculata NEES is a medicinal plant that is commonly used in Asia. This work demonstrates that 25 microg/ml of ethanolic extract from A. paniculata (EEAP) & 5 microg/ml of Andrographolide, a bioactive compound in EEAP, effectively inhibit the expression of Epstein-Barr virus (EBV) lytic proteins, RTA, Zta and EA-D, during the viral lytic cycle in P3HR1 cells. Transient transfection analysis revealed that the lack of expression of RTA, Zta and EA-D i…

Adebayo BC et al, Effect of Andrographis paniculata leaves extract on neurobehavioral & biochemical indices in scopolamine-induced amnesic rats, Jl Food Biochem, 45(3): e13280, 2021-Abstract: Andrographis paniculata is a medicinal herb that is used to treat various disease conditions due to its pharmacological properties. Thus, this study sought to assess the effect of AP extract on neurobehavioral & some biochemical parameters in scopolamine-induced amnesic rats. Thirty-five male rats were divided into seven groups & treated with aqueous extract of A. paniculata (50 & 500 mg/kg) & donepezi…

GAYASUDIN MOUID M et al, Effect of Ethanolic Extract of Aerial Parts of Andrographis paniculata on the Pharmacokinetics of Gliclazide in Rats. Asian Jl of Biomed & Pharmaceut Sci, 5(51) :21-4, 2015- Abstract: The present study aims to find out any possible interaction between the herbal drug i.e., 60% ethanolic extract of aerial parts of Andrographis paniculata on the antidiabetic drug Gliclazide as these involve metabolic reactions using CYP2C9 & CYP3A4 enzymes .In this study, three groups of Albino Wistar rats of either sex were used of which Group –I was used to determine the spiked seru…

Yamagishi S et al, Advanced glycation end products inhibit de novo protein synthesis & induce TGF- over expression in proximal tubular cells. Kidney Inter, 63, 464–73, 2003.

Coon J et al, Andrographis paniculata in the Treatment of Upper Respiratory Tract Infections: A Systematic Review of Safety & Efficacy. Planta Med: 70(4) :293-8, 2004.

XIE H et al, Deciphering the potential anti-COVID-19 active ingredients in Andrographis paniculata (Burm. F.) Nees by combination of network pharmacology, molecular docking, & molecular dynamics, 11(58):36511-17.2021-Abstract: Currently, coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has posed an enormous threat to public health worldwide. An andrographolide sulfonates preparation, named Xiyanping injection in Chinese, which was prepared from the aqueous extract of Andrographis paniculata (Burm. F.) Nees, showed favorable therapeutic effectiven…

Cheung HY et al, Andrographolide isolated from Andrographis paniculata induces cell cycle arrest & mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Planta Med. 2005;71(12):1106 -Abstract: The in vitro cytotoxicities of the ethanol extract of Andrographis paniculata & its main diterpenoid components were evaluated in various cancer cells. APE was found to be significantly growth inhibitory to human acute myeloid leukemia HL-60 cells with an IC (50) value of 14.01 microg/mL after 24 h of treatment. Among the three main diterpenoids in AP, Andrographolide exhibited the highest d…

Radji M et al, Comparative antimycobacterial activity of some Indonesian medicinal plants against multi-drug resistant Mycobacterium tuberculosis, Jl App Pharm Sci. 2015; 5(1):19-22-Abstract: This study has been carried out to compare antimycobacterial activity of five selected Indonesian endogenous medicinal plants of Andrographis paniculata, Annona muricata, Centella asiatica, Pluchea indica, & Rhoeo spathacea against clinical isolate of multi-drug resistant (MDR) Mycobacterium tuberculosis. The aqueous extracts of leaves of Andrographis paniculata, Annona muricata, Centella asiatica, Plu…

SUBRAMANIAM S et al, Hepatoprotective effect of ethanolic extract of whole plant of Andrographis paniculata against CCl4-induced hepatotoxicity in rats, Comp Clin Pathol, 24(5) :1245-52, 2015-Abstract: Liver diseases pose a major challenge to international public health. Hepatic damage is associated with distortion of metabolic functions of the liver. The present study was carried out to evaluate the hepatoprotective effect of the ethanolic extract of whole plant of Andrographis paniculata in CCl4-induced hepatotoxicity in albino rats. Hepatotoxicity was induced in rats by single intraperit…

BALAP A et al, Herb-drug interaction of Andrographis paniculata (Nees) extract & Andrographolide on pharmacokinetic &d pharmacodynamic of Naproxen in rats. Jl Ethnopharmacol. 2017, 4;195:214-21.-Abstract: Andrographis paniculata Nees (Acanthaceae) have broad range of pharmacological effects such as hepatoprotective, antifertility, antimalarial, antidiabetic, suppression of various cancer cells & anti-inflammatory properties & is widely used medicinal plant in the traditional Unani & Ayurvedic medicinal systems. Andrographolide (AN) is one of the active constituents of the A. paniculata Nees…

