Citrullus colocynthis (Kolokent) : vertus médicinales en extraction alcoolique

Citrullus colocynthis (Kolokent, Coloquinte) — famille Cucurbitacée.

Synonymes scientifiques : Citrullus colocynthoides Pangalo, C pseudocolocynthisM.Roem., Colocynthis officinalis Schrad., Colocynthis vulgaris Schrad., Cucumis bipinnatifidus Wight ex Naudin, C colocynthoides Schult., Cucurbita colocyntha Link.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 8 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 131 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon SAQBAN LH (2022)

     Extrait Newly developed anticancer/antitumor medications appear to have been developed based on the extracted chemicals from CC due to the high contents of cucurbitacins. Several pharmacological investigations have been performed based on the medicinal application of Citrullus colocynthis.

   • Selon ZHENG MS (2020)

     Extrait colocynthis has shown to improve constipation, liver diseases, jaundice, typhoid fever, diabetes & asthma in traditional use. The main active ingredients of CC are cucurbitacin, flavonoids, alkaloids & phenolic acids, which have been proven to have antioxidant, anti-diabetic, anti-pathogenic microorganisms & anti-cancer activities in modern pharmacological research.

   • Selon Dehghani F (2006)

     Extrait One of these traditional medicines is Citrullus colocynthis, which is used by diabetic patients as an hypoglycemic agent, but it has been reported to cause gastrointestinal disorders after consumption in some patients. In the experimental groups a single daily dose of alcoholic extract of Citrullus colocynthis (50, 100, 200, 400 g/kg) was administered intraperitonally. (2019) — extrait : These results indicated that the oral administration of FAMEs for 60 days significantly reduced abdominal fat index, LDL cholesterol, triglycerides & hepatic lipids, a result that may support the use of FAMES as a hypolipidemic agent in obesity related disorders.

   • Selon Barth A (2002)

     Extrait A standardized extract of Citrullus colocynthis used as an oral natural laxative in folk medicine was tested for its influence on liver function parameters in vitro. Cytochrome P450 (CYP) dependent production of reactive oxygen species (ROS) under the influence of CC extract was investigated by means of stimulated lipid peroxidation (LPO), H2O2 formation & amplified chemiluminescence in rat liver microsomes.

2. 2

   Neuropathie diabétique

   Partie usitée : Fruit. Association synergique mentionnée : Curcuma longa-Rhizome, Myristica fragans-Noix & arille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon OSTOVAR M (s.d.)

     Extrait This study investigated the biochemical, histopathological & physiological effects of Citrullus colocynthis on peripheral neuropathy in rats with streptozotocin (STZ)-induced diabetes. Conclusion: The present study showed that CC fruit, through its antioxidant & hypoglycemic activities, has a positive effect in the treatment of diabetic neuropathy.

   • Selon KAUSA MA (2025)

     Extrait The present study investigates the therapeutic effects of an ethanolic polyherbal extract from Citrullus colocynthis (Bitter Apple), Curcuma longa (Turmeric), & Myristica fragrans (Nutmeg) using advanced in silico & analytical methods. Diabetic neuropathy is one of the severe complications of diabetes, which affects the quality of life in a patient & increases the risk of amputations & chronic wounds.

   • Selon Heyderi M (2016)

     Extrait The aim of the present study was to examine the safety & efficacy of a topical formulation of Citrullus colocynthis in patients with painful diabetic polyneuropathy (PDPN).

   • Selon GHAURI AO (2020)

     Extrait In vivo study used streptozotocin (STZ) induced diabetes model of rats. Citrus colocynthis has known anti-diabetic potential.

   • Selon SHI C (2014)

     Extrait Citrullus colocynthis is one of the most common traditional plants used as remedy against diabetes mellitus. Current studies have elaborated diabetes mellitus as one of the most prevalent endocrine disorders throughout the world.

3. 3

   Diabete mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon KAUSA MA (2025)

     Extrait The present study investigates the therapeutic effects of an ethanolic polyherbal extract from Citrullus colocynthis (Bitter Apple), Curcuma longa (Turmeric), & Myristica fragrans (Nutmeg) using advanced in silico & analytical methods. Diabetic neuropathy is one of the severe complications of diabetes, which affects the quality of life in a patient & increases the risk of amputations & chronic wounds.

   • Selon Aggarwal V (2012)

     Extrait Diabetes mellitus was induced by intraperitoneal (120 mg/kg b.w.) injection of alloxan monohydrate for three days & the animals showing blood glucose level in the range of 175-300 mg/dL were selected for study. colocynthis on the biochemical parameters of normal & alloxan-induced diabetic rats.

   • Selon GHAURI AO (2020)

     Extrait In vivo study used streptozotocin (STZ) induced diabetes model of rats. Citrus colocynthis has known anti-diabetic potential.

   • Selon SHI C (2014)

     Extrait Citrullus colocynthis is one of the most common traditional plants used as remedy against diabetes mellitus. Current studies have elaborated diabetes mellitus as one of the most prevalent endocrine disorders throughout the world.

   • Selon Cheng X (s.d.)

     Extrait Citrullus colocynthis (L.) Schrad. In this review, the scientific evidence for the biological activity of CC against insecticide, cytotoxic, antidiabetic effects are summarized,.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.