DASUKI MS et al, Evaluation of Possible Toxic Effects on Male Reproductive Performance and Pregnancy Outcomes in Andrographis Paniculata Treated Rat, /306379191-Abstract: Andrographis paniculata has been extensively used in Malaya traditional medicine for promotion of well-being. However, the information of its potential toxic effects on male reproductive system are lacking. Therefore, the present study was aimed to investigate the possible effect of 50% ethanolic extract of AP on male reproductive performance and pregnancy outcome parameters. Fifty male rats received extract of A. panicula…

Tan ML et al, The effects of Andrographis paniculata (Burm.f.) Nees extract & diterpenoids on the CYP450 isoforms' activities, a review of possible herb-drug interaction risks. Drug Chem Toxicol. 2015;38(3):241-53-Abstract: Andrographis paniculata (Burm.f.) Nees is a popular medicinal plant and its components are used in various traditional product preparations. However, its herb-drug interactions risks remain unclear. This review specifically discusses the various published studies carried out to evaluate the effects of Andrographis paniculata (Burm.f.) Nees plant extracts & diterpenoids o…

WANG J et al, Determination of six components of Andrographis paniculata extract and one major metabolite of Andrographolide in rat plasma by liquid chromatography–tandem mass spectrometry, Jl of CHROMATOGRAPHY B, 951-2, 78-88, 2014- Abstract: A paniculata (AP) has been widely used in Asian countries to treat many kinds of diseases for several decades. Hutchison Medi pharma Ltd. developed an aqueous ethanol extract of A. paniculata (APE) named as HMPL-004 to treat inflammatory bowel diseases. The representative chemical components of HMPL-004 include Andrographolide (AND), neoandrographolid…

Thangavel MS et al, GC-MS analysis & larvicidal activity of Andrographis paniculata (Burm.f) Wall. Ex Nees against the dengue vector Aedes aegypti (L) (Diptera: Culicidae). Int. jl. Curr. Microbiol. App. Sci, 4(7): 392-403. 2015-

OKUNO K et al, Andrographis Reverses Gemcitabine Resistance through Regulation of ERBB3 & Calcium Signaling Pathway in Pancreatic Ductal Adenocarcinoma, Biomed, 11(1):119, 2023-Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, primarily due to intrinsic or acquired resistance to chemotherapy, such as Gemcitabine (Gem). Naturally occurring botanicals, including Andrographis (Andro), can help enhance the anti-tumorigenic therapeutic efficacy of conventional chemotherapy through time-tested safety & cost-effectiveness. Accordingly, we hypothesized that A…

Lin HH et al, Andrographolide downregulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells. Toxicol Appl Pharmacol 250: 336-45.2011-Abstract: Andrographolide (Andro), a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, is known to possess multiple pharmacological activities. In our previous study, Andro had been shown to inhibit non-small cell lung cancer (NSCLC) A549 cell migration and invasion via down-regulation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Here we demonstrated that Andro inhibited the …

YEN TL et al, Andrographolide stimulates p38 Mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats, Transl Res, 170:57-72. 2016-Abstract: Stroke pathogenesis involves complex oxidative stress-related pathways. The nuclear factor erythroid-2-related factor 2 (Nrf2) & heme oxygenase 1 (HO-1) pathways have been considered molecular targets in pharmacologic intervention for ischemic diseases. Andrographolide, a labdane diterpene, has received increasing…

SHARMA P et al, Andrographis-mediated chemo sensitization through activation of ferroptosis & suppression of β-catenin/Wnt-signaling pathways in colorectal cancer, CARCINIGENESIS, 41(10):1385-94, 2020-ABSTRACT: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in the USA. As much as 50-60% of CRC patients develop resistance to 5-fluorouracil (5FU)-based chemotherapeutic regimens, attributing the increased overall morbidity & mortality. In view of the growing evidence that active principles in various naturally occurring botanicals can facilitate chemo sen…

MALIK Z et al, Inhibition of hepatocellular carcinoma cell proliferation through regulation of the Cell Cycle, AGE-RAGE, & Leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, & oroxylin A derived from Andrographis Paniculata (Burm.f.) Nees, Jl of Ethnopharmacol, 329: 118001.Abstract: In 2020, liver cancer contributed to approximately 0.9 million new cases & 0.83 million deaths, making it the third leading cause of mortality worldwide. Andrographis paniculata (Burm.f.) Nees (APN), a traditional Chinese or ethnic medicine extensively utilized in Asia, ha…

Raj RK, Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part—II, Indian Jl Physiol Pharmacol.; 19(1):1975.-Abstract: Alcoholic extracts of the rhizomes of Alpinia galanga, Andrographis paniculata, and bark of Cinnamomum Zeylanicum, rind of Citrus decumanum, Desmodium triflorum, and seeds of Hydnocarpus wightiana, rhizomes of Kaempferia galanga, Lippia nodiflora, and tender leaves of Morinda citrifolia, rhizomes of Pollia serzogonian, Tephrosia purpurea and rhizomes of Zingiber zerumbet showed good in vitro anthelmintic activity against human Ascari…

Amroyan E et al. Inhibitory effect of Andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomed 1999; 6:27-31.

RAJESWARI M et al, INVITRO ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF ANDROGRAPHIS PANICULATA AGAINST UROPATHOGENS, World Jl of Pharm & Pharmaceut Sci, 7(2) !572-4, 2017-ABSTRACT: The Invitro study was undertaken to identify the antibacterial activity and phytochemical analysis of ethanolic extract of Andrographis paniculata against uropathogens. A total of 100 urine samples were collected from the suspected patients & were examined for the identification of bacteria by standard procedures. Of the 100 urine samples, 47 isolates were identified (gram positive & gram-negative bacteria) vi…

Thisoda P et al, Inhibitory effect of Andrographis paniculata extract & its active diterpenoids on platelet aggregation. Eur Jl of Pharmacol, 553, 39–45, 2006-Abstract: Andrographis paniculata has been widely used for the prevention & treatment of common cold especially in Asia & Scandinavia. The three active diterpenoids from this plant, including aqueous plant extracts, were investigated for the inhibitory effect on platelet aggregation in vitro. The results indicated that andrographolide (AP (1)) & 14-deoxy-11,12-didehydroandrographolide (AP (3)) significantly inhibited thrombin-induced …

Yang L et al, Andrographolide enhances 5-fluorouracil induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer Letters 276, 180–8, 2009.

Rahmi EP et al, Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels & Reducing Monosodium Urate Crystal-Induced Inflammation, Front Pharmacol, 12:787125, 2022-Abstract: Andrographis paniculata has been found to have anti-inflammatory & immunostimulatory effects. This study was to investigate antihyperuricemic & anti-inflammatory effects of A. paniculata leaf extracts. Andrographolide, 14-deoxy-11,12-didehydroandrographolide, & neoandrographolide were quantified in 80% ethanol (EtOH80) & water extracts using High Performance Liquid C…

Mishra US et al, Antibacterial Activity of Ethanol Extract of Andrographis paniculata, Indian J Pharm Sci. 2009; 71(4): 436–8.-Abstract: In the present study the ethanol extract of the aerial part of A paniculata was prepared and evaluated for antimicrobial activity against eleven bacterial strains by determining minimum inhibitory concentration and zone of inhibition. Minimum inhibitory concentration values were compared with control and zone of inhibition values were compared with standard ciprofloxacin in concentration 100 and 200 μg/ml. The results revealed that, the ethanol extract is …

ISLAM MT et al, Andrographolide, a diterpene lactone from Andrographis paniculata & its therapeutic promises in cancer, Cancer Letters, 420:129-45, 2018-Abstract: The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, & neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases…

Zhao HY et al, Antithrombotic effects of Andrographis paniculata Nees in preventing myocardial infarction. Chin Med Jl (Engl) 1991; 104:770-5-Abstract: n 16 dogs the endothelium of the left anterior descending coronary artery was injured mechanically. Then a copper wire was inserted into the lumen as a choke of flow & the vessel was slightly compressed from outside by a constrictor. Eight dogs had been treated beforehand with a preparation of flavone extracted from the root of the Chinese medicinal herb Andrographis paniculata (TFAP). In the control group, saline solution was given, the epi…

Geethangili M et al: Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in Jurkat cells, Phytother Res, 2008; 22(10): 1336-Abstract: Herbal medicines are now attracting attention as potential sources of anticancer agents. Andrographis paniculata is a traditionally used anticancer herb in Indian & Chinese herbal medicine. Phytochemical investigation of the ethanol extract of the aerial parts of this herb resulted in the isolation of 14 compounds including flavonoids and Labdane diterpenoids. This is the first isolation of compound 6 from a natural source, & the aeri…

JAYAKUMAR. T et al, Experimental & Clinical Pharmacology of Andrographis paniculata & Its Major Bioactive Phytoconstituent Andrographolide, Evid Based Comp & Alter Med, 846740, 2013-Abstract: Andrographis paniculata (Burm. F) Nees, generally known as "king of bitters," is an herbaceous plant in the family Acanthaceae. In China, India, Thailand, & Malaysia, this plant has been widely used for treating sore throat, flu, and upper respiratory tract infections. Andrographolide, a major bioactive chemical constituent of the plant, has shown anticancer potential in various investigations. Androgr…

ADEDAYO BC et al, Effect of Andrographis paniculata & Phyllanthus amarus leaf extracts on selected biochemical indices in Drosophila melanogaster model of neurotoxicity, Chem Toxicol, 45(1):407-16.2022-Abstract: Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity & neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extracts of Andrographis paniculata & Phyllanthus amarus leaves on Al-indu…

NADIG Shobha S et al, EFFECT OF HEPATOGARD - AN INDIGENOUS FORMULATIONON DEXAMETHASONE INDUCED ANTIHEALING EFFECTS IN MALE ALBINO RATS, Indian Jl Physiol Pharmacol 1999; 43 (2): 230-4-Abstract: Hepatogard ®, is a multi-ingredient phytopharmaceutical product ·containing crude powders of eleven plants. Its effect on the different parameters of wound healing was assessed alone and in the presence of dexamethasone. The parameters chosen for the study were the breaking strength of incised wound, breaking strength of granulation tissue and hydroxyproline content. The result showed that Hepatogard…

MA R et al, Antitumor effects of Andrographis via ferroptosis-associated genes in gastric cancer, Oncol Lett, 22(1):523, 2021-abstract: The overall prognosis of advanced/metastatic gastric cancer (GC) remains poor despite the development of pharmacotherapy. Therefore, other treatment options, such as complementary & alternative medicine, should be considered to overcome this aggressive malignancy. Andrographis, which is a generally unharmful botanical compound, has gained increasing interest for its anticancer effects in multiple malignancies via the regulation of cancer progression-associa…

SURIANI M.N. et al, Cytotoxicity Activity of Andrographis Paniculata Ethanolic Extract Against Vero Cell Line & Chicken Embryo Fibroblast Cells, 25th Vet Association Malaysia (2013)-Abstract: Ethanolic extract of Andrographis paniculata (APE) were evaluated for their in vitro cytotoxicity activity against Vero cell line & chicken embryo Fibroblast (CEF) primary cell. The in vitro cytotoxicity activity was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide (MTT) assay. The maximal nontoxic dose (MNTD) of ETOH APE against the CEF was observed at 20.48 μg/ml, while none w…

PERERA WPRT et al, Antiviral Potential of Selected Medicinal Herbs & Their Isolated Natural Products, Biomed Res Int, 7572406, 2021-Abstract: Viruses are responsible for a variety of human pathogenesis. Owing to the enhancement of the world population, global travel, & rapid urbanization, & infectious outbreaks, a critical threat has been generated to public health, as preventive vaccines & antiviral therapy are not available. Herbal medicines & refined natural products have resources for the development of novel antiviral drugs. These natural agents have shed light on preventive vaccine de…

Wiart C et al, Antiviral properties of ent-labdene diterpènes of Andrographis paniculata Nees, inhibitors of herpès simplex virus type 1. Phytother. Res. 2005, 19, 1069-1070.

Chen JX et al: Activity of Andrographolide & its derivatives against influenza virus in vivo & in vitro. Biol Pharm Bull 2009, 32(8):1385-91.

SWARGIARY G et al, Molecular docking & simulation studies of phytocompounds derived from Centella asiatica & Andrographis paniculata against hexokinase II as mitocans agents, Mitochondrion, 61 :138-46, 2021-Abstract: Hexokinase II (HK2), a glycolytic enzyme is commonly overexpressed in most cancer types. The overexpression of HK2 is reported to promote the survival of cancer cells by facilitating the constant ATP generation and protecting the cancer cell against apoptotic cell death. Hence, HK2 is considered as potential target of many mitochondria targeting anticancerous agents (referred t…

Pitinidhipat N et al, Antibacterial activity of Chrysanthemum indicum, Centella asiatica & Andrographis paniculata against Bacillus cereus & Listeria monocytogenes under osmotic stress. Assumption Univ Jl of Technol. 2012;15(4):239–24-Abstract: Bacillus cereus & Listeria monocytogenes have an ability to survive in high osmotic stress. Three Thai herbs; Chrysanthemum indicum, Centella asiatica & Andrographis paniculata, are chosen to study their antibacterial activity on B. cereus & LM 10403S under normal & osmotic stress (5% NaCl) condition by agar disc diffusion method. The in vitro antiba…

YANG EJ et al, Andrographolide, a major component of Andrographis paniculata leaves, has the neuroprotective effects on glutamate-induced HT22 cell death, Jl of Functional Foods, 9:162-72, 2014--bstract: Andrographis paniculata is a traditional herbal medicine that is used for the treatment of inflammation-related disorders, dyspepsia, & diarrhea. Recently, the biological effects of AP on cancer, microbial infections, cardiovascular disease, & inflammation were reported. However, neuroprotective actions of AP during glutamate-induced oxidative stress have not been investigated. In this stud…

JAIN J et al, Antiviral activity of ethanolic extract of Nilavembu Kudineer against dengue & chikungunya virus through in vitro evaluation, Jl of Ayurveda & Integrative Med, 2020•Abstract: Currently, no vaccines or modern drugs are available for dengue & chikungunya & only symptomatic relief is provided to the patients. Siddha medicine, a traditional form of indigenous medical system uses specific polyherbal formulations for the treatment of such infections with considerable success. One such polyherbal formulation for the treatment of chikungunya & dengue is Nilavembu kudineer (NVK). The m…

Khan I et al, Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway, Anticancer Agents Med Chem, 21(4):487-97, 2021-Abstract: Recently, the Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. However, the efficacy of previously known Notch inhibitors in colon cancer is still unclear. The purpose of this study was to investigate the effect of andrographolide on aberrantly activated Notch signaling in SW-480 cells in vitro. Methods: The cytostatic potential of andrographolide…

Li J et al, Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway & suppresses breast cancer growth. Oncol Targets Ther 2015; 8:427-35.

Subramanian R et al, In vitro glucosidase & a-amylase enzyme inhibitory effects of Andrographis paniculata extract & Andrographolide. Acta Biochimica Polonica 55, 391–8, 2008.

RAMAN S et al, Andrographis paniculata Dosage Forms & Advances in Nanoparticulate Delivery Systems: An Overview, Mol, 27(19):61-4.2022-Abstract: Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, & neoandrographolide. A World Health Organization (WHO) monograph on selected medicinal plants showed that AP extracts & its major diterpene lactones have promising anti-inflammatory, antidiabetic, antimalarial, anticancer, antifungal, antibacterial, antioxidant, & hypoglycemic activiti…

Ooi JP et al, Andrographolide & 14-deoxy-11, 12-didehydroandrographolide inhibit cytochrome P450s in HepG2 hepatoma cells. Life Sci. 2011; 88(9-10): 447–54.

Reyes BAS et al, Anti-diabetic potentials of Momordica charantia & Andrographis paniculata & their effects on estrous cyclicity of alloxan-induced diabetic rats, Jl of Ethnopharm, 105(1-2) :196-200, 2006-Abstract: Momordica charantia & Andrographis paniculata are the commonly used herbs by the diabetic patients in Pampanga, Philippines. While the anti-diabetic potential of MC is well established in streptozocin- or alloxan-induced diabetic animals, the anti-diabetic potential of AP in alloxan-induced diabetic rat is not known. Neither the effects of these herbs on estrous cyclicity of allox…

TARACHAND SP et al, In silico molecular docking study of Andrographis paniculata phytochemicals against TNF-α as a potent anti-rheumatoid drug, Jl of Biomol Struct Dyn, 41:7; 2023-Abstract: Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine which plays a crucial role in controlling inflammatory responses. The pathway of Rheumatoid arthritis (RA) leading to TNF-alpha is activated by macrophages and quite often by natural killer cells & lymphocytes. In the inflammatory phase, it is believed to be the main mediator & to be anchored with the progression of different diseases such as …

SURIYO T et al, Andrographis paniculata extracts & major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinome cells by inducing cell cycle arrest & apoptosis. Planta Med. 2014; 80(7):533-43.-Abstract: The present study reports that A. paniculata extracts potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. A. paniculata extracts with different contents of major diterpenoids, including andrographolide, 14-deoxy-11,12-didehydroandrographolide, neoandrographolide, & 14-deoxyandrographolide, exhibited a different potenc…

Sukma-Wati S et al, Uji Efek Hipoglikemik Kombinasi Ekstrak Etanol Daun Sambiloto (Andrographis Paniculata Nees) Dengan Acarbose Pada Tikus Putih (Rattus Norvegicus) Ter Induksi Aloksan. Jl Ilm As-Syifaa, 8(2):75-82, 2016-Abstract: Acarbose & sambiloto have the same mechanism of action in lowering blood glucose levels by inhibiting alphaglucosidase enzymes in the gut. This study aims to determine the hypoglycemic effect & combination effect from ethanol extract of AP leaves with acarbose in rat (Rattus norvegicus) induced alloxan. Twelve Wistar rats were divided into 4 groups; negative cont…

Poolsup N et al, Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: Systematic review of randomized controlled trials. Jl Clin Pharm Ther. 2004; 29(1): 37-45.

JULATON T et al, In Silico Insights on the Pro-Inflammatory Potential of Polycyclic Aromatic Hydrocarbons & the Prospective Anti-Inflammatory Capacity of Andrographis paniculata Phytocompounds, Environ Res Public Health, 19(14):8588. 2022-Abstract: Inflammation linked to various diseases is the biological response to certain stimuli. The pro-inflammatory potential of Polycyclic Aromatic Hydrocarbons (PAHs) as potential inducers of inflammation bound to the Toll-like Receptor 4 (TLR4) & the anti-inflammatory capacity of A. paniculata (AP) phytocompounds as prospective inhibitors of the Nucle…

Yu B.C et al, Antihyperglycemic effect of Andrographolide in streptozotocin-induced diabetic rats. Planta Medica 69, 1075–9, 2003.

Gupta S et al, Combinational effect of Asparagus racemosus, Andrographis paniculata & Dioscorea villosa for Anthelmintic & Antimicrobial potential. Inter Jl Pharmaceut Sci Review & Res, 2012; 16(2):104-7-Abstract: Asparagus racemosus, Andrographis paniculata & Dioscorea villosa are traditionally used as herbal medicine. In the present study, the aerial plant parts were subjected to hydroalcoholic extraction & the extracts were used to evaluate their antimicrobial & anthelmintic potential. The extracts of all the three plants at concentrations of 4, 8 & 16 mg/ml & their combination (concent…

YU Y et al, Discovery of ent-labdane derivatives from Andrographis paniculata & their anti-inflammatory activity, Phytochem, 219:113986. 2024-Abstract: The plant Andrographis paniculata has a long history of cultivation in Southeast Asia, especially its extensive anti-inflammatory activity, & the famous natural antibiotic andrographolide comes from this plant. In China, AP, as the main crop, has become a major source of traditional Chinese medicine (TCM) for the clinical treatment of inflammation. To further explore the diverse diterpene lactones with better anti-inflammatory activity from …

Zhang C et al, Cardiovascular activity of 14-deoxy-11,12- didehydro-andrographolide in the anaesthetised rat & isolated right atria. Pharmacol Res, 38, 413–7, 1998.

Brahmane RI et al, Partial in vitro & in vivo red scorpion venom neutralization activity of Andrographis paniculata. Pharmacogn Res 2011; 3:44-8.

THAI QK et al, Investigating Andrographis paniculata Compounds for Apoptosis Induction in Cancer, Pac J Cancer Prev, 26(7):2657-67.2025-Abstract: Reactivating the apoptosis pathway in cancer cells represents a crucial therapeutic strategy for cancer treatment, as malignant cells often evade apoptosis to sustain uncontrolled proliferation. Among the anti-apoptotic proteins, Bcl-xL has been implicated in the pathogenesis of various cancers due to its overexpression. Inhibition of this protein has therefore emerged as a key target for several FDA-approved anticancer drugs. In recent decades, r…

Dasuki MS et al, Effects of 50% Ethanolic Extract of Andrographis Paniculata on Sexual Behavior & Serum Hormonal Assay in Male Sprague Dawley Rats, Inter Jl of Appl Biol & Pharmaceut Technol, 6(1): 2015.-ABSTRACT: Andrographis paniculata has been used for centuries as a medicinal herb for the treatment of various ailments. The present study was aimed to investigate the possible effect of AP extract on male sexual behavior parameters & sex hormone levels. Fifty Sprague Dawley male rats received 50% ethanolic extract of AP by gavaging for 10 weeks at the doses of 0.5, 1, 10, 100, 1000 mg/kg, …

Pekthong D et al, Differential inhibition of rat & human hepatic cytochrome P450 by Andrographis paniculata extract & Andrographolide. Jl of Ethnopharm 2008; 115, 432–40.

Yu B.C et al, Mediation of -endorphin in andrographolide-induced plasma glucose-lowering action in type I diabetes-like animals. Naunyn Schmiedebergs Arch of Pharmacol, 377, 529–40, 2008.

Harjotaruno S et al, Apoptosis inducing effect of andrographolide on TF-47 human breast cancer cell line. Afr Jl Tradit Comp Alter Med 2008; 4:345-51.

GAO H et al, Andrographolide inhibits multiple myeloma cells by inhibiting the TLR4/NF-κB signaling pathway. Mol Med Rep. 13(2):1827-32, 2016.-Abstract: Andrographolide is an active component from the extract of Andrographis paniculata [(Burm.f) Nees], a medicinal plant from the Acanthaceae family. Pharmacological studies have revealed that Andrographolide possesses antibacterial, anti-inflammatory, antiviral, immune regulatory and hepatoprotective properties, & is efficacious in the treatment of cardiovascular diseases, while exhibiting low toxicity and low cost. The present study aimed to…

Rajagopal S et al, Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. Jl Exp Ther Oncol 2003; 3:147-58.

SHIMURA T et al, enhanced anti-cancer activity of Andrographis with oligomeric proanthocyanidins through activation of metabolic & ferroptosis pathways in colorectal cancer, Sci Rep, 11(1):7548, 2021-Abstract: The high degree of morbidity & mortality in colorectal cancer (CRC) patients is largely due to the development of chemoresistance against conventional chemotherapeutic drugs. In view of the accumulating evidence that various dietary botanicals offer a safe, inexpensive & multi-targeted treatment option, herein, we hypothesized that a combination of Andrographis paniculata & Oligomeric…

Zhang CY et al, Effects of 14-deoxyandrographolide & 14-deoxy-11,12-didehydro-andrographolide on nitric oxide production in cultured human endothelial cells. Phytother Res, 13, 157–9, 1999.

Ventaka BR et al, Utilizing Andrographis paniculata leaves & roots by effective usage of the bioactive andrographolide & its nano delivery: investigation of anti-kindling & antioxidant activities through in silico & in vivo studies, Front Nutr, 10:1185236, 2023-Abstract: To valorize the bioactive constituents abundant in leaves & other parts of medicinal plants with the objective to minimize the plant-based wastes, this study was undertaken. The main bioactive constituent of Andrographis paniculata, an Asian medicinal plant, is andrographolide (AG, a diterpenoid), which has shown promising …

Dutta A et al Filaricidal properties of a wild herb, Andrographis paniculata J Helminthol, 1982; 56:81–4.-Abstract: Alcohol and aqueous extracts of flowers of Azadirachta indica were tested in vitro for their potential Antifilarial activity against whole worm, nerve muscle (n.m.) preparation & microfilariae of Setaria cervi. The effects of alcohol and aqueous extracts were similar in nature on the spontaneous movements of whole worm & nerve muscle preparation. On the whole worm, the response was characterized by initial increase in tone, rate and amplitude of contractions followed by revers…

Puri A et al, Immunostimulant agents from Andrographis paniculata Jl of Nat Prod, 56, 995-9, 1993.

MA J et al, Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity & cognitive impairment through regulating the p62-keap1-Nrf2 pathway, BMC Comp Med Ther, 23:441, 2023--Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative & remains incurable. Aluminum is a potent neurotoxin associated with AD. The main pathological features of AD are extracellular amyloid-β protein deposition & intracellular hyperphosphorylated Tau protein. A body of evidence suggest that oxidative stress & autophagy are involved in the pathogenesis of AD. Andrographis pa…

Malik Z et al, Anticancer potential of andrographolide from Andrographis paniculata (B.) - Nees & its mechanisms of action, Jl Ethnopharmacol, 272:113936. 2021--Abstract: Synthetic drugs used for cancer treatment have side effects that may be immunosuppressive, can cause liver, kidney & cardiac toxicity, & infertility & ovarian failure, among others. Thus, herbal drugs could be used in the cancer treatment as an adjuvant therapy. Andrographis paniculata (Burm.f.) Nees (AP) is one of the traditional herbs used in different alternative medicinal systems such as Ayurveda, Unani, Chinese, Malay…

Yoopan N et al, Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide & Andrographis paniculata extracts. Planta Medica 73, 503–511, 2007.

Allan J et al. Reproductive & Fertility Effects of an Extract of Andrographis paniculata in Male Wistar Rats. Int Jl Toxicol: 28, 4, 308-17, 2009-Abstract: The possible effect of extract of Andrographis paniculata standardized to >or=10% andrographolide, the main bioactive component, on male fertility in albino Wistar rats was evaluated, by orally administering 0, 20, 200, & 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating. The treated groups showed no signs of dose-dependent toxicity. The body weight gain & feed consumption were not affected at any o…

Wasmann S et al, Antioxidant, Total Phenolic Content & Cytotoxicity Evaluation of Selected Malaysian Plants, Mol 2011, 16, 3433-43-Abstract: Aqueous & ethanol extracts of different traditional Malaysian plants (Polygonum Minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia & S crispus) were evaluated for their antioxidant properties, total phenolic content & cytotoxic activity. Antioxidant activity was evaluated by using 1,1-diphenyl-1-Picrylhydrazyl (DPPH) & ferric reducing antioxidant power (FRAP) assays. The results showed that ethanol extracts contain high antioxida…

ZHAO Y et al, Andrographis overcomes 5-fluorouracil-associated chemoresistance through inhibition of DKK1 in colorectal cancer, Carcinogenesis, 42(6):814-25, 2021-abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related deaths in the USA. 5-Fluorouracil (5FU)-based chemotherapeutic drug remains a mainstay of CRC treatment. Unfortunately, ~50-60% of patients eventually develop resistance to 5FU, leading to poor survival outcomes. Our previous work revealed that Andrographis enhanced 5FU-induced anti-cancer activity, but the underlying mechanistic understanding lar…

Jada SR et al, Benzylidene derivatives of andrographolide inhibit growth of breast & colon cancer cells in vitro by inducing G(1) arrest & apoptosis, Br Jl Pharmacol, 155(5):641-54, 2008-Abstract: Andrographolide, the major phytoconstituent of Andrographis paniculata, was previously shown by us to have activity against breast cancer. This led to synthesis of new andrographolide analogues to find compounds with better activity than the parent compound. Selected benzylidene derivatives were investigated for their mechanisms of action by studying their effects on the cell cycle progression & c…

Burgos RA et al. Testicular toxicity assessment of Andrographis paniculata dried extract in rats. Jl Ethnopharmacol. 1997; 58:219-24-Abstract: The possible testicular toxicity of Andrographis paniculata, Nees (Acanthaceae) standardized dried extract was evaluated in male Sprague Dawley rats for 60 days. No testicular toxicity was found with the treatment of 20, 200 and 1000 mg/kg during 60 days as evaluated by reproductive organ weight, testicular histology, ultrastructural analysis of Leydig cells and testosterone levels after 60 days of treatment. It is concluded that A paniculata dried e…

Arulmozhi T et al, in vitro anti leptospiral activity of ethanolic extract of the leaf of Andrographis paniculata Nees (Acanthaceae), Int. Jl. Curr. Res. Biol. Med. 2(2): 24-7, 2017 Leptopsirosis is a zoonotic infection with a worldwide distribution that is associated with both endemic & epidemic diseases with the incidence of disease being highest in tropical climates. The MIC of ethanolic extract of the leaf of Andrographis paniculata for a total of 5 leptospiral serovars were tested for their susceptibility to its antileptospiral activity. Among the tested serovars L. australis, L. icter…

AZIMAH D et al, IMMUNOMODULATOR EFFECT OF COMBINATION OF Andrographis paniculata (Burm. f.) Nees HERB & GINGER RHIZOME (Curcuma xanthorrhiza Roxb.) ETHANOLIC EXTRACT ON CELL PROLIFERATION OF Balb/c MICE LYMPHOCYTES IN VITRO, Trad Med, 21(3) :2016.-Abstract: Our susceptibility to various infectious diseases can be avoided by increasing the specific immune responses either by the proliferation of lymphocytes. Immunomodulator effect of Andrographis paniculata (Burm.f.) Nees) & Curcuma xanthorrhiza Roxb have been well evaluated. Empirically, the East Borneo’s tribe combined both herbs to treat …

Jindal S et al, ANDROGRAPHOLIDE LOADED TOPICAL NANOCARRIERS FOR MANAGEMENT OF PSORIASIS: A SAFE AND EFFECTIVE APPROACH, Plant Archives 21(Suppliment-1):1899-902, 2021-

Zhao F et al, Antitumor activities of andrographolide, a diterpene from Andrographis paniculata by inducing apoptosis & inhibiting VEGF level. Jl of Asian Nat Prod Res, 10, 467–73, 2008-ABSTRACT: Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most sensitive cell line among the cell lines screened) via the activation of caspase 3,…

ILMIAH KT et al, effectivity test antidiabetic a combination of ethanol extracts sambiloto herbs (Andrographis paniculata) & Sambung Nyawa leaves (Gynura procumbens) in alloxan-induced diabetes mellitus rat, Thesis Farmasi Surakarta, 2019--Abstract: Diabetes mellitus (DM) is a disease characterized by hyperglycemia caused by decreased insulin secretion or decreased insulin sensitivity or both. The prevalence of diabetes mellitus increases every year. The study was conducted to determine the combination of extracts ethanol herbs AP & GP leaves bitter a more effective decrease of blood glucos…

DESMUKH R et al, Andrographis paniculata & Andrographolide - A Snapshot on Recent Advances in Nano Drug Delivery Systems against Cancer, CURR Drug Deliv, 21(5) :631-44, 2024-Abstact: Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy & radiation therapies both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds, fevers, laryngitis, & infectious disorders have all been treated with Andrographis paniculata for centuries. Extracts of AP effectively treat various ailments, as well as cancer. The most active molecule in AP is androg…

CHURIYA et al, Antiviral & Immunostimulant activities of Andrographis Paniculata, HAYATI Jl of Biosci, 22(2) :67-72, 2015-Abstract: Andrographis paniculata is a medicinal plant which was reported to have anti-HIV, anti-pathogenic bacteria & Immuno-regulatory activities. The research purpose was to investigate the activity of Andrographis paniculata ethanol extract as antiviral & immunostimulant. A. paniculata leaves Oven-dried, then grinded & macerated with ethanol 90%, & the extract then analyzed using High Performance Liquid Chromatography (HPLC) to determine the content of active compoun…

KIZHAJEDATHIL MPJ et al, In-silico structural studies on anti-inflammatory activity of phytocompounds from the genus Andrographis, Jl Biomol Struct Dyn, 42(13):6543-55. 2024-Abstract: Plant species from the genus Andrographis were used in Ayurveda & in other folklore medicines for treating ailments for centuries. In this study, we have hypothesized to evaluate the secondary metabolites as potent anti-inflammatory agents from the genus Andrographis. A library of secondary metabolites of the said genus was curated from the PubChem database & was subjected to energy minimization using UCSF Chi…

Banerjee S et al, Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections - LC-MS/MS & network pharmacology analysis, Biochem Anal, 32(4):629-39. 2021-Abstract: Immunity boosting has emerged as a global strategy to fight the SARS-CoV-2 pandemic situation. In India, AYUSH systems of medicine have been promoted as an immune-protection strategy. Andrographis paniculata (Burm. F) Nees (AP) mentioned in Ayurveda has been widely used for treating sore throat, flu, & upper respiratory tract infections which may provide possible novel ther…